MCA_00480_1

Protein

Length

522 amino acids

RNA-seq: read pairs 4928, FPKM 116.4, percentile rank 81.3% (100% = highest expression)

Protein function

EGGNOG:	0QDB6	PGUG_04452	Monocarboxylate transporter
SGD closest match:	S000005833	MCH5	Riboflavin transporter MCH5
CGD closest match:	CAL0000177667	orf19.6263	Uncharacterized protein

Protein alignments

	%id	Aln length	E-value
MIA_01396_1	71.50%	400	0.0	MIA_01396_1
A0A0J9X330_GEOCN	60.80%	398	5e-171	Similar to Saccharomyces cerevisiae YOL119C MCH4 Protein with similarity to mammalian monocarboxylate permeases OS=Geotrichum candidum GN=BN980_GECA01s08436g PE=4 SV=1
UniRef50_A0A0J9YHP1	53.65%	397	8e-146	Similar to Saccharomyces cerevisiae YOL119C MCH4 Protein with similarity to mammalian monocarboxylate permeases n=3 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9YHP1_GEOCN
W0TYN6_YARLI	46.40%	403	2e-124	YALI0B04004p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B04004g PE=4 SV=1
A0A167D661_9ASCO	36.82%	497	4e-99	Mch4p OS=Sugiyamaella lignohabitans GN=MCH4 PE=4 SV=1
Q5AAP8_CANAL	39.73%	438	7e-98	Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.6263 PE=4 SV=1
MCH5_YEAST	35.38%	506	1e-93	Riboflavin transporter MCH5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MCH5 PE=1 SV=2
A0A060TFU5_BLAAD	38.31%	402	2e-90	ARAD1D17292p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D17292g PE=4 SV=1
A0A1E3PDP2_9ASCO	30.61%	441	8e-60	MFS general substrate transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84190 PE=4 SV=1
A0A1E4TLK5_9ASCO	32.22%	388	3e-40	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1237 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0405

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
109 - 514
Major facilitator superfamily domain (IPR020846)

1 50 100 150 200 250 300 350 400 450 522

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  142 - 420
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. PS50850 (MFS)
  
  127 - 514
  
  PROSITE profiles
  PS50850 (MFS)
2. SSF103473 (MFS gene...)
  
  109 - 511
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
3. cd06174 (MFS)
  
  131 - 509
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

185 - 195

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 130

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

246 - 256

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

454 - 464

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

510 - 522

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

391 - 401

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

308 - 338

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

329 - 512

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

126 - 319

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

422 - 426

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

218 - 222

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

276 - 286

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

156 - 166

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

365 - 369

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

485 - 489

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

428 - 450

TMHMM
TMhelix (TMhelix)

489 - 511

TMHMM
TMhelix (TMhelix)

286 - 306

TMHMM
TMhelix (TMhelix)

462 - 484

TMHMM
TMhelix (TMhelix)

400 - 418

TMHMM
TMhelix (TMhelix)

339 - 361

TMHMM
TMhelix (TMhelix)

371 - 393

TMHMM
TMhelix (TMhelix)

254 - 276

TMHMM
TMhelix (TMhelix)

198 - 220

TMHMM
TMhelix (TMhelix)

132 - 154

TMHMM
TMhelix (TMhelix)

169 - 191

TMHMM
TMhelix (TMhelix)

225 - 247

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

370 - 390

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

131 - 155

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

196 - 217

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

287 - 307

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

490 - 509

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

402 - 421

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

465 - 484

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

339 - 364

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

427 - 453

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

223 - 245

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

167 - 184

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

257 - 275

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
mobidb-lite (disord...)

18 - 51

MobiDB Lite
mobidb-lite (disorder_prediction)

79 - 119

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative substrate...

145I

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

148S

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

149M

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

150G

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

152I

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

153Q

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

173F

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

176F

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

177V

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

180C

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

184S

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

185G

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

187V

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

188G

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

235C

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

236A

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

239M

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

240T

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

243V

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

244A

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

247G

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

258I

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

259G

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

262T

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

263V

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

269G

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

348E

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

351V

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

352V

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

355V

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

356T

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

359T

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

372A

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

376L

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

380N

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

383G

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

387R

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

435G

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

438N

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

439G

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

442L

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

446P

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

447S

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

450G

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

461R

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

462Y

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

465L

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

466Y

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

469T

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

470S

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

473I

putative substrate translocation pore
145I, 148S, 149M, 150G, 152I, 153Q, 173F, 176F, 177V, 180C, 184S, 185G, 187V, 188G, 235C, 236A, 239M, 240T, 243V, 244A, 247G, 258I, 259G, 262T, 263V, 269G, 348E, 351V, 352V, 355V, 356T, 359T, 372A, 376L, 380N, 383G, 387R, 435G, 438N, 439G, 442L, 446P, 447S, 450G, 461R, 462Y, 465L, 466Y, 469T, 470S, 473I
CDD
cd06174 (MFS)

Protein sequence

>MCA_00480_1
MSATVTYQDMLEEHIEQPVKFTTPLNNSQETASKSAFQEYSQETDSGPVFRGVENIPMKNIPSFPSKVYGGENVNVTATG
LENNRTGNNYRAGHDPEFGDENDSFGNEQSTSEEEYEDIEYPEGGAEAWKVVLGSFLGMLCVLGIINSMGAIQAYISVNQ
LAQKSDLEISLIFSIFVFFCYIFSGQVGPFFDSFGPYHLSIIGAFFFTLGIMMTSLSTAYYQFFLSFSTCCGLGCALLMT
PQVAILGHWFNVKRGTAIGSATVGGSLGGVVFPIMLRKLYTSVGYAWAIRILGFICLGCLAASAYLMKPRLKKTQRPKFK
LVWSNVLDINSLKDMRFSWLIVANFLGELAVVNGVTYLTSYAIAQGVDETTAYLLLTILNSTGMVGRWLSGYLADKWGRF
NVLIVTIIMAFITIFVIWLPFKSVPSMITFAVLHGLCNGGILAGTPSCVGQICRTQDYGKRYGTLYFFTSFAILGGLPIS
AALIRGNDYSGLIIFTGALYVATMFALLFSRYCAVGFRLCKW

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features