MCA_00799_1

Protein

Length

2,390 amino acids

Gene name: MEC1

Description: Serine/threonine-protein kinase Mec1; genome integrity checkpoint protein and PI kinase superfamily member

Browser: contigA:2486754-2494125+

RNA-seq: read pairs 446, FPKM 2.3, percentile rank 12.4% (100% = highest expression)

Protein function

Annotation:		MEC1	Serine/threonine-protein kinase Mec1; genome integrity checkpoint protein and PI kinase superfamily member
KEGG:	K06640	ATR	serine/threonine-protein kinase ATR [EC:2.7.11.1]
EGGNOG:	0PGIW	MEC1	Serine threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence ST -Q. Recruited to DNA lesions in order to initiate the DNA repair by homologous recombination. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Required for cell growth and meiotic recombination (By similarity)
SGD closest match:	S000000340	MEC1	Serine/threonine-protein kinase MEC1
CGD closest match:	CAL0000200852	MEC1	Serine/threonine-protein kinase MEC1

Protein alignments

	%id	Aln length	E-value
MIA_00996_1	47.03%	2390	0.0	MIA_00996_1
A0A0J9X9H5_GEOCN	36.03%	2445	0.0	Similar to Saccharomyces cerevisiae YBR136W MEC1 Genome integrity checkpoint protein and PI kinase superfamily member OS=Geotrichum candidum GN=BN980_GECA05s01946g PE=3 SV=1
UniRef50_A0A0J9X9H5	36.03%	2445	0.0	Similar to Saccharomyces cerevisiae YBR136W MEC1 Genome integrity checkpoint protein and PI kinase superfamily member n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X9H5_GEOCN
A0A060TBG6_BLAAD	36.56%	2079	0.0	ARAD1D35068p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D35068g PE=3 SV=1
A0A1E3PHR0_9ASCO	33.26%	1924	0.0	Uncharacterized protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_4642 PE=3 SV=1
A0A1E4TKB1_9ASCO	30.73%	1943	0.0	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_23151 PE=3 SV=1
A0A161HFJ3_9ASCO	34.79%	1512	0.0	Protein kinase MEC1 OS=Sugiyamaella lignohabitans GN=MEC1 PE=4 SV=1
ATR_YEAST	28.51%	1940	0.0	Serine/threonine-protein kinase MEC1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MEC1 PE=1 SV=1
ATR_CANAL	27.32%	1936	0.0	Serine/threonine-protein kinase MEC1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MEC1 PE=3 SV=2
Q6C0Z0_YARLI	28.36%	1442	1e-147	YALI0F20636p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F20636g PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0025

Protein family membership

None predicted.

Domains and repeats

Domain
17 - 1,125
Armadillo-type fold (IPR016024)
Armadillo-like helical (IPR011989)
1,337 - 1,914
Tetratricopeptide-like helical domain (IPR011990)
2,358 - 2,390
FATC domain (IPR003152)
Domain
807 - 913
UME domain (IPR012993)
1,336 - 1,926
PIK-related kinase (IPR014009)
PIK-related kinase, FAT (IPR003151)
2,044 - 2,390
Protein kinase-like domain (IPR011009)
Phosphatidylinositol 3-/4-kinase, catalytic domain (IPR000403)

1 500 1000 1500 2000 2390

Detailed signature matches

IPR016024

Armadillo-type fold
1. SSF48371 (ARM repeat)
  
  812 - 1,125
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  523 - 717
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
IPR011989

Armadillo-like helical
1. G3DSA:1.25.10.10
  
  17 - 1,115
  
  GENE3D
  G3DSA:1.25.10.10 (G3DSA:1.25.10.10)
IPR012993

UME domain
1. PF08064 (UME)
  
  810 - 911
  
  Pfam
  PF08064 (UME)
2. SM00802 (UME_cls)
  
  807 - 913
  
  SMART
  SM00802 (UME_cls)
IPR014009

PIK-related kinase
1. PS51189 (FAT)
  
  1,336 - 1,926
  
  PROSITE profiles
  PS51189 (FAT)
IPR011990

Tetratricopeptide-like helical domain
1. G3DSA:1.25.40.10
  
  1,337 - 1,914
  
  GENE3D
  G3DSA:1.25.40.10 (G3DSA:1.25.40.10)
IPR003151

PIK-related kinase, FAT
1. PF02259 (FAT)
  
  1,476 - 1,824
  
  Pfam
  PF02259 (FAT)
IPR011009

Protein kinase-like domain
1. SSF56112 (Protein k...)
  
  2,044 - 2,155
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
  
  2,182 - 2,353
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR000403

Phosphatidylinositol 3-/4-kinase, catalytic domain
1. PS50290 (PI3_4_KINA...)
  
  2,078 - 2,390
  
  PROSITE profiles
  PS50290 (PI3_4_KINASE_3)
2. SM00146 (pi3k_hr1_6)
  
  2,079 - 2,371
  
  SMART
  SM00146 (pi3k_hr1_6)
3. PF00454 (PI3_PI4_ki...)
  
  2,078 - 2,317
  
  Pfam
  PF00454 (PI3_PI4_kinase)
4. G3DSA:1.10.10...
  
  2,166 - 2,357
  
  GENE3D
  G3DSA:1.10.1070.11 (G3DSA:1.10.1070.11)
IPR003152

FATC domain
1. SM01343 (FATC_2)
  
  2,358 - 2,390
  
  SMART
  SM01343 (FATC_2)
2. PF02260 (FATC)
  
  2,359 - 2,390
  
  Pfam
  PF02260 (FATC)
3. PS51190 (FATC)
  
  2,358 - 2,390
  
  PROSITE profiles
  PS51190 (FATC)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

212 - 621

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:3.30.10...

1,934 - 2,137

GENE3D
G3DSA:3.30.1010.10 (G3DSA:3.30.1010.10)
NON_CYTOPLASM... (N...)

1 - 185

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

641 - 2,390

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

189 - 211

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

622 - 640

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

186 - 211

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
cd00892 (PIKKc_ATR)

2,049 - 2,318

CDD
cd00892 (PIKKc_ATR)

Residue annotation

ATP binding site c...

2,059M

ATP binding site
2,059M, 2,061S, 2,062L, 2,063K, 2,065P, 2,081L, 2,083K, 2,086D, 2,121Y, 2,133I, 2,134E, 2,135W, 2,136V, 2,141V, 2,231N, 2,233L, 2,244V, 2,245D
CDD
cd00892 (PIKKc_ATR)

2,061S

ATP binding site
2,059M, 2,061S, 2,062L, 2,063K, 2,065P, 2,081L, 2,083K, 2,086D, 2,121Y, 2,133I, 2,134E, 2,135W, 2,136V, 2,141V, 2,231N, 2,233L, 2,244V, 2,245D
CDD
cd00892 (PIKKc_ATR)

2,062L

ATP binding site
2,059M, 2,061S, 2,062L, 2,063K, 2,065P, 2,081L, 2,083K, 2,086D, 2,121Y, 2,133I, 2,134E, 2,135W, 2,136V, 2,141V, 2,231N, 2,233L, 2,244V, 2,245D
CDD
cd00892 (PIKKc_ATR)

2,063K

ATP binding site
2,059M, 2,061S, 2,062L, 2,063K, 2,065P, 2,081L, 2,083K, 2,086D, 2,121Y, 2,133I, 2,134E, 2,135W, 2,136V, 2,141V, 2,231N, 2,233L, 2,244V, 2,245D
CDD
cd00892 (PIKKc_ATR)

2,065P

ATP binding site
2,059M, 2,061S, 2,062L, 2,063K, 2,065P, 2,081L, 2,083K, 2,086D, 2,121Y, 2,133I, 2,134E, 2,135W, 2,136V, 2,141V, 2,231N, 2,233L, 2,244V, 2,245D
CDD
cd00892 (PIKKc_ATR)

2,081L

ATP binding site
2,059M, 2,061S, 2,062L, 2,063K, 2,065P, 2,081L, 2,083K, 2,086D, 2,121Y, 2,133I, 2,134E, 2,135W, 2,136V, 2,141V, 2,231N, 2,233L, 2,244V, 2,245D
CDD
cd00892 (PIKKc_ATR)

2,083K

ATP binding site
2,059M, 2,061S, 2,062L, 2,063K, 2,065P, 2,081L, 2,083K, 2,086D, 2,121Y, 2,133I, 2,134E, 2,135W, 2,136V, 2,141V, 2,231N, 2,233L, 2,244V, 2,245D
CDD
cd00892 (PIKKc_ATR)

2,086D

ATP binding site
2,059M, 2,061S, 2,062L, 2,063K, 2,065P, 2,081L, 2,083K, 2,086D, 2,121Y, 2,133I, 2,134E, 2,135W, 2,136V, 2,141V, 2,231N, 2,233L, 2,244V, 2,245D
CDD
cd00892 (PIKKc_ATR)

2,121Y

ATP binding site
2,059M, 2,061S, 2,062L, 2,063K, 2,065P, 2,081L, 2,083K, 2,086D, 2,121Y, 2,133I, 2,134E, 2,135W, 2,136V, 2,141V, 2,231N, 2,233L, 2,244V, 2,245D
CDD
cd00892 (PIKKc_ATR)

2,133I

ATP binding site
2,059M, 2,061S, 2,062L, 2,063K, 2,065P, 2,081L, 2,083K, 2,086D, 2,121Y, 2,133I, 2,134E, 2,135W, 2,136V, 2,141V, 2,231N, 2,233L, 2,244V, 2,245D
CDD
cd00892 (PIKKc_ATR)

2,134E

ATP binding site
2,059M, 2,061S, 2,062L, 2,063K, 2,065P, 2,081L, 2,083K, 2,086D, 2,121Y, 2,133I, 2,134E, 2,135W, 2,136V, 2,141V, 2,231N, 2,233L, 2,244V, 2,245D
CDD
cd00892 (PIKKc_ATR)

2,135W

ATP binding site
2,059M, 2,061S, 2,062L, 2,063K, 2,065P, 2,081L, 2,083K, 2,086D, 2,121Y, 2,133I, 2,134E, 2,135W, 2,136V, 2,141V, 2,231N, 2,233L, 2,244V, 2,245D
CDD
cd00892 (PIKKc_ATR)

2,136V

ATP binding site
2,059M, 2,061S, 2,062L, 2,063K, 2,065P, 2,081L, 2,083K, 2,086D, 2,121Y, 2,133I, 2,134E, 2,135W, 2,136V, 2,141V, 2,231N, 2,233L, 2,244V, 2,245D
CDD
cd00892 (PIKKc_ATR)

2,141V

ATP binding site
2,059M, 2,061S, 2,062L, 2,063K, 2,065P, 2,081L, 2,083K, 2,086D, 2,121Y, 2,133I, 2,134E, 2,135W, 2,136V, 2,141V, 2,231N, 2,233L, 2,244V, 2,245D
CDD
cd00892 (PIKKc_ATR)

2,231N

ATP binding site
2,059M, 2,061S, 2,062L, 2,063K, 2,065P, 2,081L, 2,083K, 2,086D, 2,121Y, 2,133I, 2,134E, 2,135W, 2,136V, 2,141V, 2,231N, 2,233L, 2,244V, 2,245D
CDD
cd00892 (PIKKc_ATR)

2,233L

ATP binding site
2,059M, 2,061S, 2,062L, 2,063K, 2,065P, 2,081L, 2,083K, 2,086D, 2,121Y, 2,133I, 2,134E, 2,135W, 2,136V, 2,141V, 2,231N, 2,233L, 2,244V, 2,245D
CDD
cd00892 (PIKKc_ATR)

2,244V

ATP binding site
2,059M, 2,061S, 2,062L, 2,063K, 2,065P, 2,081L, 2,083K, 2,086D, 2,121Y, 2,133I, 2,134E, 2,135W, 2,136V, 2,141V, 2,231N, 2,233L, 2,244V, 2,245D
CDD
cd00892 (PIKKc_ATR)

2,245D

ATP binding site
2,059M, 2,061S, 2,062L, 2,063K, 2,065P, 2,081L, 2,083K, 2,086D, 2,121Y, 2,133I, 2,134E, 2,135W, 2,136V, 2,141V, 2,231N, 2,233L, 2,244V, 2,245D
CDD
cd00892 (PIKKc_ATR)
catalytic loop cd0...

2,223G

catalytic loop
2,223G, 2,224L, 2,225G, 2,226D, 2,227R, 2,228H, 2,229G, 2,230E, 2,231N
CDD
cd00892 (PIKKc_ATR)

2,224L

catalytic loop
2,223G, 2,224L, 2,225G, 2,226D, 2,227R, 2,228H, 2,229G, 2,230E, 2,231N
CDD
cd00892 (PIKKc_ATR)

2,225G

catalytic loop
2,223G, 2,224L, 2,225G, 2,226D, 2,227R, 2,228H, 2,229G, 2,230E, 2,231N
CDD
cd00892 (PIKKc_ATR)

2,226D

catalytic loop
2,223G, 2,224L, 2,225G, 2,226D, 2,227R, 2,228H, 2,229G, 2,230E, 2,231N
CDD
cd00892 (PIKKc_ATR)

2,227R

catalytic loop
2,223G, 2,224L, 2,225G, 2,226D, 2,227R, 2,228H, 2,229G, 2,230E, 2,231N
CDD
cd00892 (PIKKc_ATR)

2,228H

catalytic loop
2,223G, 2,224L, 2,225G, 2,226D, 2,227R, 2,228H, 2,229G, 2,230E, 2,231N
CDD
cd00892 (PIKKc_ATR)

2,229G

catalytic loop
2,223G, 2,224L, 2,225G, 2,226D, 2,227R, 2,228H, 2,229G, 2,230E, 2,231N
CDD
cd00892 (PIKKc_ATR)

2,230E

catalytic loop
2,223G, 2,224L, 2,225G, 2,226D, 2,227R, 2,228H, 2,229G, 2,230E, 2,231N
CDD
cd00892 (PIKKc_ATR)

2,231N

catalytic loop
2,223G, 2,224L, 2,225G, 2,226D, 2,227R, 2,228H, 2,229G, 2,230E, 2,231N
CDD
cd00892 (PIKKc_ATR)
activation loop (A...

2,245D

activation loop (A-loop)
2,245D, 2,246F, 2,247D, 2,248C, 2,249L, 2,250F, 2,251D, 2,252K, 2,253G, 2,254K, 2,255E, 2,256M, 2,257E, 2,258A, 2,259P, 2,260E, 2,261L, 2,262V, 2,263P, 2,264F, 2,265R, 2,266L, 2,267T
CDD
cd00892 (PIKKc_ATR)

2,246F

activation loop (A-loop)
2,245D, 2,246F, 2,247D, 2,248C, 2,249L, 2,250F, 2,251D, 2,252K, 2,253G, 2,254K, 2,255E, 2,256M, 2,257E, 2,258A, 2,259P, 2,260E, 2,261L, 2,262V, 2,263P, 2,264F, 2,265R, 2,266L, 2,267T
CDD
cd00892 (PIKKc_ATR)

2,247D

activation loop (A-loop)
2,245D, 2,246F, 2,247D, 2,248C, 2,249L, 2,250F, 2,251D, 2,252K, 2,253G, 2,254K, 2,255E, 2,256M, 2,257E, 2,258A, 2,259P, 2,260E, 2,261L, 2,262V, 2,263P, 2,264F, 2,265R, 2,266L, 2,267T
CDD
cd00892 (PIKKc_ATR)

2,248C

activation loop (A-loop)
2,245D, 2,246F, 2,247D, 2,248C, 2,249L, 2,250F, 2,251D, 2,252K, 2,253G, 2,254K, 2,255E, 2,256M, 2,257E, 2,258A, 2,259P, 2,260E, 2,261L, 2,262V, 2,263P, 2,264F, 2,265R, 2,266L, 2,267T
CDD
cd00892 (PIKKc_ATR)

2,249L

activation loop (A-loop)
2,245D, 2,246F, 2,247D, 2,248C, 2,249L, 2,250F, 2,251D, 2,252K, 2,253G, 2,254K, 2,255E, 2,256M, 2,257E, 2,258A, 2,259P, 2,260E, 2,261L, 2,262V, 2,263P, 2,264F, 2,265R, 2,266L, 2,267T
CDD
cd00892 (PIKKc_ATR)

2,250F

activation loop (A-loop)
2,245D, 2,246F, 2,247D, 2,248C, 2,249L, 2,250F, 2,251D, 2,252K, 2,253G, 2,254K, 2,255E, 2,256M, 2,257E, 2,258A, 2,259P, 2,260E, 2,261L, 2,262V, 2,263P, 2,264F, 2,265R, 2,266L, 2,267T
CDD
cd00892 (PIKKc_ATR)

2,251D

activation loop (A-loop)
2,245D, 2,246F, 2,247D, 2,248C, 2,249L, 2,250F, 2,251D, 2,252K, 2,253G, 2,254K, 2,255E, 2,256M, 2,257E, 2,258A, 2,259P, 2,260E, 2,261L, 2,262V, 2,263P, 2,264F, 2,265R, 2,266L, 2,267T
CDD
cd00892 (PIKKc_ATR)

2,252K

activation loop (A-loop)
2,245D, 2,246F, 2,247D, 2,248C, 2,249L, 2,250F, 2,251D, 2,252K, 2,253G, 2,254K, 2,255E, 2,256M, 2,257E, 2,258A, 2,259P, 2,260E, 2,261L, 2,262V, 2,263P, 2,264F, 2,265R, 2,266L, 2,267T
CDD
cd00892 (PIKKc_ATR)

2,253G

activation loop (A-loop)
2,245D, 2,246F, 2,247D, 2,248C, 2,249L, 2,250F, 2,251D, 2,252K, 2,253G, 2,254K, 2,255E, 2,256M, 2,257E, 2,258A, 2,259P, 2,260E, 2,261L, 2,262V, 2,263P, 2,264F, 2,265R, 2,266L, 2,267T
CDD
cd00892 (PIKKc_ATR)

2,254K

activation loop (A-loop)
2,245D, 2,246F, 2,247D, 2,248C, 2,249L, 2,250F, 2,251D, 2,252K, 2,253G, 2,254K, 2,255E, 2,256M, 2,257E, 2,258A, 2,259P, 2,260E, 2,261L, 2,262V, 2,263P, 2,264F, 2,265R, 2,266L, 2,267T
CDD
cd00892 (PIKKc_ATR)

2,255E

activation loop (A-loop)
2,245D, 2,246F, 2,247D, 2,248C, 2,249L, 2,250F, 2,251D, 2,252K, 2,253G, 2,254K, 2,255E, 2,256M, 2,257E, 2,258A, 2,259P, 2,260E, 2,261L, 2,262V, 2,263P, 2,264F, 2,265R, 2,266L, 2,267T
CDD
cd00892 (PIKKc_ATR)

2,256M

activation loop (A-loop)
2,245D, 2,246F, 2,247D, 2,248C, 2,249L, 2,250F, 2,251D, 2,252K, 2,253G, 2,254K, 2,255E, 2,256M, 2,257E, 2,258A, 2,259P, 2,260E, 2,261L, 2,262V, 2,263P, 2,264F, 2,265R, 2,266L, 2,267T
CDD
cd00892 (PIKKc_ATR)

2,257E

activation loop (A-loop)
2,245D, 2,246F, 2,247D, 2,248C, 2,249L, 2,250F, 2,251D, 2,252K, 2,253G, 2,254K, 2,255E, 2,256M, 2,257E, 2,258A, 2,259P, 2,260E, 2,261L, 2,262V, 2,263P, 2,264F, 2,265R, 2,266L, 2,267T
CDD
cd00892 (PIKKc_ATR)

2,258A

activation loop (A-loop)
2,245D, 2,246F, 2,247D, 2,248C, 2,249L, 2,250F, 2,251D, 2,252K, 2,253G, 2,254K, 2,255E, 2,256M, 2,257E, 2,258A, 2,259P, 2,260E, 2,261L, 2,262V, 2,263P, 2,264F, 2,265R, 2,266L, 2,267T
CDD
cd00892 (PIKKc_ATR)

2,259P

activation loop (A-loop)
2,245D, 2,246F, 2,247D, 2,248C, 2,249L, 2,250F, 2,251D, 2,252K, 2,253G, 2,254K, 2,255E, 2,256M, 2,257E, 2,258A, 2,259P, 2,260E, 2,261L, 2,262V, 2,263P, 2,264F, 2,265R, 2,266L, 2,267T
CDD
cd00892 (PIKKc_ATR)

2,260E

activation loop (A-loop)
2,245D, 2,246F, 2,247D, 2,248C, 2,249L, 2,250F, 2,251D, 2,252K, 2,253G, 2,254K, 2,255E, 2,256M, 2,257E, 2,258A, 2,259P, 2,260E, 2,261L, 2,262V, 2,263P, 2,264F, 2,265R, 2,266L, 2,267T
CDD
cd00892 (PIKKc_ATR)

2,261L

activation loop (A-loop)
2,245D, 2,246F, 2,247D, 2,248C, 2,249L, 2,250F, 2,251D, 2,252K, 2,253G, 2,254K, 2,255E, 2,256M, 2,257E, 2,258A, 2,259P, 2,260E, 2,261L, 2,262V, 2,263P, 2,264F, 2,265R, 2,266L, 2,267T
CDD
cd00892 (PIKKc_ATR)

2,262V

activation loop (A-loop)
2,245D, 2,246F, 2,247D, 2,248C, 2,249L, 2,250F, 2,251D, 2,252K, 2,253G, 2,254K, 2,255E, 2,256M, 2,257E, 2,258A, 2,259P, 2,260E, 2,261L, 2,262V, 2,263P, 2,264F, 2,265R, 2,266L, 2,267T
CDD
cd00892 (PIKKc_ATR)

2,263P

activation loop (A-loop)
2,245D, 2,246F, 2,247D, 2,248C, 2,249L, 2,250F, 2,251D, 2,252K, 2,253G, 2,254K, 2,255E, 2,256M, 2,257E, 2,258A, 2,259P, 2,260E, 2,261L, 2,262V, 2,263P, 2,264F, 2,265R, 2,266L, 2,267T
CDD
cd00892 (PIKKc_ATR)

2,264F

activation loop (A-loop)
2,245D, 2,246F, 2,247D, 2,248C, 2,249L, 2,250F, 2,251D, 2,252K, 2,253G, 2,254K, 2,255E, 2,256M, 2,257E, 2,258A, 2,259P, 2,260E, 2,261L, 2,262V, 2,263P, 2,264F, 2,265R, 2,266L, 2,267T
CDD
cd00892 (PIKKc_ATR)

2,265R

activation loop (A-loop)
2,245D, 2,246F, 2,247D, 2,248C, 2,249L, 2,250F, 2,251D, 2,252K, 2,253G, 2,254K, 2,255E, 2,256M, 2,257E, 2,258A, 2,259P, 2,260E, 2,261L, 2,262V, 2,263P, 2,264F, 2,265R, 2,266L, 2,267T
CDD
cd00892 (PIKKc_ATR)

2,266L

activation loop (A-loop)
2,245D, 2,246F, 2,247D, 2,248C, 2,249L, 2,250F, 2,251D, 2,252K, 2,253G, 2,254K, 2,255E, 2,256M, 2,257E, 2,258A, 2,259P, 2,260E, 2,261L, 2,262V, 2,263P, 2,264F, 2,265R, 2,266L, 2,267T
CDD
cd00892 (PIKKc_ATR)

2,267T

activation loop (A-loop)
2,245D, 2,246F, 2,247D, 2,248C, 2,249L, 2,250F, 2,251D, 2,252K, 2,253G, 2,254K, 2,255E, 2,256M, 2,257E, 2,258A, 2,259P, 2,260E, 2,261L, 2,262V, 2,263P, 2,264F, 2,265R, 2,266L, 2,267T
CDD
cd00892 (PIKKc_ATR)

Protein sequence

>MCA_00799_1
MNLESKLEGDDNNSLDNSLNEFINTLNETKPEELLLESDRCTQFLNFIHEKSLSKLLKVDPSSFSQEHVAQAVSSIKALK
TLVIYKPSPFLELDGDHYMYEKIVPTILLLSKFDSFEISTHVGFFLKSTFSSITKDSVLYASNARLCIYLLDICSSFLQS
LNQENLPLTNSISKAFISISQSQYHSLNICFIIIQSLLTSVISVPGFFLILKQNFFPKIYKTVSEILSQLKKTTRSFDLD
YLQIDNLHLKFSNILSLSLESFSRNAGWCNLSIDWLLLIQTLASFRELDTQLDVAAAALALDLISIIFDGQAGGIAKVEH
VTTTPGDSQASKTIDLVIEALSSIVDPAEFSMLFDLIEYTDPFLILKANSLKESLNKNHFTLSCSFPKYQQNTLQFSKLF
EELDFLSMPIFSADDLKFFIEKKFDLLSLGEKISLVNMVGLSACYTVGTLDMGSFKCKTCDFGVFMPSDSKIQSPVYTQI
FMLILGSDRFTDYKDLRLATLKALRRALNGIDIITIGSDLDEWVIKSLQSTNRDIRIAASMIPPLYSDREYIIKAILRLD
LINKDYLVETTILAWAQMAKFSEGQDLNILLRELVKIFSYSNDFYVSQSMYHLRSIASHKGVNLWNLFAPFWSTISIYIV
KNKNTNPNILTRFCELVAVSKEIFYARTYEYTVPYIILGGDKPLLEEIANALEWTVEKLILNTISKTFAIFLCKKPNQIS
TVFQKLVKILPNFAQVEISQIINPSRIEIAYEILKIHDPNDLEKSDRISRVFANLYELLRKKSKKRKKSAIDGEDSGKEL
SPSMESIELFFEDNILGIISYFSKSIRDSTGKVAHLEKLQGLRGLIKLIECAGSAFSKALPQISVILQSALEDQVLQLEA
LKVWAHMLKFMSTEELETVTDLTFSVIIQNWDFFTSEAQTEGHKLLRYLIFEKREELQNIIKKRSIPYTYGMLPDLGDIY
AEILTMIPPQPEEISPLLPLLVRSSNENVYVVRQTILEINNFLINNQGCIKSAMDNSIQRAHYIEPLYKMLLQTSYQFHN
SNTDIPYICAQCLGLLGAADPTKVRIANEISDIVVVHNFYDAKESIYFVSQFMEHFLVKAFVSSTDPNCQAYLAYGIQEY
LKFCGLYLGGPTTRSRQESIWDCFSLSSQVIMQPMRNSRYTLTIPEGDEKVHYPLFNPNMDHFQWLTRFVLDLLSHTDDE
SNPNATRVFKICRKIIINQDASLYNFILPYVALTIVLGNNENYRENIVNEMLIILNTDLEDSDNTQDNLKRCYSSVFSII
DYFNKWMRKRQNYFAELNKAKSRTKTVVPSSAKRDPKNDRPIAIVQEIIGRISADLMAKRSYQCKSYPRAIMYWEQHLKK
PLEQKEREGIYSKFMEIYSNINDPDSIDGVARSFQHISIPRKIIQLESTGRWDDALECYESLVHSSNNDWQWDSEYGYNM
LQCMKNGGNYEGLLTLLDSMEHSGKEIPEQLLGIGVETSWLAGDFDKMNSLLAQIPSESFINKSFEVNIGRAMNSLRNHD
FEDFKNKIELARKGVSDSLASTFTSTMHQCHRALVQLHGLADLESIGELDISGSSQFKHRDVSLKLNQRLDVVGSDYTSK
LYLLALRRSAVMSSHLSYAEQESQITWIYSSRFARKQKHLKLALSASLNSLPNTSLSRYEPYIEYAKLLWAQEEYHEAII
TLDNIVPDGLLRYLEEKYSSVKKSSANQSRHDENNDDSDRSIVDGYIAKAALLQTKWLDQSGEGKSSDIMMRYSLIARVY
SSWEKGYYSMAKYYNRIYDSQLAQSIETRNEEFFNGEYIYNMVRFYCMSLPFSVKHVYETLPKLFSLWLDFAEKIKFLGD
NIPFSEEWKREILKERITNLKKINEFLLKYIPRIPCFILYLSMPQLLSRILIRNSEVIQVLKKIIVEIIKCYPRQSLWYL
FGISNSKPKEDIIATISGVKANFSLDNSTDTSQRLKPLVDSAIQLTSELNKLASADAKAGKSKLQDFKFNKKVLPCGLVV
PVQLCMRVTMPSNGSSSSITSVPTPSAGMPHTSPLNSHIAFPRHSIVTIFQLEESVDTMPSLKKPKRIVMIGSNGVRYKI
LCKADDDVRKDSRFMDVTGAIDYLLQQNEASFKRQLFIRSYFVTPLGESSGLIEWVDGMSVLRQIIEGQYNNLGIPLNWT
VIRNLFKPVGQEMIAFKECLKMYPSVLQDWFLENFPEPSAWLDGRNTFAKSLAVMSMVGFIFGLGDRHGENILLDVNTGA
IMHVDFDCLFDKGKEMEAPELVPFRLTHNLVSALGVFGYEGIFRKSSEVTLQLVRDYEDMIMTMLDVFLHDPINDWSRRK
RTSKNKTRVKGFGAARSPEEALSIIRNKIRGSLMEEVMPMKVPGQVSYLIAEATDEQNLAYMYIGWMAYW

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0004674 protein serine/threonine kinase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0016301 kinase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

MCA_00799_1

Protein function

Protein alignments

Mitochondrial localization by mitoprotII

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

Protein sequence

GO term prediction

Biological Process

Molecular Function

Cellular Component