Protein

MIA_00982_1

Length
429 amino acids


Browser: contig01:2802709-2803999+

Protein function

EGGNOG:0PFCHPlays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first
SGD closest match:S000005164ADE12Adenylosuccinate synthetase
CGD closest match:CAL0000175348ADE12Adenylosuccinate synthetase

Protein alignments

%idAln lengthE-value
MCA_01942_185.21%4260.0MCA_01942_1
A0A0J9XC51_GEOCN80.28%4260.0Adenylosuccinate synthetase OS=Geotrichum candidum GN=BN980_GECA09s00725g PE=3 SV=1
A0A1E3PIU7_9ASCO75.71%4240.0Adenylosuccinate synthetase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_51462 PE=3 SV=1
PURA_YARLI71.70%4240.0Adenylosuccinate synthetase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0E28963g PE=3 SV=1
A0A060SWD4_BLAAD71.93%4240.0Adenylosuccinate synthetase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A03410g PE=3 SV=1
A0A1E4TG85_9ASCO69.41%4250.0Adenylosuccinate synthetase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2418 PE=3 SV=1
PURA_CANAL70.28%4240.0Adenylosuccinate synthetase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ADE12 PE=3 SV=1
A0A161HJQ4_9ASCO75.00%3720.0Adenylosuccinate synthetase OS=Sugiyamaella lignohabitans GN=ADE12 PE=3 SV=1
PURA_YEAST66.82%4280.0Adenylosuccinate synthetase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ADE12 PE=1 SV=3
UniRef50_Q4P7R265.81%4270.0Adenylosuccinate synthetase n=39 Tax=Dikarya TaxID=451864 RepID=PURA_USTMA

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0075

Protein family membership

Domains and repeats

1 50 100 150 200 250 300 350 400 429

Detailed signature matches

    1. PF00709 (Adenylsucc...)
    2. MF_00011 (Adenylosu...)
    3. SM00788 (adenylsucc...)
    4. cd03108 (AdSS)
    1. SSF52540 (P-loop co...)
    1. PS01266 (ADENYLOSUC...)
    1. PS00513 (ADENYLOSUC...)
Unintegrated signatures no IPR
Unintegrated signatures

Residue annotation

  1. GDP-binding site c...
  2. ACT binding site c...
  3. IMP binding site c...

Protein sequence

>MIA_00982_1
MANVVLGAQWGDEGKGKLVDLLCDDIDVCARCQGGNNAGHTIVVDGKTFDFHMLPSGLINPNCVNIVGTGVVVHIPSFFQ
ELENIQKKGLDTTGRLFLSSRAHLVFDFHQIVDGLREAELSSSNKAIGTTRKGIGPAYSTKASRSGLRVHHLISQEEGAW
EEFETKFRKLVAGRHKRYGFFEYDVDAEVARYKEYADKIRPFVVDNIPFINKAFNENKKVLVEGANALMLDLDFGTYPYV
TSSNTAIGGVCTGLGIPPHKIKEIYGVVKAYTTRVGAGPFPTEQLNEIGEHLQDVGHEYGVTTGRKRRCGWLDLVVLKYS
TLINGYTHLNITKLDILDDLLEIKVAVAYRHNGKLLESMPEDLNILEKVEVVYETFPGWKAHTSKARTFDELPKEAQNYL
KFIEDFIKVPIRWIGVGPARDQMIVVEQS

GO term prediction

Biological Process

GO:0006164 purine nucleotide biosynthetic process

Molecular Function

GO:0004019 adenylosuccinate synthase activity
GO:0005525 GTP binding

Cellular Component

None predicted.