Protein

MCA_04594_1

Length
376 amino acids

Gene name: HST2

Description: NAD-dependent protein deacetylase HST2; member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases

Browser: contigC:3464138-3465344+

RNA-seq: read pairs 1130, FPKM 37.0, percentile rank 58.6% (100% = highest expression)

Protein function

Annotation:HST2NAD-dependent protein deacetylase HST2; member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases
KEGG:K11121SIR2 NAD-dependent histone deacetylase SIR2 [EC:3.5.1.-]
EGGNOG:0PFFEHST2SIR2 family histone deacetylase
SGD closest match:S000005936HST2NAD-dependent protein deacetylase HST2
CGD closest match:CAL0000178194HST2NAD-dependent protein deacetylase HST2

Protein alignments

%idAln lengthE-value
MIA_01055_162.78%3171e-128MIA_01055_1
A0A167F0M7_9ASCO61.46%2883e-114Histone deacetylase HST2 OS=Sugiyamaella lignohabitans GN=HST2 PE=4 SV=1
UniRef50_A0A167F0M761.46%2889e-111Histone deacetylase HST2 n=3 Tax=Dikarya TaxID=451864 RepID=A0A167F0M7_9ASCO
A0A060T3A6_BLAAD57.00%3075e-110ARAD1C35750p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C35750g PE=4 SV=1
A0A1E4TDX1_9ASCO49.31%2902e-82Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31058 PE=4 SV=1
A0A1E3PL15_9ASCO43.90%3282e-80SIR2-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46655 PE=4 SV=1
HST2_CANAL48.17%3016e-79NAD-dependent protein deacetylase HST2 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HST2 PE=3 SV=2
A0A0J9XAX3_GEOCN44.11%2974e-75Similar to Saccharomyces cerevisiae YPL015C HST2 Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases OS=Geotrichum candidum GN=BN980_GECA06s02771g PE=4 SV=1
HST2_YEAST44.74%3044e-70NAD-dependent protein deacetylase HST2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HST2 PE=1 SV=1
Q6C219_YARLI34.30%2771e-34YALI0F11583p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F11583g PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2440

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 376

Detailed signature matches

  1. Family IPR003000
    Sirtuin family
    1. PF02146 (SIR2)
  2. Family IPR017328
    Sirtuin, class I
    1. PIRSF037938 (SIR2_euk)
  3. Domain IPR029035
    DHS-like NAD/FAD-binding domain
    1. SSF52467 (DHS-like ...)
    2. G3DSA:3.40.50...
  4. Domain IPR026590
    Sirtuin family, catalytic core domain
    1. PS50305 (SIRTUIN)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. mobidb-lite (disord...)

Protein sequence

>MCA_04594_1
MPELKDIAERLAKGEFRNVVFMVGAGISTSAGIPDFRSPGTGLYSNLARFDLPYPEAVFEISYFRRNPHAFYTLAEELDP
AKYKPTMFHIFMKLVESKGYLRKVFTQNIDTLERRAGISESKVIEAHGSFAKNHCIDCRKEMHAEELKRQMYKLDKKKSN
EEDDETPSIGSTPLTLKNGQKVGIPKCECGGLVKPDIVFFGEGLPEEFFEGYSEDVPEADLVIVAGTSLTVSPFSMLPSE
APTSAVRVLFNLEQVGDFGTRSNDVLELDDCDSGIVRFAEMCGWGKDLDKLVKKIHKSLESFEKSQVENDTNGTEHDKEK
KKESKPAKEDFKPEESLSAKTSQKIAEKIGELVGPSDKKQEEEEDIKDLTDALDKL

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0008270 zinc ion binding
GO:0017136 NAD-dependent histone deacetylase activity
GO:0070403 NAD+ binding

Cellular Component

None predicted.