Protein
MIA_01009_1
Length
489 amino acids
Browser: contig01:2897170-2898814-
Protein function
| EGGNOG: | 0PPMY | BNA7 | Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites (By similarity) |
|---|---|---|---|
| CGD closest match: | CAL0000192193 | BNA7 | Kynurenine formamidase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MCA_00778_1 | 56.85% | 343 | 5e-120 | MCA_00778_1 |
| A0A0J9X963_GEOCN | 59.50% | 279 | 7e-110 | Similar to Saccharomyces cerevisiae YDR428C BNA7 Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine OS=Geotrichum candidum GN=BN980_GECA06s03288g PE=4 SV=1 |
| Q6CCT4_YARLI | 54.84% | 279 | 3e-102 | YALI0C06732p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C06732g PE=4 SV=1 |
| UniRef50_Q6CCT4 | 54.84% | 279 | 6e-99 | YALI0C06732p n=4 Tax=Saccharomycetales TaxID=4892 RepID=Q6CCT4_YARLI |
| A0A1E3PFT8_9ASCO | 50.87% | 289 | 6e-90 | Alpha/beta-hydrolase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_52570 PE=4 SV=1 |
| A0A167D7X6_9ASCO | 32.30% | 161 | 8e-25 | Kynurenine formamidase OS=Sugiyamaella lignohabitans GN=BNA7 PE=3 SV=1 |
| A0A060TDW1_BLAAD | 30.92% | 152 | 7e-19 | ARAD1D03190p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D03190g PE=4 SV=1 |
| KFA_CANAL | 31.21% | 157 | 3e-18 | Kynurenine formamidase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=BNA7 PE=3 SV=1 |
| A0A1E4TGT7_9ASCO | 35.21% | 142 | 8e-16 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_26848 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0827
Protein family membership
None predicted.
Domains and repeats
-
Domain
1
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489
Detailed signature matches
no IPR
Unintegrated signatures
-
mobidb-lite (disord...)
Protein sequence
>MIA_01009_1 MPLIFHTDDQDTRTLSSSSSLSSIRSVRDNSSGASLLSSRPSSPASSGTEALSSGIALMSVRDAPSSMAINGAGRIGEEG AASTAAGGRLGSHTPSGVYTPGSAVTVRSSSHISEEQPPLDEEEDKGDEGDGRLNVALRRREEEEEGSIGNNSPSSNLHS TSTSSSNSSGGSPHQTFHGIHRSGSTNTRAYSLDETRSLSIVTFLPRATRPAPLTLPYKSSPNPFHTLDLYLPASGLAPS TPWFFFLHGGYWQDATQSKDVGSVILSRLPAHWAGASIDYRLSPEIAHPGHLDDVKRAFKFVRSAYDISKAVIMAHGAGA CIAYQYIFSELAMGKGDWISHVITSGGVYDLPELAKDSPYYYRFIADAYGNDQEHWYDLSPQNFEWESVYGDEQADEPNQ GGEAQEDGKRAHRMDLTLVHSKFDLIVPIRQSLRFEDRLTEAGFRCSLRLLSIDGHDTVLETTELALIALEVCKHMDEEE ERLLGMHLG
GO term prediction
Biological Process
GO:0008152 metabolic process
Molecular Function
GO:0016787 hydrolase activity
Cellular Component
None predicted.