MIA_01052_1

Protein

Length

1,181 amino acids

Protein function

EGGNOG:	0PG9C	PGUG_02677	P-type ATPase
SGD closest match:	S000002678	CCC2	Copper-transporting ATPase
CGD closest match:	CAL0000193278	CCC2	Cu(2+)-transporting P-type ATPase

Protein alignments

	%id	Aln length
MCA_04589_1	58.547%	1129	MCA_04589_1
A0A0J9XKD6_GEOCN	54.896%	1062	Similar to Saccharomyces cerevisiae YDR270W CCC2 Cu(+2)-transporting P-type ATPase OS=Geotrichum candidum GN=BN980_GECA22s01341g PE=3 SV=1
UniRef50_A0A0J9XKD6	54.896%	1062	Similar to Saccharomyces cerevisiae YDR270W CCC2 Cu(+2)-transporting P-type ATPase n=2 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XKD6_GEOCN
A0A060T7N4_BLAAD	51.823%	905	ARAD1D04444p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D04444g PE=3 SV=1
A0A167FGR1_9ASCO	47.803%	956	Cu(2+)-transporting P-type ATPase CCC2 OS=Sugiyamaella lignohabitans GN=CCC2 PE=3 SV=1
Q6C7L8_YARLI	47.414%	928	YALI0D27038p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D27038g PE=3 SV=1
A0A1E3PIR6_9ASCO	44.229%	979	Heavy metal translocatin OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83177 PE=3 SV=1
Q5AG51_CANAL	39.548%	1105	Cu(2+)-transporting P-type ATPase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CCC2 PE=3 SV=1
ATU2_YEAST	38.845%	1004	Copper-transporting ATPase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CCC2 PE=1 SV=1
A0A1E4TC65_9ASCO	38.689%	915	Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_19929 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1077

Protein family membership

P-type ATPase (IPR001757)
- P-type ATPase, subfamily IB (IPR027256)

Domains and repeats

Domain
33 - 107
Heavy metal-associated domain, HMA (IPR006121)
Heavy metal-associated domain, copper ion-binding (IPR006122)
134 - 202
Heavy metal-associated domain, HMA (IPR006121)
Heavy metal-associated domain, copper ion-binding (IPR006122)
212 - 285
Heavy metal-associated domain, HMA (IPR006121)
Heavy metal-associated domain, copper ion-binding (IPR006122)
297 - 368
Heavy metal-associated domain, HMA (IPR006121)
479 - 537
P-type ATPase, transmembrane domain (IPR023298)
566 - 652
P-type ATPase, A domain (IPR008250)
653 - 759
P-type ATPase, transmembrane domain (IPR023298)
764 - 784
HAD-like domain (IPR023214)
786 - 1,104
HAD-like domain (IPR023214)
P-type ATPase, cytoplasmic domain N (IPR023299)

1 200 400 600 800 1000 1181

Detailed signature matches

IPR001757

P-type ATPase
1. TIGR01494
  
  889 - 1,081
  
  TIGRFAMs
  TIGR01494 (TIGR01494)
  
  546 - 789
  
  TIGRFAMs
  TIGR01494 (TIGR01494)
IPR027256

P-type ATPase, subfamily IB
1. TIGR01525
  
  465 - 1,107
  
  TIGRFAMs
  TIGR01525 (TIGR01525)
IPR006121

Heavy metal-associated domain, HMA
1. PS50846 (HMA_2)
  
  134 - 200
  
  PROSITE profiles
  PS50846 (HMA_2)
  
  300 - 366
  
  PROSITE profiles
  PS50846 (HMA_2)
  
  38 - 104
  
  PROSITE profiles
  PS50846 (HMA_2)
  
  215 - 281
  
  PROSITE profiles
  PS50846 (HMA_2)
2. PF00403 (HMA)
  
  136 - 197
  
  Pfam
  PF00403 (HMA)
  
  218 - 278
  
  Pfam
  PF00403 (HMA)
  
  303 - 363
  
  Pfam
  PF00403 (HMA)
  
  41 - 101
  
  Pfam
  PF00403 (HMA)
3. cd00371 (HMA)
  
  136 - 199
  
  CDD
  cd00371 (HMA)
  
  303 - 364
  
  CDD
  cd00371 (HMA)
  
  41 - 102
  
  CDD
  cd00371 (HMA)
  
  218 - 280
  
  CDD
  cd00371 (HMA)
4. SSF55008 (HMA, heav...)
  
  136 - 202
  
  SUPERFAMILY
  SSF55008 (HMA, heavy metal-associated domain)
  
  33 - 107
  
  SUPERFAMILY
  SSF55008 (HMA, heavy metal-associated domain)
  
  212 - 285
  
  SUPERFAMILY
  SSF55008 (HMA, heavy metal-associated domain)
  
  297 - 368
  
  SUPERFAMILY
  SSF55008 (HMA, heavy metal-associated domain)
IPR006122

Heavy metal-associated domain, copper ion-binding
1. TIGR00003
  
  136 - 198
  
  TIGRFAMs
  TIGR00003 (TIGR00003)
  
  218 - 279
  
  TIGRFAMs
  TIGR00003 (TIGR00003)
  
  41 - 102
  
  TIGRFAMs
  TIGR00003 (TIGR00003)
IPR023298

P-type ATPase, transmembrane domain
1. SSF81665 (Calcium A...)
  
  479 - 537
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
  
  653 - 759
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
IPR008250

P-type ATPase, A domain
1. SSF81653 (Calcium A...)
  
  566 - 652
  
  SUPERFAMILY
  SSF81653 (Calcium ATPase, transduction domain A)
IPR023214

HAD-like domain
1. SSF56784 (HAD-like)
  
  764 - 784
  
  SUPERFAMILY
  SSF56784 (HAD-like)
  
  861 - 1,104
  
  SUPERFAMILY
  SSF56784 (HAD-like)
2. G3DSA:3.40.50...
  
  904 - 1,071
  
  GENE3D
  G3DSA:3.40.50.1000 (G3DSA:3.40.50.1000)
IPR023299

P-type ATPase, cytoplasmic domain N
1. G3DSA:3.40.11...
  
  786 - 903
  
  GENE3D
  G3DSA:3.40.1110.10 (G3DSA:3.40.1110.10)
IPR017969

Heavy-metal-associated, conserved site
1. PS01047 (HMA_1)
  
  139 - 168
  
  PROSITE patterns
  PS01047 (HMA_1)
  
  220 - 249
  
  PROSITE patterns
  PS01047 (HMA_1)
  
  43 - 72
  
  PROSITE patterns
  PS01047 (HMA_1)
IPR018303

P-type ATPase, phosphorylation site
1. PS00154 (ATPASE_E1_E2)
  
  768 - 774
  
  PROSITE patterns
  PS00154 (ATPASE_E1_E2)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

757 - 1,058

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1,108 - 1,181

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

447 - 466

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

692 - 710

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 391

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.11...

429 - 785

GENE3D
G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)
G3DSA:3.30.70...

35 - 105

GENE3D
G3DSA:3.30.70.100 (G3DSA:3.30.70.100)

299 - 373

GENE3D
G3DSA:3.30.70.100 (G3DSA:3.30.70.100)

212 - 288

GENE3D
G3DSA:3.30.70.100 (G3DSA:3.30.70.100)

135 - 203

GENE3D
G3DSA:3.30.70.100 (G3DSA:3.30.70.100)
NON_CYTOPLASM... (N...)

417 - 427

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

1,083 - 1,087

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

731 - 735

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

490 - 671

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
PF00122 (E1-E2_ATPase)

565 - 744

Pfam
PF00122 (E1-E2_ATPase)
PF00702 (Hydrolase)

762 - 1,011

Pfam
PF00702 (Hydrolase)
PR00119 (CATATPASE)

998 - 1,017

PRINTS
PR00119 (CATATPASE)

602 - 616

PRINTS
PR00119 (CATATPASE)

1,021 - 1,033

PRINTS
PR00119 (CATATPASE)

766 - 780

PRINTS
PR00119 (CATATPASE)

928 - 938

PRINTS
PR00119 (CATATPASE)
PR00942 (CUATPASEI)

428 - 448

PRINTS
PR00942 (CUATPASEI)

67 - 84

PRINTS
PR00942 (CUATPASEI)

49 - 67

PRINTS
PR00942 (CUATPASEI)

448 - 473

PRINTS
PR00942 (CUATPASEI)
PS01229 (COF_2)

998 - 1,020

PROSITE patterns
PS01229 (COF_2)
TMhelix

1,085 - 1,107

TMHMM
TMhelix (TMhelix)

1,059 - 1,081

TMHMM
TMhelix (TMhelix)

396 - 418

TMHMM
TMhelix (TMhelix)

433 - 455

TMHMM
TMhelix (TMhelix)

668 - 690

TMHMM
TMhelix (TMhelix)

467 - 489

TMHMM
TMhelix (TMhelix)

499 - 516

TMHMM
TMhelix (TMhelix)

710 - 732

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

467 - 489

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

711 - 730

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

428 - 446

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,059 - 1,082

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

392 - 416

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

736 - 756

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,088 - 1,107

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

672 - 691

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
cd02094 (P-type_ATP...)

390 - 1,095

CDD
cd02094 (P-type_ATPase_Cu-like)
mobidb-lite (disord...)

1,127 - 1,150

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 30

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

metal-binding site...

46M

metal-binding site
46M, 47T, 48C, 51C
CDD
cd00371 (HMA)

47T

metal-binding site
46M, 47T, 48C, 51C
CDD
cd00371 (HMA)

48C

metal-binding site
46M, 47T, 48C, 51C
CDD
cd00371 (HMA)

51C

metal-binding site
46M, 47T, 48C, 51C
CDD
cd00371 (HMA)
metal-binding site...

142M

metal-binding site
142M, 143T, 144C, 147C
CDD
cd00371 (HMA)

143T

metal-binding site
142M, 143T, 144C, 147C
CDD
cd00371 (HMA)

144C

metal-binding site
142M, 143T, 144C, 147C
CDD
cd00371 (HMA)

147C

metal-binding site
142M, 143T, 144C, 147C
CDD
cd00371 (HMA)
metal-binding site...

223M

metal-binding site
223M, 224T, 225C, 228C
CDD
cd00371 (HMA)

224T

metal-binding site
223M, 224T, 225C, 228C
CDD
cd00371 (HMA)

225C

metal-binding site
223M, 224T, 225C, 228C
CDD
cd00371 (HMA)

228C

metal-binding site
223M, 224T, 225C, 228C
CDD
cd00371 (HMA)
metal-binding site...

308I

metal-binding site
308I, 309T, 310N, 313S
CDD
cd00371 (HMA)

309T

metal-binding site
308I, 309T, 310N, 313S
CDD
cd00371 (HMA)

310N

metal-binding site
308I, 309T, 310N, 313S
CDD
cd00371 (HMA)

313S

metal-binding site
308I, 309T, 310N, 313S
CDD
cd00371 (HMA)
HM-ATPase signatur...

724C

HM-ATPase signature motif
724C, 725P, 726C
CDD
cd02094 (P-type_ATPase_Cu-like)

725P

HM-ATPase signature motif
724C, 725P, 726C
CDD
cd02094 (P-type_ATPase_Cu-like)

726C

HM-ATPase signature motif
724C, 725P, 726C
CDD
cd02094 (P-type_ATPase_Cu-like)
putative Cu bindin...

724C

putative Cu binding site
724C, 726C, 1,065Y
CDD
cd02094 (P-type_ATPase_Cu-like)

726C

putative Cu binding site
724C, 726C, 1,065Y
CDD
cd02094 (P-type_ATPase_Cu-like)

1,065Y

putative Cu binding site
724C, 726C, 1,065Y
CDD
cd02094 (P-type_ATPase_Cu-like)
phosphorylation si...

768D

phosphorylation site
768D
CDD
cd02094 (P-type_ATPase_Cu-like)
P-type ATPase sign...

768D

P-type ATPase signature motif
768D, 769K, 770T, 771G, 772T, 773L, 774T
CDD
cd02094 (P-type_ATPase_Cu-like)

769K

P-type ATPase signature motif
768D, 769K, 770T, 771G, 772T, 773L, 774T
CDD
cd02094 (P-type_ATPase_Cu-like)

770T

P-type ATPase signature motif
768D, 769K, 770T, 771G, 772T, 773L, 774T
CDD
cd02094 (P-type_ATPase_Cu-like)

771G

P-type ATPase signature motif
768D, 769K, 770T, 771G, 772T, 773L, 774T
CDD
cd02094 (P-type_ATPase_Cu-like)

772T

P-type ATPase signature motif
768D, 769K, 770T, 771G, 772T, 773L, 774T
CDD
cd02094 (P-type_ATPase_Cu-like)

773L

P-type ATPase signature motif
768D, 769K, 770T, 771G, 772T, 773L, 774T
CDD
cd02094 (P-type_ATPase_Cu-like)

774T

P-type ATPase signature motif
768D, 769K, 770T, 771G, 772T, 773L, 774T
CDD
cd02094 (P-type_ATPase_Cu-like)
putative ATP bindi...

768D

putative ATP binding site
768D, 769K, 770T, 845K, 865V, 866G, 867N, 896I, 936S, 937G, 938D, 960G, 963P, 966K, 1,000D, 1,003N
CDD
cd02094 (P-type_ATPase_Cu-like)

769K

putative ATP binding site
768D, 769K, 770T, 845K, 865V, 866G, 867N, 896I, 936S, 937G, 938D, 960G, 963P, 966K, 1,000D, 1,003N
CDD
cd02094 (P-type_ATPase_Cu-like)

770T

putative ATP binding site
768D, 769K, 770T, 845K, 865V, 866G, 867N, 896I, 936S, 937G, 938D, 960G, 963P, 966K, 1,000D, 1,003N
CDD
cd02094 (P-type_ATPase_Cu-like)

845K

putative ATP binding site
768D, 769K, 770T, 845K, 865V, 866G, 867N, 896I, 936S, 937G, 938D, 960G, 963P, 966K, 1,000D, 1,003N
CDD
cd02094 (P-type_ATPase_Cu-like)

865V

putative ATP binding site
768D, 769K, 770T, 845K, 865V, 866G, 867N, 896I, 936S, 937G, 938D, 960G, 963P, 966K, 1,000D, 1,003N
CDD
cd02094 (P-type_ATPase_Cu-like)

866G

putative ATP binding site
768D, 769K, 770T, 845K, 865V, 866G, 867N, 896I, 936S, 937G, 938D, 960G, 963P, 966K, 1,000D, 1,003N
CDD
cd02094 (P-type_ATPase_Cu-like)

867N

putative ATP binding site
768D, 769K, 770T, 845K, 865V, 866G, 867N, 896I, 936S, 937G, 938D, 960G, 963P, 966K, 1,000D, 1,003N
CDD
cd02094 (P-type_ATPase_Cu-like)

896I

putative ATP binding site
768D, 769K, 770T, 845K, 865V, 866G, 867N, 896I, 936S, 937G, 938D, 960G, 963P, 966K, 1,000D, 1,003N
CDD
cd02094 (P-type_ATPase_Cu-like)

936S

putative ATP binding site
768D, 769K, 770T, 845K, 865V, 866G, 867N, 896I, 936S, 937G, 938D, 960G, 963P, 966K, 1,000D, 1,003N
CDD
cd02094 (P-type_ATPase_Cu-like)

937G

putative ATP binding site
768D, 769K, 770T, 845K, 865V, 866G, 867N, 896I, 936S, 937G, 938D, 960G, 963P, 966K, 1,000D, 1,003N
CDD
cd02094 (P-type_ATPase_Cu-like)

938D

putative ATP binding site
768D, 769K, 770T, 845K, 865V, 866G, 867N, 896I, 936S, 937G, 938D, 960G, 963P, 966K, 1,000D, 1,003N
CDD
cd02094 (P-type_ATPase_Cu-like)

960G

putative ATP binding site
768D, 769K, 770T, 845K, 865V, 866G, 867N, 896I, 936S, 937G, 938D, 960G, 963P, 966K, 1,000D, 1,003N
CDD
cd02094 (P-type_ATPase_Cu-like)

963P

putative ATP binding site
768D, 769K, 770T, 845K, 865V, 866G, 867N, 896I, 936S, 937G, 938D, 960G, 963P, 966K, 1,000D, 1,003N
CDD
cd02094 (P-type_ATPase_Cu-like)

966K

putative ATP binding site
768D, 769K, 770T, 845K, 865V, 866G, 867N, 896I, 936S, 937G, 938D, 960G, 963P, 966K, 1,000D, 1,003N
CDD
cd02094 (P-type_ATPase_Cu-like)

1,000D

putative ATP binding site
768D, 769K, 770T, 845K, 865V, 866G, 867N, 896I, 936S, 937G, 938D, 960G, 963P, 966K, 1,000D, 1,003N
CDD
cd02094 (P-type_ATPase_Cu-like)

1,003N

putative ATP binding site
768D, 769K, 770T, 845K, 865V, 866G, 867N, 896I, 936S, 937G, 938D, 960G, 963P, 966K, 1,000D, 1,003N
CDD
cd02094 (P-type_ATPase_Cu-like)
putative Cu bindin...

1,066N

putative Cu binding site
1,066N, 1,093M
CDD
cd02094 (P-type_ATPase_Cu-like)

1,093M

putative Cu binding site
1,066N, 1,093M
CDD
cd02094 (P-type_ATPase_Cu-like)

Protein sequence

>MIA_01052_1
MSDEKKMLSQQLSPSPLATSGIKPSPAGSFHPSSPLSTAIFSIQGMTCGACVAAITSSLEKFNGVSSASISLVTERGQVE
FDNSVVTTSEIKERIEDCGFDANLLSETNPQPLESSALSSSPESSTQKAGIKTLDTFAIEGMTCGACVSAITSGLESLDG
VSSVTISLITERGQIEFDSSVITSDEIKERIEDCGFDARLLSETAVESSTPAKQTAIFAIAGMTCGACVSSITNNLEALK
GVTSISISLITERGSVEFDPNTVSEDQIKECIEDSGFDATLISSSESTPDTLASDEQPKLLRLKVYGITNAESSEKVENV
LRQVDGVKDAVVNLMSDEAQIYYLPSIIGPRKIVETIHNTGYDAILASTADNALQLASLSKIKQITKSKRDFFISALLGV
PVLIISRLVPSVIPFLGFLKQITLIKGFYLDDAICILLTIPIQFFVGGKFYTAAAKAIRHRAPTMDVLVCLSTSCAFFFS
LLSIIYAVVTQSTKHPHTLWETPAMIVTFITGGKYLENKAKGQTSVALSKLISLSPSTATIYSNPESYTQAMKETDSENS
IGHLETQVIPTELIESGDIVVVLPGEKIPADGTIIHGETYVDESMITGESISVSKVTGDDVICGSINGFGRIDVKVNFCG
SETRLSHIVQLVQDAQTTKTNIQRYADYISGYFVPVVIFLGIATFFVWMILSHVLGTPPRIFEGDEGKFMVCLRLCISVI
VVACPCALGLATPTAVMVGTGVGASNGILIKGGAVLETAKKVTTVLFDKTGTLTTGDMNVSSFQIDKAATQKFNLDPVTW
WKFVGCIEQSSEHPIARGTMKKVREICNIAENVQVDGTVTEFVVKVGFGVSANVKIGADTRAVNVGNVKMMDYKGVSGIP
ESVRELEKHTKGETLIIMSLDGVYAGYICIADTIRKNARETIYALKKLGLSVGMISGDHPSVARKVAKEVDIPSQLVWGG
VSPEGKLDIIDQLQSLDLESTRGYINIGGGGNEVVAMVGDGINDSPALARAALGISMANASDVAMDAADIVLLKDDSLLD
VAAAFQLCYVIFNRIRLNLLWAVIYNAIMIPIAMGCFLPLGIAMHPVFAGAAMAFSSVSVVCSSLLLQRWKRPKWMRKLY
EATNTDISSTHTSQNRRNNEALESPLASPVESKPSLFQRLRGLIRWPSKTNSSHEYTLLPR

GO term prediction

Biological Process

GO:0006812 cation transport
GO:0030001 metal ion transport

Molecular Function

GO:0000166 nucleotide binding
GO:0005507 copper ion binding
GO:0019829 cation-transporting ATPase activity
GO:0046872 metal ion binding

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features