MCA_04589_1

Protein

Length

1,145 amino acids

Gene name: CCC2A

Description: Cu(+2)-transporting P-type ATPase

Browser: contigC:3449435-3452873+

RNA-seq: read pairs 7706, FPKM 83.1, percentile rank 75.8% (100% = highest expression)

Protein function

Annotation:		CCC2A	Cu(+2)-transporting P-type ATPase
KEGG:	K17686	copA	Cu+-exporting ATPase [EC:3.6.3.54]
EGGNOG:	0PG9C	PGUG_02677	P-type ATPase
SGD closest match:	S000002678	CCC2	Copper-transporting ATPase
CGD closest match:	CAL0000193278	CCC2	Cu(2+)-transporting P-type ATPase

Protein alignments

	%id	Aln length
MIA_01052_1	60.71%	1064	MIA_01052_1
A0A0J9XKD6_GEOCN	53.33%	1080	Similar to Saccharomyces cerevisiae YDR270W CCC2 Cu(+2)-transporting P-type ATPase OS=Geotrichum candidum GN=BN980_GECA22s01341g PE=3 SV=1
UniRef50_A0A0J9XKD6	53.33%	1080	Similar to Saccharomyces cerevisiae YDR270W CCC2 Cu(+2)-transporting P-type ATPase n=2 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XKD6_GEOCN
A0A060T7N4_BLAAD	48.36%	976	ARAD1D04444p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D04444g PE=3 SV=1
A0A167FGR1_9ASCO	46.37%	992	Cu(2+)-transporting P-type ATPase CCC2 OS=Sugiyamaella lignohabitans GN=CCC2 PE=3 SV=1
Q6C7L8_YARLI	44.21%	984	YALI0D27038p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D27038g PE=3 SV=1
A0A1E3PIR6_9ASCO	43.30%	977	Heavy metal translocatin OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83177 PE=3 SV=1
Q5AG51_CANAL	39.76%	1084	Cu(2+)-transporting P-type ATPase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CCC2 PE=3 SV=1
A0A1E4TC65_9ASCO	37.15%	969	Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_19929 PE=3 SV=1
ATU2_YEAST	36.21%	1077	Copper-transporting ATPase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CCC2 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0244

Protein family membership

P-type ATPase (IPR001757)
- P-type ATPase, subfamily IB (IPR027256)

Domains and repeats

Domain
10 - 82
Heavy metal-associated domain, HMA (IPR006121)
Heavy metal-associated domain, copper ion-binding (IPR006122)
103 - 175
Heavy metal-associated domain, HMA (IPR006121)
Heavy metal-associated domain, copper ion-binding (IPR006122)
220 - 292
Heavy metal-associated domain, HMA (IPR006121)
519 - 606
P-type ATPase, A domain (IPR008250)
718 - 738
HAD-like domain (IPR023214)
737 - 1,063
HAD-like domain (IPR023214)
P-type ATPase, cytoplasmic domain N (IPR023299)
Domain
430 - 458
P-type ATPase, transmembrane domain (IPR023298)
607 - 714
P-type ATPase, transmembrane domain (IPR023298)
1,008 - 1,042
P-type ATPase, transmembrane domain (IPR023298)

1 200 400 600 800 1000 1145

Detailed signature matches

IPR001757

P-type ATPase
1. TIGR01494
  
  519 - 795
  
  TIGRFAMs
  TIGR01494 (TIGR01494)
  
  845 - 1,045
  
  TIGRFAMs
  TIGR01494 (TIGR01494)
IPR027256

P-type ATPase, subfamily IB
1. TIGR01525
  
  509 - 1,067
  
  TIGRFAMs
  TIGR01525 (TIGR01525)
IPR006121

Heavy metal-associated domain, HMA
1. PS50846 (HMA_2)
  
  13 - 79
  
  PROSITE profiles
  PS50846 (HMA_2)
  
  224 - 290
  
  PROSITE profiles
  PS50846 (HMA_2)
  
  105 - 171
  
  PROSITE profiles
  PS50846 (HMA_2)
2. PF00403 (HMA)
  
  15 - 76
  
  Pfam
  PF00403 (HMA)
  
  227 - 287
  
  Pfam
  PF00403 (HMA)
  
  107 - 168
  
  Pfam
  PF00403 (HMA)
3. cd00371 (HMA)
  
  15 - 78
  
  CDD
  cd00371 (HMA)
  
  107 - 170
  
  CDD
  cd00371 (HMA)
  
  226 - 288
  
  CDD
  cd00371 (HMA)
4. SSF55008 (HMA, heav...)
  
  220 - 292
  
  SUPERFAMILY
  SSF55008 (HMA, heavy metal-associated domain)
  
  103 - 175
  
  SUPERFAMILY
  SSF55008 (HMA, heavy metal-associated domain)
  
  10 - 82
  
  SUPERFAMILY
  SSF55008 (HMA, heavy metal-associated domain)
IPR006122

Heavy metal-associated domain, copper ion-binding
1. TIGR00003
  
  107 - 169
  
  TIGRFAMs
  TIGR00003 (TIGR00003)
  
  16 - 77
  
  TIGRFAMs
  TIGR00003 (TIGR00003)
IPR023298

P-type ATPase, transmembrane domain
1. SSF81665 (Calcium A...)
  
  430 - 458
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
  
  607 - 714
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
  
  1,008 - 1,042
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
IPR008250

P-type ATPase, A domain
1. SSF81653 (Calcium A...)
  
  519 - 606
  
  SUPERFAMILY
  SSF81653 (Calcium ATPase, transduction domain A)
IPR023214

HAD-like domain
1. SSF56784 (HAD-like)
  
  829 - 1,063
  
  SUPERFAMILY
  SSF56784 (HAD-like)
  
  718 - 738
  
  SUPERFAMILY
  SSF56784 (HAD-like)
2. G3DSA:3.40.50...
  
  863 - 1,031
  
  GENE3D
  G3DSA:3.40.50.1000 (G3DSA:3.40.50.1000)
IPR023299

P-type ATPase, cytoplasmic domain N
1. G3DSA:3.40.11...
  
  737 - 862
  
  GENE3D
  G3DSA:3.40.1110.10 (G3DSA:3.40.1110.10)
IPR017969

Heavy-metal-associated, conserved site
1. PS01047 (HMA_1)
  
  18 - 47
  
  PROSITE patterns
  PS01047 (HMA_1)
  
  110 - 139
  
  PROSITE patterns
  PS01047 (HMA_1)
IPR018303

P-type ATPase, phosphorylation site
1. PS00154 (ATPASE_E1_E2)
  
  722 - 728
  
  PROSITE patterns
  PS00154 (ATPASE_E1_E2)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

1,071 - 1,145

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

376 - 386

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 315

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

686 - 1,018

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

441 - 622

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.11...

317 - 736

GENE3D
G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)
G3DSA:3.30.70...

222 - 297

GENE3D
G3DSA:3.30.70.100 (G3DSA:3.30.70.100)

11 - 86

GENE3D
G3DSA:3.30.70.100 (G3DSA:3.30.70.100)

103 - 177

GENE3D
G3DSA:3.30.70.100 (G3DSA:3.30.70.100)
NON_CYTOPLASM... (N...)

1,043 - 1,047

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

338 - 356

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

411 - 421

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

646 - 664

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
PF00122 (E1-E2_ATPase)

515 - 698

Pfam
PF00122 (E1-E2_ATPase)
PF00702 (Hydrolase)

716 - 971

Pfam
PF00702 (Hydrolase)
PR00119 (CATATPASE)

888 - 898

PRINTS
PR00119 (CATATPASE)

720 - 734

PRINTS
PR00119 (CATATPASE)

958 - 977

PRINTS
PR00119 (CATATPASE)

556 - 570

PRINTS
PR00119 (CATATPASE)

981 - 993

PRINTS
PR00119 (CATATPASE)
PS01229 (COF_2)

958 - 980

PROSITE patterns
PS01229 (COF_2)
TMhelix

349 - 371

TMHMM
TMhelix (TMhelix)

1,019 - 1,041

TMHMM
TMhelix (TMhelix)

391 - 413

TMHMM
TMhelix (TMhelix)

622 - 644

TMHMM
TMhelix (TMhelix)

664 - 686

TMHMM
TMhelix (TMhelix)

1,045 - 1,067

TMHMM
TMhelix (TMhelix)

320 - 342

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

1,019 - 1,042

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

623 - 645

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

1,048 - 1,070

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

357 - 375

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

665 - 685

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

422 - 440

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

387 - 410

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

316 - 337

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
cd02094 (P-type_ATP...)

315 - 1,069

CDD
cd02094 (P-type_ATPase_Cu-like)
mobidb-lite (disord...)

179 - 220

MobiDB Lite
mobidb-lite (disorder_prediction)

1,087 - 1,112

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

metal-binding site...

21M

metal-binding site
21M, 22T, 23C, 26C
CDD
cd00371 (HMA)

22T

metal-binding site
21M, 22T, 23C, 26C
CDD
cd00371 (HMA)

23C

metal-binding site
21M, 22T, 23C, 26C
CDD
cd00371 (HMA)

26C

metal-binding site
21M, 22T, 23C, 26C
CDD
cd00371 (HMA)
metal-binding site...

113M

metal-binding site
113M, 114T, 115C, 118C
CDD
cd00371 (HMA)

114T

metal-binding site
113M, 114T, 115C, 118C
CDD
cd00371 (HMA)

115C

metal-binding site
113M, 114T, 115C, 118C
CDD
cd00371 (HMA)

118C

metal-binding site
113M, 114T, 115C, 118C
CDD
cd00371 (HMA)
metal-binding site...

232M

metal-binding site
232M, 233T, 234S, 237C
CDD
cd00371 (HMA)

233T

metal-binding site
232M, 233T, 234S, 237C
CDD
cd00371 (HMA)

234S

metal-binding site
232M, 233T, 234S, 237C
CDD
cd00371 (HMA)

237C

metal-binding site
232M, 233T, 234S, 237C
CDD
cd00371 (HMA)
HM-ATPase signatur...

678C

HM-ATPase signature motif
678C, 679P, 680C
CDD
cd02094 (P-type_ATPase_Cu-like)

679P

HM-ATPase signature motif
678C, 679P, 680C
CDD
cd02094 (P-type_ATPase_Cu-like)

680C

HM-ATPase signature motif
678C, 679P, 680C
CDD
cd02094 (P-type_ATPase_Cu-like)
putative Cu bindin...

678C

putative Cu binding site
678C, 680C, 1,025Y
CDD
cd02094 (P-type_ATPase_Cu-like)

680C

putative Cu binding site
678C, 680C, 1,025Y
CDD
cd02094 (P-type_ATPase_Cu-like)

1,025Y

putative Cu binding site
678C, 680C, 1,025Y
CDD
cd02094 (P-type_ATPase_Cu-like)
phosphorylation si...

722D

phosphorylation site
722D
CDD
cd02094 (P-type_ATPase_Cu-like)
P-type ATPase sign...

722D

P-type ATPase signature motif
722D, 723K, 724T, 725G, 726T, 727L, 728T
CDD
cd02094 (P-type_ATPase_Cu-like)

723K

P-type ATPase signature motif
722D, 723K, 724T, 725G, 726T, 727L, 728T
CDD
cd02094 (P-type_ATPase_Cu-like)

724T

P-type ATPase signature motif
722D, 723K, 724T, 725G, 726T, 727L, 728T
CDD
cd02094 (P-type_ATPase_Cu-like)

725G

P-type ATPase signature motif
722D, 723K, 724T, 725G, 726T, 727L, 728T
CDD
cd02094 (P-type_ATPase_Cu-like)

726T

P-type ATPase signature motif
722D, 723K, 724T, 725G, 726T, 727L, 728T
CDD
cd02094 (P-type_ATPase_Cu-like)

727L

P-type ATPase signature motif
722D, 723K, 724T, 725G, 726T, 727L, 728T
CDD
cd02094 (P-type_ATPase_Cu-like)

728T

P-type ATPase signature motif
722D, 723K, 724T, 725G, 726T, 727L, 728T
CDD
cd02094 (P-type_ATPase_Cu-like)
putative ATP bindi...

722D

putative ATP binding site
722D, 723K, 724T, 800K, 825I, 826G, 827N, 856I, 896S, 897G, 898D, 920G, 923P, 926K, 960D, 963N
CDD
cd02094 (P-type_ATPase_Cu-like)

723K

putative ATP binding site
722D, 723K, 724T, 800K, 825I, 826G, 827N, 856I, 896S, 897G, 898D, 920G, 923P, 926K, 960D, 963N
CDD
cd02094 (P-type_ATPase_Cu-like)

724T

putative ATP binding site
722D, 723K, 724T, 800K, 825I, 826G, 827N, 856I, 896S, 897G, 898D, 920G, 923P, 926K, 960D, 963N
CDD
cd02094 (P-type_ATPase_Cu-like)

800K

putative ATP binding site
722D, 723K, 724T, 800K, 825I, 826G, 827N, 856I, 896S, 897G, 898D, 920G, 923P, 926K, 960D, 963N
CDD
cd02094 (P-type_ATPase_Cu-like)

825I

putative ATP binding site
722D, 723K, 724T, 800K, 825I, 826G, 827N, 856I, 896S, 897G, 898D, 920G, 923P, 926K, 960D, 963N
CDD
cd02094 (P-type_ATPase_Cu-like)

826G

putative ATP binding site
722D, 723K, 724T, 800K, 825I, 826G, 827N, 856I, 896S, 897G, 898D, 920G, 923P, 926K, 960D, 963N
CDD
cd02094 (P-type_ATPase_Cu-like)

827N

putative ATP binding site
722D, 723K, 724T, 800K, 825I, 826G, 827N, 856I, 896S, 897G, 898D, 920G, 923P, 926K, 960D, 963N
CDD
cd02094 (P-type_ATPase_Cu-like)

856I

putative ATP binding site
722D, 723K, 724T, 800K, 825I, 826G, 827N, 856I, 896S, 897G, 898D, 920G, 923P, 926K, 960D, 963N
CDD
cd02094 (P-type_ATPase_Cu-like)

896S

putative ATP binding site
722D, 723K, 724T, 800K, 825I, 826G, 827N, 856I, 896S, 897G, 898D, 920G, 923P, 926K, 960D, 963N
CDD
cd02094 (P-type_ATPase_Cu-like)

897G

putative ATP binding site
722D, 723K, 724T, 800K, 825I, 826G, 827N, 856I, 896S, 897G, 898D, 920G, 923P, 926K, 960D, 963N
CDD
cd02094 (P-type_ATPase_Cu-like)

898D

putative ATP binding site
722D, 723K, 724T, 800K, 825I, 826G, 827N, 856I, 896S, 897G, 898D, 920G, 923P, 926K, 960D, 963N
CDD
cd02094 (P-type_ATPase_Cu-like)

920G

putative ATP binding site
722D, 723K, 724T, 800K, 825I, 826G, 827N, 856I, 896S, 897G, 898D, 920G, 923P, 926K, 960D, 963N
CDD
cd02094 (P-type_ATPase_Cu-like)

923P

putative ATP binding site
722D, 723K, 724T, 800K, 825I, 826G, 827N, 856I, 896S, 897G, 898D, 920G, 923P, 926K, 960D, 963N
CDD
cd02094 (P-type_ATPase_Cu-like)

926K

putative ATP binding site
722D, 723K, 724T, 800K, 825I, 826G, 827N, 856I, 896S, 897G, 898D, 920G, 923P, 926K, 960D, 963N
CDD
cd02094 (P-type_ATPase_Cu-like)

960D

putative ATP binding site
722D, 723K, 724T, 800K, 825I, 826G, 827N, 856I, 896S, 897G, 898D, 920G, 923P, 926K, 960D, 963N
CDD
cd02094 (P-type_ATPase_Cu-like)

963N

putative ATP binding site
722D, 723K, 724T, 800K, 825I, 826G, 827N, 856I, 896S, 897G, 898D, 920G, 923P, 926K, 960D, 963N
CDD
cd02094 (P-type_ATPase_Cu-like)
putative Cu bindin...

1,026N

putative Cu binding site
1,026N, 1,053M, 1,057S
CDD
cd02094 (P-type_ATPase_Cu-like)

1,053M

putative Cu binding site
1,026N, 1,053M, 1,057S
CDD
cd02094 (P-type_ATPase_Cu-like)

1,057S

putative Cu binding site
1,026N, 1,053M, 1,057S
CDD
cd02094 (P-type_ATPase_Cu-like)

Protein sequence

>MCA_04589_1
MSQSEKLEEPYASVVVSIQGMTCGACSAAITKGLETLPGVSSASVSLITERASVKFDPSQVTSADIIERIEDSGFDASLI
NETNSSLLQTSIQTTDTNNSPSISSATVAISGMTCGACSATITKNLEATKGIVKASVSLITERAAVEFDPTIISPEDIVE
IIEDSGFDATLISTSSLFPSTENSTPISSTTSTHRTAQASSLIPPASSSNNNNSSDPDLNPIKSVKINVYGMTSASCATS
VEDAVRELNGVKDAVANVASESVLVYYYPNQTGIRIIVETIESIGFHAILSSTADNTLQLESLSKAKAIRASREDFLISL
FLGLPVFILVRFVPSLFPFLAFLKTQVFIKGLYLDDIINVILTSPIQFYVGAKFYKATRNALRHGSPTMDVLVCISTSCA
FFFSCFIMIYNVFTRSDHRPHTFWETPAMIVTFICGGKYLENKAKGQTSAALSRLISLSPSTATIYTNSKAYLSANKITI
SEHDNIVSVSNDDGSISDKDDDVTLASDSQHSLVNDQLQTKQIPTELLESGDIVVILPGEKIPADGIVIQGETYVDESLI
TGESLSVSKVVGDTVICGSINGFGRIDVYVTSTGSDTKLSHIIQLVQDAQVSNASIQRYADTVAGYFVPVVLALAAFTFF
FWIIYSHVSSHPPKIFESSQGKFIVCLRLCISVIVVACPCALGLATPTAVMVGTGVGASNGILIKGGSVLEIANQVTTVL
FDKTGTLTTGVMNVTSYDIAPTFPNSEKHIDTASWWQYVGCLEQNSEHPVARGVMKKVREVLNIDSQTLINGQVSDFKIK
VGAGVSGHVLLKDSEKDHIPRLVIIGNIKMNETSGVNDIPDNVRIREQESMGETVIVISIDNHYAGYICLADTIRKNSKE
TVYALKKLGISVGIVSGDHPSVVKRIAKEVGVPAQLAWGGVTPEGKLEIVDQLQSKDSESSGSYSFNIGGSNEIVAMVGD
GINDSPALARAALGISMAGATDVAMDAADIVLLKENCLLDVAAALQLCRTIFKRIKLNLAWACIYNVIMMPIAMGCFLPL
GISMHPVFAGAAMAFSSVSVVCCSLLLQFWQRPKWMRELYISTDSDMHSVSSRSSNDNYETSTGNDDSPSVDMNHCEKSL
KSTVIDGLRNMFIKKPTNDYSLLPH

GO term prediction

Biological Process

GO:0006812 cation transport
GO:0030001 metal ion transport

Molecular Function

GO:0000166 nucleotide binding
GO:0005507 copper ion binding
GO:0019829 cation-transporting ATPase activity
GO:0046872 metal ion binding

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features