MIA_01100_1

Protein

Length

1,278 amino acids

Protein function

EGGNOG:	0PG7Q	RAD50	DNA repair protein Rad50
SGD closest match:	S000005194	RAD50	DNA repair protein RAD50
CGD closest match:	CAL0000184671	RAD50	MRX complex DNA-binding subunit

Protein alignments

	%id	Aln length	E-value
MCA_04503_1	47.816%	1282	0.0	MCA_04503_1
A0A0J9X3K7_GEOCN	40.584%	1301	0.0	Similar to Saccharomyces cerevisiae YNL250W RAD50 Subunit of MRX complex, with Mre11p and Xrs2p OS=Geotrichum candidum GN=BN980_GECA02s00626g PE=4 SV=1
UniRef50_A0A0J9X3K7	40.584%	1301	0.0	Similar to Saccharomyces cerevisiae YNL250W RAD50 Subunit of MRX complex, with Mre11p and Xrs2p n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X3K7_GEOCN
A0A060TDF0_BLAAD	39.130%	1288	0.0	ARAD1D47388p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D47388g PE=4 SV=1
Q6C910_YARLI	37.288%	1298	0.0	YALI0D15246p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D15246g PE=4 SV=1
A0A167C6E1_9ASCO	34.606%	1205	0.0	MRX complex DNA-binding subunit OS=Sugiyamaella lignohabitans GN=RAD50 PE=4 SV=1
A0A1D8PJD1_CANAL	33.689%	1312	0.0	MRX complex DNA-binding subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=RAD50 PE=4 SV=1
RAD50_YEAST	36.585%	697	2.52e-115	DNA repair protein RAD50 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RAD50 PE=1 SV=1
A0A1E3PR87_9ASCO	26.496%	351	8.67e-20	Uncharacterized protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81044 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0739

Protein family membership

DNA repair protein Rad50, eukaryotes (IPR004584)

Domains and repeats

Domain
106 - 193
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
1,165 - 1,246
P-loop containing nucleoside triphosphate hydrolase (IPR027417)

1 200 400 600 800 1000 1278

Detailed signature matches

IPR004584

DNA repair protein Rad50, eukaryotes
1. TIGR00606
  
  8 - 1,268
  
  TIGRFAMs
  TIGR00606 (TIGR00606)
IPR027417

P-loop containing nucleoside triphosphate hydrolase
1. SSF52540 (P-loop co...)
  
  106 - 193
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
  
  1,165 - 1,246
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)

no IPR

Unintegrated signatures

Coil

448 - 468

COILS
Coil (Coil)

677 - 704

COILS
Coil (Coil)

574 - 605

COILS
Coil (Coil)

410 - 430

COILS
Coil (Coil)

997 - 1,017

COILS
Coil (Coil)

1,041 - 1,071

COILS
Coil (Coil)

946 - 987

COILS
Coil (Coil)

733 - 753

COILS
Coil (Coil)

371 - 391

COILS
Coil (Coil)

471 - 498

COILS
Coil (Coil)

819 - 887

COILS
Coil (Coil)
G3DSA:1.20.11...

153 - 471

GENE3D
G3DSA:1.20.1170.10 (G3DSA:1.20.1170.10)
G3DSA:1.20.12...

475 - 635

GENE3D
G3DSA:1.20.120.330 (G3DSA:1.20.120.330)
G3DSA:1.20.5.110

938 - 999

GENE3D
G3DSA:1.20.5.110 (G3DSA:1.20.5.110)
G3DSA:3.40.50...

8 - 152

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)

1,027 - 1,273

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
PF13476 (AAA_23)

8 - 211

Pfam
PF13476 (AAA_23)
cd03240 (ABC_Rad50)

1,164 - 1,266

CDD
cd03240 (ABC_Rad50)

Residue annotation

ABC transporter si...

1,170C

ABC transporter signature motif
1,170C, 1,171S, 1,172A, 1,173G, 1,174Q, 1,175K, 1,176V, 1,177L, 1,178A, 1,179S
CDD
cd03240 (ABC_Rad50)

1,171S

ABC transporter signature motif
1,170C, 1,171S, 1,172A, 1,173G, 1,174Q, 1,175K, 1,176V, 1,177L, 1,178A, 1,179S
CDD
cd03240 (ABC_Rad50)

1,172A

ABC transporter signature motif
1,170C, 1,171S, 1,172A, 1,173G, 1,174Q, 1,175K, 1,176V, 1,177L, 1,178A, 1,179S
CDD
cd03240 (ABC_Rad50)

1,173G

ABC transporter signature motif
1,170C, 1,171S, 1,172A, 1,173G, 1,174Q, 1,175K, 1,176V, 1,177L, 1,178A, 1,179S
CDD
cd03240 (ABC_Rad50)

1,174Q

ABC transporter signature motif
1,170C, 1,171S, 1,172A, 1,173G, 1,174Q, 1,175K, 1,176V, 1,177L, 1,178A, 1,179S
CDD
cd03240 (ABC_Rad50)

1,175K

ABC transporter signature motif
1,170C, 1,171S, 1,172A, 1,173G, 1,174Q, 1,175K, 1,176V, 1,177L, 1,178A, 1,179S
CDD
cd03240 (ABC_Rad50)

1,176V

ABC transporter signature motif
1,170C, 1,171S, 1,172A, 1,173G, 1,174Q, 1,175K, 1,176V, 1,177L, 1,178A, 1,179S
CDD
cd03240 (ABC_Rad50)

1,177L

ABC transporter signature motif
1,170C, 1,171S, 1,172A, 1,173G, 1,174Q, 1,175K, 1,176V, 1,177L, 1,178A, 1,179S
CDD
cd03240 (ABC_Rad50)

1,178A

ABC transporter signature motif
1,170C, 1,171S, 1,172A, 1,173G, 1,174Q, 1,175K, 1,176V, 1,177L, 1,178A, 1,179S
CDD
cd03240 (ABC_Rad50)

1,179S

ABC transporter signature motif
1,170C, 1,171S, 1,172A, 1,173G, 1,174Q, 1,175K, 1,176V, 1,177L, 1,178A, 1,179S
CDD
cd03240 (ABC_Rad50)
Walker B cd03240

1,196L

Walker B
1,196L, 1,197I, 1,198A, 1,199L, 1,200D, 1,201E
CDD
cd03240 (ABC_Rad50)

1,197I

Walker B
1,196L, 1,197I, 1,198A, 1,199L, 1,200D, 1,201E
CDD
cd03240 (ABC_Rad50)

1,198A

Walker B
1,196L, 1,197I, 1,198A, 1,199L, 1,200D, 1,201E
CDD
cd03240 (ABC_Rad50)

1,199L

Walker B
1,196L, 1,197I, 1,198A, 1,199L, 1,200D, 1,201E
CDD
cd03240 (ABC_Rad50)

1,200D

Walker B
1,196L, 1,197I, 1,198A, 1,199L, 1,200D, 1,201E
CDD
cd03240 (ABC_Rad50)

1,201E

Walker B
1,196L, 1,197I, 1,198A, 1,199L, 1,200D, 1,201E
CDD
cd03240 (ABC_Rad50)
ATP binding site c...

1,200D

ATP binding site
1,200D, 1,201E, 1,238H
CDD
cd03240 (ABC_Rad50)

1,201E

ATP binding site
1,200D, 1,201E, 1,238H
CDD
cd03240 (ABC_Rad50)

1,238H

ATP binding site
1,200D, 1,201E, 1,238H
CDD
cd03240 (ABC_Rad50)
D-loop cd03240

1,204T

D-loop
1,204T, 1,205N, 1,206L, 1,207D
CDD
cd03240 (ABC_Rad50)

1,205N

D-loop
1,204T, 1,205N, 1,206L, 1,207D
CDD
cd03240 (ABC_Rad50)

1,206L

D-loop
1,204T, 1,205N, 1,206L, 1,207D
CDD
cd03240 (ABC_Rad50)

1,207D

D-loop
1,204T, 1,205N, 1,206L, 1,207D
CDD
cd03240 (ABC_Rad50)
H-loop/switch regi...

1,234I

H-loop/switch region
1,234I, 1,235V, 1,236I, 1,237T, 1,238H, 1,239D, 1,240E
CDD
cd03240 (ABC_Rad50)

1,235V

H-loop/switch region
1,234I, 1,235V, 1,236I, 1,237T, 1,238H, 1,239D, 1,240E
CDD
cd03240 (ABC_Rad50)

1,236I

H-loop/switch region
1,234I, 1,235V, 1,236I, 1,237T, 1,238H, 1,239D, 1,240E
CDD
cd03240 (ABC_Rad50)

1,237T

H-loop/switch region
1,234I, 1,235V, 1,236I, 1,237T, 1,238H, 1,239D, 1,240E
CDD
cd03240 (ABC_Rad50)

1,238H

H-loop/switch region
1,234I, 1,235V, 1,236I, 1,237T, 1,238H, 1,239D, 1,240E
CDD
cd03240 (ABC_Rad50)

1,239D

H-loop/switch region
1,234I, 1,235V, 1,236I, 1,237T, 1,238H, 1,239D, 1,240E
CDD
cd03240 (ABC_Rad50)

1,240E

H-loop/switch region
1,234I, 1,235V, 1,236I, 1,237T, 1,238H, 1,239D, 1,240E
CDD
cd03240 (ABC_Rad50)

Protein sequence

>MIA_01100_1
MVREKLYTIIECLKYVTTGDLPPNSKGGAFIHDPKLVGEREVLAQVKLAFTNVNGIQMIATRSMQLTVKKTTRTFKTLDG
QLLAIKDNKRVSVSTRGGDLDAQMPLYIGVSRAILENVIFCHQEDSLWPLSEPSVLKKKFDEIFESQKFTKALDNIKSLR
KEYAATIKIEQNSTDFYKQDKVRARAIEDRAIKISEDIDGLTTQVNKIKNDHDSILEEIKTVLDSSADLQDSLQELSKLR
SENNLYLKSIDRLKASTSTVFEGTDKDLKNQVLDFDKKLGSRAKRVQTVKAQIAKEKSTIEGINKHYRETNLKEGQLEAA
SKRYHGLLDDRTKKICATATIFELPEESLNKTTAFTHKEFSEIFGIMHNFSEKHKNQLDSEKAKNAVADNESSRRIQQVM
AKKLKLEHTAADFASEIRKCTEKIANLKRTVESTIVDEATVAYEKSQLTDLEKQLVKSTETLERIQAENGVQIKETRLAE
LSAVIEKLNSDLKLVNEESENRAKISYLQEDLAKREAALKALITAKKSDFATVNLDIEKLTTQQTESGLRDAISETQKIY
DETVHKYDTAKRELSLCESRLDMNKKNLEKLNKEKKELLESIYDQIDFDYKDYDEKVTELEIQERTVSSSIGENSFLKNL
NERAVEVAEKQDLCLMCCRKFHTSEEKDSFLSIMDKKNEHISDLEGLKNSLEQITEALKIVRDLSPSISRLKALENGLIP
YDLNEQPALECSVKEARSKVDSAKSAVDAAKTKLEHVESLRRASSDLVRNGAELTIIRGEIETVQAQLRIDTGDLGSSSQ
ILGQIGIKNEESKRVDKELRALLEERDQARILANKMESAINKKKQRIYDLQKQLDERNVAEAEIKTLDEERVKLNNLAAE
NKREIEAVALQVREEESLAADIKRKGAQREQEISAKYARMHDVLRDLETMCIEIDEYEKNGGDESLKKCRALVETLQEQL
KDTNAELDAQNKELTKAEMELADLSTHDRMLKDNLEIRRLQRRVDKNITRIQELENMNIEGQSEKLKQREIILNEEKTKL
FADAEGKMGEIKQLHEQLEAAQMELETTYKDIGEKYRRSLIKLHTLSVASDDLAKYAKALDSAIMKYHSMKMEEINRIID
ELWKKTYSGTDVDTILIRSENESARGNNRVYNYRVCMIKQDVELDMRGRCSAGQKVLASIIIRLALAECFGVNCGLIALD
EPTTNLDQDNIESLAKALGSIIATRRAQKNFQLIVITHDEKFLLHMNASAYTDHFYRVSRNDRQRSTIDWVPITRISE

GO term prediction

Biological Process

GO:0000723 telomere maintenance
GO:0006281 DNA repair

Molecular Function

GO:0016887 ATPase activity

Cellular Component

GO:0005634 nucleus
GO:0030870 Mre11 complex

Filter view on

Entry type

Status

Per-residue features