MIA_01092_1

Protein

Length

480 amino acids

Protein function

EGGNOG:	0QDB6	PGUG_04452	Monocarboxylate transporter
SGD closest match:	S000005479	MCH4	Probable transporter MCH4
CGD closest match:	CAL0000177667	orf19.6263	Uncharacterized protein

Protein alignments

	%id	Aln length	E-value
MCA_00480_1	53.448%	406	1.99e-129	MCA_00480_1
A0A0J9X330_GEOCN	49.257%	404	5.41e-129	Similar to Saccharomyces cerevisiae YOL119C MCH4 Protein with similarity to mammalian monocarboxylate permeases OS=Geotrichum candidum GN=BN980_GECA01s08436g PE=4 SV=1
UniRef50_A0A0J9YHP1	51.244%	402	1.43e-121	Similar to Saccharomyces cerevisiae YOL119C MCH4 Protein with similarity to mammalian monocarboxylate permeases n=3 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9YHP1_GEOCN
W0TYN6_YARLI	39.427%	454	1.17e-91	YALI0B04004p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B04004g PE=4 SV=1
MCH4_YEAST	39.268%	410	1.43e-86	Probable transporter MCH4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MCH4 PE=1 SV=1
Q5AAP8_CANAL	36.609%	407	5.75e-83	Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.6263 PE=4 SV=1
A0A167D661_9ASCO	41.439%	403	1.39e-81	Mch4p OS=Sugiyamaella lignohabitans GN=MCH4 PE=4 SV=1
A0A060TFU5_BLAAD	33.983%	462	2.76e-73	ARAD1D17292p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D17292g PE=4 SV=1
A0A1E3PDP2_9ASCO	31.264%	435	5.62e-50	MFS general substrate transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84190 PE=4 SV=1
A0A1E4TLK5_9ASCO	28.497%	386	1.39e-24	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1237 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0591

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
63 - 472
Major facilitator superfamily domain (IPR020846)

1 50 100 150 200 250 300 350 400 450 480

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  84 - 433
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. PS50850 (MFS)
  
  78 - 472
  
  PROSITE profiles
  PS50850 (MFS)
2. SSF103473 (MFS gene...)
  
  63 - 469
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
3. cd06174 (MFS)
  
  82 - 467
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

100 - 119

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

347 - 357

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

410 - 420

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

170 - 175

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

468 - 480

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

227 - 237

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

77 - 272

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

273 - 469

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

258 - 325

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

202 - 206

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

143 - 147

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

442 - 446

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

378 - 382

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1 - 76

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

120 - 142

TMHMM
TMhelix (TMhelix)

147 - 169

TMHMM
TMhelix (TMhelix)

451 - 473

TMHMM
TMhelix (TMhelix)

77 - 99

TMHMM
TMhelix (TMhelix)

419 - 441

TMHMM
TMhelix (TMhelix)

384 - 406

TMHMM
TMhelix (TMhelix)

327 - 349

TMHMM
TMhelix (TMhelix)

206 - 225

TMHMM
TMhelix (TMhelix)

238 - 257

TMHMM
TMhelix (TMhelix)

174 - 196

TMHMM
TMhelix (TMhelix)

356 - 378

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

447 - 467

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

207 - 226

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

77 - 99

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

326 - 346

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

120 - 142

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

358 - 377

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

238 - 257

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

176 - 201

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

421 - 441

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

383 - 409

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

148 - 169

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

Residue annotation

putative substrate...

96L

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

99S

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

100M

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

101G

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

103V

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

107V

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

124F

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

127F

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

128L

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

131I

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

135A

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

136S

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

138V

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

139G

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

186G

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

187A

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

190V

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

191T

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

194V

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

195S

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

198G

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

209M

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

210A

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

213T

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

214V

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

220G

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

304K

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

307I

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

308T

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

311Q

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

312T

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

315T

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

328S

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

332L

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

336N

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

339G

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

343R

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

392G

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

395N

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

396V

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

399V

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

403P

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

404A

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

407G

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

418R

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

419Y

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

422M

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

423Y

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

426A

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

427S

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

430V

putative substrate translocation pore
96L, 99S, 100M, 101G, 103V, 107V, 124F, 127F, 128L, 131I, 135A, 136S, 138V, 139G, 186G, 187A, 190V, 191T, 194V, 195S, 198G, 209M, 210A, 213T, 214V, 220G, 304K, 307I, 308T, 311Q, 312T, 315T, 328S, 332L, 336N, 339G, 343R, 392G, 395N, 396V, 399V, 403P, 404A, 407G, 418R, 419Y, 422M, 423Y, 426A, 427S, 430V
CDD
cd06174 (MFS)

Protein sequence

>MIA_01092_1
MSPELLEISLEPLTLLSPVITKLDFSTSNLHNDTPETATASGISLREPPLEISESAPETYDEDLNEEDEEDYPEGGVVAW
SVVLASFLGLFAVFGLCTSMGAVQAHVALHQLSNKSESQVSWIFSAFLFFIFLLASYVGPIYDAYGPYQLLIAGTFLFTL
GLITTSFCVEYYQFFLAFSVCAGIGGALLVTPIVSIIGQWFNKRRATAMALATVGGSVGGIVYPLMLRKLYSSIGYPWAL
RVLGFLCFGLLIFSLLITKTRMTPAKDSQSIRKTITRAATNMFDYRQLHDLRFTGLAIANFLGKIGITNCQTFLTSYALA
QNHTEGFSYAILAILNAAGIAGRIITGYLADKLGRFNTVIATCALSAFTVFVVWLPFGSTTAGLISFAVTHGFSNVGIVA
LAPACCGQICRTRNYGKRYGFMYFVASITVLVGVPISGALIRNGNDYTNFIIFDGVVYIATTLALLYSRYIAVGFRWCKW

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features