MIA_00996_1

Protein

Length

2,391 amino acids

Protein function

EGGNOG:	0PGIW	MEC1	Serine threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence ST -Q. Recruited to DNA lesions in order to initiate the DNA repair by homologous recombination. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Required for cell growth and meiotic recombination (By similarity)
SGD closest match:	S000000340	MEC1	Serine/threonine-protein kinase MEC1
CGD closest match:	CAL0000200852	MEC1	Serine/threonine-protein kinase MEC1

Protein alignments

	%id	Aln length	E-value
MCA_00799_1	46.796%	2419	0.0	MCA_00799_1
A0A0J9X9H5_GEOCN	36.713%	2446	0.0	Similar to Saccharomyces cerevisiae YBR136W MEC1 Genome integrity checkpoint protein and PI kinase superfamily member OS=Geotrichum candidum GN=BN980_GECA05s01946g PE=3 SV=1
UniRef50_A0A0J9X9H5	36.713%	2446	0.0	Similar to Saccharomyces cerevisiae YBR136W MEC1 Genome integrity checkpoint protein and PI kinase superfamily member n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X9H5_GEOCN
A0A060TBG6_BLAAD	37.979%	2009	0.0	ARAD1D35068p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D35068g PE=3 SV=1
A0A1E3PHR0_9ASCO	33.720%	1895	0.0	Uncharacterized protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_4642 PE=3 SV=1
A0A161HFJ3_9ASCO	36.297%	1496	0.0	Protein kinase MEC1 OS=Sugiyamaella lignohabitans GN=MEC1 PE=4 SV=1
A0A1E4TKB1_9ASCO	28.914%	1961	0.0	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_23151 PE=3 SV=1
ATR_CANAL	27.526%	1900	0.0	Serine/threonine-protein kinase MEC1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MEC1 PE=3 SV=2
ATR_YEAST	26.396%	2095	0.0	Serine/threonine-protein kinase MEC1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MEC1 PE=1 SV=1
Q6C0Z0_YARLI	28.798%	1389	4.26e-153	YALI0F20636p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F20636g PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0392

Protein family membership

None predicted.

Domains and repeats

Domain
22 - 986
Armadillo-type fold (IPR016024)
Armadillo-like helical (IPR011989)
999 - 1,179
Armadillo-type fold (IPR016024)
1,352 - 1,935
PIK-related kinase (IPR014009)
PIK-related kinase, FAT (IPR003151)
2,036 - 2,391
Protein kinase-like domain (IPR011009)
Phosphatidylinositol 3-/4-kinase, catalytic domain (IPR000403)
Domain
834 - 940
UME domain (IPR012993)
1,353 - 1,817
Tetratricopeptide-like helical domain (IPR011990)
2,359 - 2,391
FATC domain (IPR003152)

1 500 1000 1500 2000 2391

Detailed signature matches

IPR016024

Armadillo-type fold
1. SSF48371 (ARM repeat)
  
  999 - 1,179
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  831 - 967
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  488 - 730
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
IPR011989

Armadillo-like helical
1. G3DSA:1.25.10.10
  
  22 - 986
  
  GENE3D
  G3DSA:1.25.10.10 (G3DSA:1.25.10.10)
IPR012993

UME domain
1. PF08064 (UME)
  
  837 - 938
  
  Pfam
  PF08064 (UME)
2. SM00802 (UME_cls)
  
  834 - 940
  
  SMART
  SM00802 (UME_cls)
IPR014009

PIK-related kinase
1. PS51189 (FAT)
  
  1,352 - 1,935
  
  PROSITE profiles
  PS51189 (FAT)
IPR011990

Tetratricopeptide-like helical domain
1. G3DSA:1.25.40.10
  
  1,353 - 1,817
  
  GENE3D
  G3DSA:1.25.40.10 (G3DSA:1.25.40.10)
IPR003151

PIK-related kinase, FAT
1. PF02259 (FAT)
  
  1,492 - 1,834
  
  Pfam
  PF02259 (FAT)
IPR011009

Protein kinase-like domain
1. SSF56112 (Protein k...)
  
  2,036 - 2,154
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
  
  2,184 - 2,352
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR000403

Phosphatidylinositol 3-/4-kinase, catalytic domain
1. PS50290 (PI3_4_KINA...)
  
  2,077 - 2,391
  
  PROSITE profiles
  PS50290 (PI3_4_KINASE_3)
2. SM00146 (pi3k_hr1_6)
  
  2,078 - 2,380
  
  SMART
  SM00146 (pi3k_hr1_6)
3. PF00454 (PI3_PI4_ki...)
  
  2,077 - 2,319
  
  Pfam
  PF00454 (PI3_PI4_kinase)
4. G3DSA:1.10.10...
  
  2,169 - 2,358
  
  GENE3D
  G3DSA:1.10.1070.11 (G3DSA:1.10.1070.11)
IPR003152

FATC domain
1. SM01343 (FATC_2)
  
  2,359 - 2,391
  
  SMART
  SM01343 (FATC_2)
2. PF02260 (FATC)
  
  2,360 - 2,391
  
  Pfam
  PF02260 (FATC)
3. PS51190 (FATC)
  
  2,359 - 2,391
  
  PROSITE profiles
  PS51190 (FATC)
IPR018936

Phosphatidylinositol 3/4-kinase, conserved site
1. PS00916 (PI3_4_KINA...)
  
  2,213 - 2,233
  
  PROSITE patterns
  PS00916 (PI3_4_KINASE_2)

no IPR

Unintegrated signatures

G3DSA:3.30.10...

1,963 - 2,136

GENE3D
G3DSA:3.30.1010.10 (G3DSA:3.30.1010.10)
cd00892 (PIKKc_ATR)

2,048 - 2,320

CDD
cd00892 (PIKKc_ATR)

Residue annotation

ATP binding site c...

2,058M

ATP binding site
2,058M, 2,060S, 2,061L, 2,062Q, 2,064P, 2,080L, 2,082K, 2,085D, 2,120Y, 2,132I, 2,133E, 2,134W, 2,135V, 2,140P, 2,233N, 2,235L, 2,246V, 2,247D
CDD
cd00892 (PIKKc_ATR)

2,060S

ATP binding site
2,058M, 2,060S, 2,061L, 2,062Q, 2,064P, 2,080L, 2,082K, 2,085D, 2,120Y, 2,132I, 2,133E, 2,134W, 2,135V, 2,140P, 2,233N, 2,235L, 2,246V, 2,247D
CDD
cd00892 (PIKKc_ATR)

2,061L

ATP binding site
2,058M, 2,060S, 2,061L, 2,062Q, 2,064P, 2,080L, 2,082K, 2,085D, 2,120Y, 2,132I, 2,133E, 2,134W, 2,135V, 2,140P, 2,233N, 2,235L, 2,246V, 2,247D
CDD
cd00892 (PIKKc_ATR)

2,062Q

ATP binding site
2,058M, 2,060S, 2,061L, 2,062Q, 2,064P, 2,080L, 2,082K, 2,085D, 2,120Y, 2,132I, 2,133E, 2,134W, 2,135V, 2,140P, 2,233N, 2,235L, 2,246V, 2,247D
CDD
cd00892 (PIKKc_ATR)

2,064P

ATP binding site
2,058M, 2,060S, 2,061L, 2,062Q, 2,064P, 2,080L, 2,082K, 2,085D, 2,120Y, 2,132I, 2,133E, 2,134W, 2,135V, 2,140P, 2,233N, 2,235L, 2,246V, 2,247D
CDD
cd00892 (PIKKc_ATR)

2,080L

ATP binding site
2,058M, 2,060S, 2,061L, 2,062Q, 2,064P, 2,080L, 2,082K, 2,085D, 2,120Y, 2,132I, 2,133E, 2,134W, 2,135V, 2,140P, 2,233N, 2,235L, 2,246V, 2,247D
CDD
cd00892 (PIKKc_ATR)

2,082K

ATP binding site
2,058M, 2,060S, 2,061L, 2,062Q, 2,064P, 2,080L, 2,082K, 2,085D, 2,120Y, 2,132I, 2,133E, 2,134W, 2,135V, 2,140P, 2,233N, 2,235L, 2,246V, 2,247D
CDD
cd00892 (PIKKc_ATR)

2,085D

ATP binding site
2,058M, 2,060S, 2,061L, 2,062Q, 2,064P, 2,080L, 2,082K, 2,085D, 2,120Y, 2,132I, 2,133E, 2,134W, 2,135V, 2,140P, 2,233N, 2,235L, 2,246V, 2,247D
CDD
cd00892 (PIKKc_ATR)

2,120Y

ATP binding site
2,058M, 2,060S, 2,061L, 2,062Q, 2,064P, 2,080L, 2,082K, 2,085D, 2,120Y, 2,132I, 2,133E, 2,134W, 2,135V, 2,140P, 2,233N, 2,235L, 2,246V, 2,247D
CDD
cd00892 (PIKKc_ATR)

2,132I

ATP binding site
2,058M, 2,060S, 2,061L, 2,062Q, 2,064P, 2,080L, 2,082K, 2,085D, 2,120Y, 2,132I, 2,133E, 2,134W, 2,135V, 2,140P, 2,233N, 2,235L, 2,246V, 2,247D
CDD
cd00892 (PIKKc_ATR)

2,133E

ATP binding site
2,058M, 2,060S, 2,061L, 2,062Q, 2,064P, 2,080L, 2,082K, 2,085D, 2,120Y, 2,132I, 2,133E, 2,134W, 2,135V, 2,140P, 2,233N, 2,235L, 2,246V, 2,247D
CDD
cd00892 (PIKKc_ATR)

2,134W

ATP binding site
2,058M, 2,060S, 2,061L, 2,062Q, 2,064P, 2,080L, 2,082K, 2,085D, 2,120Y, 2,132I, 2,133E, 2,134W, 2,135V, 2,140P, 2,233N, 2,235L, 2,246V, 2,247D
CDD
cd00892 (PIKKc_ATR)

2,135V

ATP binding site
2,058M, 2,060S, 2,061L, 2,062Q, 2,064P, 2,080L, 2,082K, 2,085D, 2,120Y, 2,132I, 2,133E, 2,134W, 2,135V, 2,140P, 2,233N, 2,235L, 2,246V, 2,247D
CDD
cd00892 (PIKKc_ATR)

2,140P

ATP binding site
2,058M, 2,060S, 2,061L, 2,062Q, 2,064P, 2,080L, 2,082K, 2,085D, 2,120Y, 2,132I, 2,133E, 2,134W, 2,135V, 2,140P, 2,233N, 2,235L, 2,246V, 2,247D
CDD
cd00892 (PIKKc_ATR)

2,233N

ATP binding site
2,058M, 2,060S, 2,061L, 2,062Q, 2,064P, 2,080L, 2,082K, 2,085D, 2,120Y, 2,132I, 2,133E, 2,134W, 2,135V, 2,140P, 2,233N, 2,235L, 2,246V, 2,247D
CDD
cd00892 (PIKKc_ATR)

2,235L

ATP binding site
2,058M, 2,060S, 2,061L, 2,062Q, 2,064P, 2,080L, 2,082K, 2,085D, 2,120Y, 2,132I, 2,133E, 2,134W, 2,135V, 2,140P, 2,233N, 2,235L, 2,246V, 2,247D
CDD
cd00892 (PIKKc_ATR)

2,246V

ATP binding site
2,058M, 2,060S, 2,061L, 2,062Q, 2,064P, 2,080L, 2,082K, 2,085D, 2,120Y, 2,132I, 2,133E, 2,134W, 2,135V, 2,140P, 2,233N, 2,235L, 2,246V, 2,247D
CDD
cd00892 (PIKKc_ATR)

2,247D

ATP binding site
2,058M, 2,060S, 2,061L, 2,062Q, 2,064P, 2,080L, 2,082K, 2,085D, 2,120Y, 2,132I, 2,133E, 2,134W, 2,135V, 2,140P, 2,233N, 2,235L, 2,246V, 2,247D
CDD
cd00892 (PIKKc_ATR)
catalytic loop cd0...

2,225G

catalytic loop
2,225G, 2,226V, 2,227G, 2,228D, 2,229R, 2,230H, 2,231G, 2,232E, 2,233N
CDD
cd00892 (PIKKc_ATR)

2,226V

catalytic loop
2,225G, 2,226V, 2,227G, 2,228D, 2,229R, 2,230H, 2,231G, 2,232E, 2,233N
CDD
cd00892 (PIKKc_ATR)

2,227G

catalytic loop
2,225G, 2,226V, 2,227G, 2,228D, 2,229R, 2,230H, 2,231G, 2,232E, 2,233N
CDD
cd00892 (PIKKc_ATR)

2,228D

catalytic loop
2,225G, 2,226V, 2,227G, 2,228D, 2,229R, 2,230H, 2,231G, 2,232E, 2,233N
CDD
cd00892 (PIKKc_ATR)

2,229R

catalytic loop
2,225G, 2,226V, 2,227G, 2,228D, 2,229R, 2,230H, 2,231G, 2,232E, 2,233N
CDD
cd00892 (PIKKc_ATR)

2,230H

catalytic loop
2,225G, 2,226V, 2,227G, 2,228D, 2,229R, 2,230H, 2,231G, 2,232E, 2,233N
CDD
cd00892 (PIKKc_ATR)

2,231G

catalytic loop
2,225G, 2,226V, 2,227G, 2,228D, 2,229R, 2,230H, 2,231G, 2,232E, 2,233N
CDD
cd00892 (PIKKc_ATR)

2,232E

catalytic loop
2,225G, 2,226V, 2,227G, 2,228D, 2,229R, 2,230H, 2,231G, 2,232E, 2,233N
CDD
cd00892 (PIKKc_ATR)

2,233N

catalytic loop
2,225G, 2,226V, 2,227G, 2,228D, 2,229R, 2,230H, 2,231G, 2,232E, 2,233N
CDD
cd00892 (PIKKc_ATR)
activation loop (A...

2,247D

activation loop (A-loop)
2,247D, 2,248F, 2,249D, 2,250C, 2,251L, 2,252F, 2,253D, 2,254K, 2,255G, 2,256K, 2,257D, 2,258L, 2,259E, 2,260M, 2,261P, 2,262E, 2,263L, 2,264V, 2,265P, 2,266F, 2,267R, 2,268M, 2,269T
CDD
cd00892 (PIKKc_ATR)

2,248F

activation loop (A-loop)
2,247D, 2,248F, 2,249D, 2,250C, 2,251L, 2,252F, 2,253D, 2,254K, 2,255G, 2,256K, 2,257D, 2,258L, 2,259E, 2,260M, 2,261P, 2,262E, 2,263L, 2,264V, 2,265P, 2,266F, 2,267R, 2,268M, 2,269T
CDD
cd00892 (PIKKc_ATR)

2,249D

activation loop (A-loop)
2,247D, 2,248F, 2,249D, 2,250C, 2,251L, 2,252F, 2,253D, 2,254K, 2,255G, 2,256K, 2,257D, 2,258L, 2,259E, 2,260M, 2,261P, 2,262E, 2,263L, 2,264V, 2,265P, 2,266F, 2,267R, 2,268M, 2,269T
CDD
cd00892 (PIKKc_ATR)

2,250C

activation loop (A-loop)
2,247D, 2,248F, 2,249D, 2,250C, 2,251L, 2,252F, 2,253D, 2,254K, 2,255G, 2,256K, 2,257D, 2,258L, 2,259E, 2,260M, 2,261P, 2,262E, 2,263L, 2,264V, 2,265P, 2,266F, 2,267R, 2,268M, 2,269T
CDD
cd00892 (PIKKc_ATR)

2,251L

activation loop (A-loop)
2,247D, 2,248F, 2,249D, 2,250C, 2,251L, 2,252F, 2,253D, 2,254K, 2,255G, 2,256K, 2,257D, 2,258L, 2,259E, 2,260M, 2,261P, 2,262E, 2,263L, 2,264V, 2,265P, 2,266F, 2,267R, 2,268M, 2,269T
CDD
cd00892 (PIKKc_ATR)

2,252F

activation loop (A-loop)
2,247D, 2,248F, 2,249D, 2,250C, 2,251L, 2,252F, 2,253D, 2,254K, 2,255G, 2,256K, 2,257D, 2,258L, 2,259E, 2,260M, 2,261P, 2,262E, 2,263L, 2,264V, 2,265P, 2,266F, 2,267R, 2,268M, 2,269T
CDD
cd00892 (PIKKc_ATR)

2,253D

activation loop (A-loop)
2,247D, 2,248F, 2,249D, 2,250C, 2,251L, 2,252F, 2,253D, 2,254K, 2,255G, 2,256K, 2,257D, 2,258L, 2,259E, 2,260M, 2,261P, 2,262E, 2,263L, 2,264V, 2,265P, 2,266F, 2,267R, 2,268M, 2,269T
CDD
cd00892 (PIKKc_ATR)

2,254K

activation loop (A-loop)
2,247D, 2,248F, 2,249D, 2,250C, 2,251L, 2,252F, 2,253D, 2,254K, 2,255G, 2,256K, 2,257D, 2,258L, 2,259E, 2,260M, 2,261P, 2,262E, 2,263L, 2,264V, 2,265P, 2,266F, 2,267R, 2,268M, 2,269T
CDD
cd00892 (PIKKc_ATR)

2,255G

activation loop (A-loop)
2,247D, 2,248F, 2,249D, 2,250C, 2,251L, 2,252F, 2,253D, 2,254K, 2,255G, 2,256K, 2,257D, 2,258L, 2,259E, 2,260M, 2,261P, 2,262E, 2,263L, 2,264V, 2,265P, 2,266F, 2,267R, 2,268M, 2,269T
CDD
cd00892 (PIKKc_ATR)

2,256K

activation loop (A-loop)
2,247D, 2,248F, 2,249D, 2,250C, 2,251L, 2,252F, 2,253D, 2,254K, 2,255G, 2,256K, 2,257D, 2,258L, 2,259E, 2,260M, 2,261P, 2,262E, 2,263L, 2,264V, 2,265P, 2,266F, 2,267R, 2,268M, 2,269T
CDD
cd00892 (PIKKc_ATR)

2,257D

activation loop (A-loop)
2,247D, 2,248F, 2,249D, 2,250C, 2,251L, 2,252F, 2,253D, 2,254K, 2,255G, 2,256K, 2,257D, 2,258L, 2,259E, 2,260M, 2,261P, 2,262E, 2,263L, 2,264V, 2,265P, 2,266F, 2,267R, 2,268M, 2,269T
CDD
cd00892 (PIKKc_ATR)

2,258L

activation loop (A-loop)
2,247D, 2,248F, 2,249D, 2,250C, 2,251L, 2,252F, 2,253D, 2,254K, 2,255G, 2,256K, 2,257D, 2,258L, 2,259E, 2,260M, 2,261P, 2,262E, 2,263L, 2,264V, 2,265P, 2,266F, 2,267R, 2,268M, 2,269T
CDD
cd00892 (PIKKc_ATR)

2,259E

activation loop (A-loop)
2,247D, 2,248F, 2,249D, 2,250C, 2,251L, 2,252F, 2,253D, 2,254K, 2,255G, 2,256K, 2,257D, 2,258L, 2,259E, 2,260M, 2,261P, 2,262E, 2,263L, 2,264V, 2,265P, 2,266F, 2,267R, 2,268M, 2,269T
CDD
cd00892 (PIKKc_ATR)

2,260M

activation loop (A-loop)
2,247D, 2,248F, 2,249D, 2,250C, 2,251L, 2,252F, 2,253D, 2,254K, 2,255G, 2,256K, 2,257D, 2,258L, 2,259E, 2,260M, 2,261P, 2,262E, 2,263L, 2,264V, 2,265P, 2,266F, 2,267R, 2,268M, 2,269T
CDD
cd00892 (PIKKc_ATR)

2,261P

activation loop (A-loop)
2,247D, 2,248F, 2,249D, 2,250C, 2,251L, 2,252F, 2,253D, 2,254K, 2,255G, 2,256K, 2,257D, 2,258L, 2,259E, 2,260M, 2,261P, 2,262E, 2,263L, 2,264V, 2,265P, 2,266F, 2,267R, 2,268M, 2,269T
CDD
cd00892 (PIKKc_ATR)

2,262E

activation loop (A-loop)
2,247D, 2,248F, 2,249D, 2,250C, 2,251L, 2,252F, 2,253D, 2,254K, 2,255G, 2,256K, 2,257D, 2,258L, 2,259E, 2,260M, 2,261P, 2,262E, 2,263L, 2,264V, 2,265P, 2,266F, 2,267R, 2,268M, 2,269T
CDD
cd00892 (PIKKc_ATR)

2,263L

activation loop (A-loop)
2,247D, 2,248F, 2,249D, 2,250C, 2,251L, 2,252F, 2,253D, 2,254K, 2,255G, 2,256K, 2,257D, 2,258L, 2,259E, 2,260M, 2,261P, 2,262E, 2,263L, 2,264V, 2,265P, 2,266F, 2,267R, 2,268M, 2,269T
CDD
cd00892 (PIKKc_ATR)

2,264V

activation loop (A-loop)
2,247D, 2,248F, 2,249D, 2,250C, 2,251L, 2,252F, 2,253D, 2,254K, 2,255G, 2,256K, 2,257D, 2,258L, 2,259E, 2,260M, 2,261P, 2,262E, 2,263L, 2,264V, 2,265P, 2,266F, 2,267R, 2,268M, 2,269T
CDD
cd00892 (PIKKc_ATR)

2,265P

activation loop (A-loop)
2,247D, 2,248F, 2,249D, 2,250C, 2,251L, 2,252F, 2,253D, 2,254K, 2,255G, 2,256K, 2,257D, 2,258L, 2,259E, 2,260M, 2,261P, 2,262E, 2,263L, 2,264V, 2,265P, 2,266F, 2,267R, 2,268M, 2,269T
CDD
cd00892 (PIKKc_ATR)

2,266F

activation loop (A-loop)
2,247D, 2,248F, 2,249D, 2,250C, 2,251L, 2,252F, 2,253D, 2,254K, 2,255G, 2,256K, 2,257D, 2,258L, 2,259E, 2,260M, 2,261P, 2,262E, 2,263L, 2,264V, 2,265P, 2,266F, 2,267R, 2,268M, 2,269T
CDD
cd00892 (PIKKc_ATR)

2,267R

activation loop (A-loop)
2,247D, 2,248F, 2,249D, 2,250C, 2,251L, 2,252F, 2,253D, 2,254K, 2,255G, 2,256K, 2,257D, 2,258L, 2,259E, 2,260M, 2,261P, 2,262E, 2,263L, 2,264V, 2,265P, 2,266F, 2,267R, 2,268M, 2,269T
CDD
cd00892 (PIKKc_ATR)

2,268M

activation loop (A-loop)
2,247D, 2,248F, 2,249D, 2,250C, 2,251L, 2,252F, 2,253D, 2,254K, 2,255G, 2,256K, 2,257D, 2,258L, 2,259E, 2,260M, 2,261P, 2,262E, 2,263L, 2,264V, 2,265P, 2,266F, 2,267R, 2,268M, 2,269T
CDD
cd00892 (PIKKc_ATR)

2,269T

activation loop (A-loop)
2,247D, 2,248F, 2,249D, 2,250C, 2,251L, 2,252F, 2,253D, 2,254K, 2,255G, 2,256K, 2,257D, 2,258L, 2,259E, 2,260M, 2,261P, 2,262E, 2,263L, 2,264V, 2,265P, 2,266F, 2,267R, 2,268M, 2,269T
CDD
cd00892 (PIKKc_ATR)

Protein sequence

>MIA_00996_1
MPQNSAGELGQLNVSEKSLVSNSTQHNEINKLLENLLSMKIDEFDVYECMKLILGISKGVICPILAHKQTSLSEDLTAQV
IMCLKAIIRLINFRPNVLYCEIGEQNTPYLYEFVIPNVISLFQYRLEIIDQLLDTCLTSILSSSGSNTALYKSTFSLHAY
YFQILNKLAEFSRTEVITDPSIFPPELNFFQIKDDSLPLKISVRLLLIFFTALDSSSIFLEMTTPSTFAFLFDLTSNAFN
TFKFKAAELSFNMDKIHFFFSQIFHVAFKVNSSSRSSWCNLTLQWLCLIRQLSVKSSISSELDMKATSLAIELIELIVTN
QTGGVLSSIIQIDYKSSKKGNVSKQTNISKALNIISGLLNSKELGPYDANFVSSLGFTDPILFKKVQALQNVTQRATFTL
SSCTPGFQSNGNLFSKIFDDLPFSNKRIEGPDELKLFIINNFTSLSLKDKVYLISRVGLSACFMVGTLDVSNMRCKNCDC
GIISVSRDRPFLPVYESIFNVIIKLPGFFDSPVLRLETLKAFRRVVSGMDVSFNPKNDLGSWISSSLRSTNRDIRIAASM
ILPFFASNSKSSTRVIDVLSKININSEKYLIETTIMAWAQLAKNAESDTLNIILVKLIDFFALPSTFSTSLVMYYIRSIA
RYKNLSTWNLFSPFWKTISLSVIKQKYSTPIVLSRFCRLLDIPVDEFLSRTHSYTVPYLIWNGDKESIESIASSLKYHVE
QLIVSDLKNIISVSFLNEIKYDEKASKFGELSRAKLINICDTFQRLDFMGTITSDCLEISVEVLKRYHSNNLNDTMSDEE
AKKKTINDLSQIFSFICVAKVRKAKKNATLRSNMSEFLDENILGILHFLTGAILNPSEKTSHIEQLECLNGLANLIICSG
NIFFKAIPQICSLLQAALEISVLQAETIKVWALVFRSIKTSDLEQLTDLIFSVVIQKWDFFTKEAQKSAKDLLNYLVFVE
KDEMKHIIQTKGVPHTYGMLPDLADIHQQITTMVIPPQLNIHQLNPLLKRIFNENVYVVRQTILEIKQFLMRNQPCISEA
MNIPILRKNYIDRLYRVLLNTSYQFHDSKTDIPYLCSQCLGIIGAADPSKIDITVENRSVIVTHNFNDAKESISFVVYFL
ENYLVKAFRASTDPNAQVYLAYGIQEYLKFCGLYYNSNDGGRLNELWDYFSPSSQSLMLPMRTSCYTLTASPAQEPETYP
IFHNGIDHFKWIERFTIDLLQKAKTNINSEQIFKVFRKFITYLDTSVYNFILPYVALNVVLGESAEQRKNIVKELLLILS
TSNDNNKNSNMKRFYSSVFSVIDYFNKWKRHRQQFLGKNSGRSKSSRSGNIVLNDKPIGIIDSLMSNISPSLMAQRSYEC
ESYPRAIMYWEQFLDKNPNADSVVREDIYSKFMEIYANINDPDSLEGAARSFKELSVPRKILQMENTGRWDDALECYESL
SKSPEWEWDSEPGYHMFRCMKQGGNYDNLLSLLDSMMLTQEAIPEKLLSVGIETSWLAGDFKKMETLLSQVQHDSKIDFS
FEVNIARALICLQRSDFQEFRNRIEMARWGVSENLASSPVSSLYQCHESLVRLHGLADLELVGDLSSCFSQGGVDHRTMS
TGFNRRLDLVGSNYEAKCYLLALRRSAVLSTNLPYAKEEAQITWIYSSRFARKLDQYKLALRASLNGLSNNQFTNYEAYI
EYAKLFCSQDDYYEAIKCLDSMVPGGLIQYLSKKDNEASNSQSRKDNDGAVIDRYLAKSALLQTKWLDMSGEGKSSEIMQ
RYALVARVYPQWEKSHYYSAKYYNRIYDSQLAQSPENRSKDFYSGDYISLMVRNYAMALPYGIKYVYETLPKMISLWLDF
ADNINKFEDTPPYSKEVIPEISFNRKENLAKINDFLLKFVERVPAFVFYMAMPQLMSRIGISESKASIVLHKIIINTVKA
YPRQALWYVFGKANSQNNIRNTEIGKIIDALRSKTPVPATSQIQAESLSTLLISGQKFVNVLTQFAYVKVSKMPASNTLK
LKDFKFDMSSIPCGLVVPVQQCMRAVLPNVPEGMKHHNPFPKSSVITIANIDDTVNIMQSLQKPKKITIFGSNGKRYRLL
CKSHDDVRKDSRLMDLTFAIDSLLQRNDKAFKRRLYIKTYFVTPLAEDSGLIEWVDGMRPLRDILTAEHSSRGTAINWKF
IKENLENKGGIKDLVQGLRRIIQMYPSVLRYWFLEVFPEPSAWLEGRGRYGRSLAVMSMVGYILGVGDRHGENILFDVNT
GGIMHVDFDCLFDKGKDLEMPELVPFRMTHNMVDALGVFGCEGIFRKSCEVTLELIRVHEGMVMTMLDVFFHDPILDWSK
KRRQTKKKHIKGFGAARSPEEALWSIQNRIRGKLQEEVMPLKVPGQVSYLIAEATDEQNLAQMYIGWMAYF

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0004674 protein serine/threonine kinase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0016301 kinase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

MIA_00996_1

Protein function

Protein alignments

Mitochondrial localization by mitoprotII

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

Protein sequence

GO term prediction

Biological Process

Molecular Function

Cellular Component