Protein

MIA_01055_1

Length
364 amino acids

Browser: contig01:3024604-3025818-

Protein function

EGGNOG:0PFFEHST2SIR2 family histone deacetylase
SGD closest match:S000005936HST2NAD-dependent protein deacetylase HST2
CGD closest match:CAL0000178194HST2NAD-dependent protein deacetylase HST2

Protein alignments

%idAln lengthE-value
MCA_04594_157.78%3602e-129MCA_04594_1
A0A167F0M7_9ASCO55.75%3395e-112Histone deacetylase HST2 OS=Sugiyamaella lignohabitans GN=HST2 PE=4 SV=1
UniRef50_A0A167F0M755.75%3391e-108Histone deacetylase HST2 n=3 Tax=Dikarya TaxID=451864 RepID=A0A167F0M7_9ASCO
A0A060T3A6_BLAAD53.99%3269e-110ARAD1C35750p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C35750g PE=4 SV=1
A0A1E4TDX1_9ASCO49.67%3066e-89Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31058 PE=4 SV=1
HST2_CANAL49.09%3281e-88NAD-dependent protein deacetylase HST2 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HST2 PE=3 SV=2
A0A1E3PL15_9ASCO43.98%3572e-86SIR2-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46655 PE=4 SV=1
HST2_YEAST47.19%3033e-79NAD-dependent protein deacetylase HST2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HST2 PE=1 SV=1
A0A0J9XAX3_GEOCN48.42%2854e-78Similar to Saccharomyces cerevisiae YPL015C HST2 Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases OS=Geotrichum candidum GN=BN980_GECA06s02771g PE=4 SV=1
Q6C219_YARLI36.88%3014e-44YALI0F11583p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F11583g PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0415

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 364

Detailed signature matches

  1. Family IPR003000
    Sirtuin family
    1. PF02146 (SIR2)
  2. Family IPR017328
    Sirtuin, class I
    1. PIRSF037938 (SIR2_euk)
  3. Domain IPR029035
    DHS-like NAD/FAD-binding domain
    1. SSF52467 (DHS-like ...)
    2. G3DSA:3.40.50...
  4. Domain IPR026590
    Sirtuin family, catalytic core domain
    1. PS50305 (SIRTUIN)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. cd01408 (SIRT1)
  3. mobidb-lite (disord...)

Residue annotation

  1. NAD+ binding site ...
  2. substrate binding ...
  3. Zn binding site cd...

Protein sequence

>MIA_01055_1
MSSDLQNLATKLKDGKFSNVVFMVGAGISTSAGIPDFRTPGTGLYSNLARLKLPYPEAVFDISYFKRRPEAFYTLADELY
PTKFKPTRFHAFIKLLEDKGYLGKVFTQNIDTLERLAGVSDEKVIEAHGSFAKNHCIDCGHEMSTDELKRQMYKLDNDVI
LTSPPKIQKGETVGIPKCQSPSCSVSGGGLVKPDIVFFGEGLPEEFFEAWENDLPKADLVIVAGTSLAVSPFSSLPDEVE
HKVPRLLFNMEEVGTLGSRENDVLSLGSCDDMVKEFCNMCGWDTELDDLITSIHKELDSKYSETSEDNANLEKNEETAEA
LSKEISEKVENILAPEEEKAEKEKSEEDDDKSEIESLTKKIENL

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0008270 zinc ion binding
GO:0017136 NAD-dependent histone deacetylase activity
GO:0070403 NAD+ binding

Cellular Component

None predicted.