MCA_02596_1

Protein

Length

566 amino acids

RNA-seq: read pairs 173, FPKM 3.8, percentile rank 15.3% (100% = highest expression)

Protein function

EGGNOG:	0PJ5U		(Mfs) transporter
SGD closest match:	S000003492	TNA1	High-affinity nicotinic acid transporter
CGD closest match:	CAL0000199600	CAALFM_CR01220WA	Uncharacterized protein

Protein alignments

	%id	Aln length	E-value
MIA_01045_1	59.76%	507	0.0	MIA_01045_1
A0A060T5B6_BLAAD	48.90%	544	0.0	ARAD1C04268p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C04268g PE=4 SV=1
A0A167CP40_9ASCO	45.35%	527	2e-167	Tna1p OS=Sugiyamaella lignohabitans GN=TNA1 PE=4 SV=1
UniRef50_A0A167CP40	45.35%	527	5e-164	Tna1p n=3 Tax=Trichomonascaceae TaxID=410830 RepID=A0A167CP40_9ASCO
A0A0J9XA89_GEOCN	31.94%	504	2e-77	Similar to Saccharomyces cerevisiae YGR260W TNA1 High affinity nicotinic acid plasma membrane permease OS=Geotrichum candidum GN=BN980_GECA06s04619g PE=4 SV=1
A0A1E4TL67_9ASCO	30.91%	482	8e-75	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_22840 PE=4 SV=1
Q6C9D4_YARLI	31.12%	466	1e-74	YALI0D12100p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D12100g PE=4 SV=1
A0A1E3PD75_9ASCO	29.98%	497	7e-69	MFS general substrate transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_29178 PE=4 SV=1
Q5A896_CANAL	30.14%	511	9e-65	Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_CR01220WA PE=4 SV=1
TNA1_YEAST	29.90%	515	6e-63	High-affinity nicotinic acid transporter OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TNA1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0225

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
82 - 501
Major facilitator superfamily domain (IPR020846)

1 100 200 300 400 500 566

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  101 - 435
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. SSF103473 (MFS gene...)
  
  82 - 501
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
2. cd06174 (MFS)
  
  97 - 499
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

211 - 221

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

275 - 320

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

381 - 386

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 91

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

438 - 448

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

151 - 161

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

503 - 566

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

306 - 513

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

84 - 292

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

243 - 253

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

110 - 131

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

408 - 412

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

181 - 185

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

344 - 362

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

470 - 480

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

191 - 213

TMHMM
TMhelix (TMhelix)

135 - 157

TMHMM
TMhelix (TMhelix)

481 - 503

TMHMM
TMhelix (TMhelix)

449 - 471

TMHMM
TMhelix (TMhelix)

92 - 109

TMHMM
TMhelix (TMhelix)

252 - 274

TMHMM
TMhelix (TMhelix)

220 - 242

TMHMM
TMhelix (TMhelix)

326 - 348

TMHMM
TMhelix (TMhelix)

358 - 380

TMHMM
TMhelix (TMhelix)

162 - 181

TMHMM
TMhelix (TMhelix)

414 - 436

TMHMM
TMhelix (TMhelix)

387 - 404

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

481 - 502

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

363 - 380

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

321 - 343

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

449 - 469

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

413 - 437

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

186 - 210

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

162 - 180

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

254 - 274

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

222 - 242

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

132 - 150

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

92 - 109

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

387 - 407

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
mobidb-lite (disord...)

49 - 68

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 42

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative substrate...

111R

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

114I

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

115G

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

116N

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

118N

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

119T

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

137L

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

140F

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

141Y

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

144Y

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

148Q

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

149W

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

151T

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

152A

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

197E

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

198A

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

201G

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

202P

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

205P

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

206Y

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

209S

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

221T

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

222G

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

225M

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

226A

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

232S

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

334N

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

337F

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

338A

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

341P

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

342V

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

345P

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

358A

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

362T

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

366Y

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

369A

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

373T

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

423C

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

426V

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

427F

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

430V

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

434L

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

435S

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

438G

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

450G

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

451Y

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

454L

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

455Q

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

458G

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

459Q

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

462P

putative substrate translocation pore
111R, 114I, 115G, 116N, 118N, 119T, 137L, 140F, 141Y, 144Y, 148Q, 149W, 151T, 152A, 197E, 198A, 201G, 202P, 205P, 206Y, 209S, 221T, 222G, 225M, 226A, 232S, 334N, 337F, 338A, 341P, 342V, 345P, 358A, 362T, 366Y, 369A, 373T, 423C, 426V, 427F, 430V, 434L, 435S, 438G, 450G, 451Y, 454L, 455Q, 458G, 459Q, 462P
CDD
cd06174 (MFS)

Protein sequence

>MCA_02596_1
MSQNNIGNSLQPDGLTSGPTPQDNSSPVQHSNEKLSEIRHISHSSNISLSENKKEVRTTTDTVPDNDQNVDPNYLLTLKY
SKEEENKLVRKYDLHLLTFLCAIYMVSYLDRSNIGNANTAGLSKDIGMSDKQYQWVLTIFYIAYICFQWTTALWKMFRPS
RYVYLVVIGWGITSTLQAVVSKWSHVMVIRFLLGIFEAGFGPGVPYYLSFFYYRHEIALRTGIFMAVPPISSAFSGALAY
GITKNKTSIAPWKILFIVEGIPTVLLGVLCFWMIPDDSRSMRVLSEREKEIAAARTLRQIGTIERDHKIDWREGLRSLFD
IKIICCMFMYFAINVSFASLPVYLPTIIKSMGYSSVNAQGLTAPPYILAAICTLAATYTSDKIKQRGIFVTLGFTISAAG
YLILANISEHQTAVRYFAVYLCCAGVFPCVAVLLSWVGNMQGGDGKKNFGYIFLQAVGQCGPLLGTRIYPASDGPRFRKG
FWINFGFLSASAVVSIFLRTYLTHLNKKLDEKYGKPEFTAEQLIEMQTRPMQEGEEYMNRMDNSDKSVMETVAIESEANK
NFRYIY

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features