MIA_01045_1

Protein

Length

503 amino acids

Protein function

EGGNOG:	0PJ5U		(Mfs) transporter
SGD closest match:	S000003492	TNA1	High-affinity nicotinic acid transporter
CGD closest match:	CAL0000199600	CAALFM_CR01220WA	Uncharacterized protein

Protein alignments

	%id	Aln length	E-value
MCA_02596_1	59.763%	507	0.0	MCA_02596_1
A0A060T5B6_BLAAD	42.914%	501	4.84e-144	ARAD1C04268p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C04268g PE=4 SV=1
A0A167CP40_9ASCO	43.943%	487	5.78e-135	Tna1p OS=Sugiyamaella lignohabitans GN=TNA1 PE=4 SV=1
UniRef50_A0A167CP40	43.943%	487	1.59e-131	Tna1p n=3 Tax=Trichomonascaceae TaxID=410830 RepID=A0A167CP40_9ASCO
Q6C4F3_YARLI	30.872%	447	3.38e-64	YALI0E27247p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E27247g PE=4 SV=1
A0A0J9XA89_GEOCN	29.384%	422	5.69e-61	Similar to Saccharomyces cerevisiae YGR260W TNA1 High affinity nicotinic acid plasma membrane permease OS=Geotrichum candidum GN=BN980_GECA06s04619g PE=4 SV=1
A0A1E4THX6_9ASCO	31.807%	415	9.05e-61	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_148212 PE=4 SV=1
A0A1E3PD75_9ASCO	30.216%	417	5.08e-58	MFS general substrate transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_29178 PE=4 SV=1
TNA1_YEAST	29.073%	399	1.24e-48	High-affinity nicotinic acid transporter OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TNA1 PE=1 SV=1
Q5A896_CANAL	27.586%	435	5.23e-44	Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_CR01220WA PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0426

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
21 - 445
Major facilitator superfamily domain (IPR020846)

1 50 100 150 200 250 300 350 400 450 503

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  43 - 406
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. SSF103473 (MFS gene...)
  
  21 - 445
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
2. cd06174 (MFS)
  
  39 - 407
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

379 - 389

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

440 - 503

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

97 - 102

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

153 - 163

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

216 - 264

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 33

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

322 - 327

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

256 - 454

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

26 - 233

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

350 - 354

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

184 - 194

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

52 - 74

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

126 - 130

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

285 - 303

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

410 - 420

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

130 - 152

TMHMM
TMhelix (TMhelix)

355 - 377

TMHMM
TMhelix (TMhelix)

267 - 289

TMHMM
TMhelix (TMhelix)

299 - 321

TMHMM
TMhelix (TMhelix)

328 - 350

TMHMM
TMhelix (TMhelix)

164 - 183

TMHMM
TMhelix (TMhelix)

422 - 444

TMHMM
TMhelix (TMhelix)

193 - 215

TMHMM
TMhelix (TMhelix)

390 - 412

TMHMM
TMhelix (TMhelix)

103 - 125

TMHMM
TMhelix (TMhelix)

77 - 96

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

421 - 439

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

103 - 125

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

328 - 349

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

390 - 409

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

195 - 215

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

75 - 96

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

265 - 284

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

131 - 152

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

164 - 183

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

34 - 51

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

304 - 321

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

355 - 378

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

Residue annotation

putative substrate...

53R

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

56I

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

57G

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

58N

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

61V

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

62A

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

79L

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

82F

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

83Y

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

86Y

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

90Q

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

91W

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

93T

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

94L

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

139E

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

140A

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

143G

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

144P

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

147P

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

148Y

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

151S

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

163T

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

164G

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

167L

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

168V

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

174S

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

275N

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

278F

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

279A

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

282P

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

283I

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

286P

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

300Q

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

303T

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

307Y

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

310A

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

314T

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

364C

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

367V

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

368Y

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

371V

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

375L

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

376S

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

379G

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

391A

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

392Y

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

395L

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

396Q

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

399G

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

400Q

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

403P

putative substrate translocation pore
53R, 56I, 57G, 58N, 61V, 62A, 79L, 82F, 83Y, 86Y, 90Q, 91W, 93T, 94L, 139E, 140A, 143G, 144P, 147P, 148Y, 151S, 163T, 164G, 167L, 168V, 174S, 275N, 278F, 279A, 282P, 283I, 286P, 300Q, 303T, 307Y, 310A, 314T, 364C, 367V, 368Y, 371V, 375L, 376S, 379G, 391A, 392Y, 395L, 396Q, 399G, 400Q, 403P
CDD
cd06174 (MFS)

Protein sequence

>MIA_01045_1
MKSSIEESSKLTDPTYLLKLRYSPAEESRLVRKFDLHLMSFLCALYLVSYLDRSNIGNANVAGMSQSLNIPDAKYQWLLT
VFYLGYICFQWLTLFWKRFPPKSYVCVVVVAWGLVSTGQAVASTWAQMMVLRLLLGVFEAGFGPGVPYYLSFFYYRHEIA
FRTGLFLVVPPISSAFSGALAYLVTKNNTTDPWRLLYLVEGLPTVFLGVLCYWCIPNDSKSARGLTPREREIAAARSLRQ
IGTVERDHKINWREGISSLFDFKNICCMFMFFCINVSFASLPIYLPTIIRDMKHSSISAQGLTAPPYLVAALATLTVTYF
SDKLQQRGYFVAAAYLVAAAGYVVLATVGLDHTRIRYAATFLCCTGVYPGVGVLLSWLGNMHGGDNKRSFAYVLLQLVGQ
CGPLVGTRVYPASDTPRYTRGFWTCAACLAASAAVALWLRAHLARLNKARDETYGPLFGGASGMETVELEMVSDETTSED
GNYGETCGAGLEQESHRDFRYIL

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features