Protein

MCA_01942_1

Length
426 amino acids

Browser: contigA:5933501-5934782+

RNA-seq: read pairs 13877, FPKM 401.6, percentile rank 93.5% (100% = highest expression)

Protein function

KEGG:K01939purA adenylosuccinate synthase [EC:6.3.4.4]
EGGNOG:0PFCHPlays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first
SGD closest match:S000005164ADE12Adenylosuccinate synthetase
CGD closest match:CAL0000175348ADE12Adenylosuccinate synthetase

Protein alignments

%idAln lengthE-value
MIA_00982_185.21%4260.0MIA_00982_1
A0A0J9XC51_GEOCN80.99%4260.0Adenylosuccinate synthetase OS=Geotrichum candidum GN=BN980_GECA09s00725g PE=3 SV=1
A0A1E3PIU7_9ASCO74.35%4250.0Adenylosuccinate synthetase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_51462 PE=3 SV=1
A0A060SWD4_BLAAD72.64%4240.0Adenylosuccinate synthetase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A03410g PE=3 SV=1
PURA_YARLI71.93%4240.0Adenylosuccinate synthetase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0E28963g PE=3 SV=1
PURA_CANAL72.17%4240.0Adenylosuccinate synthetase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ADE12 PE=3 SV=1
A0A1E4TG85_9ASCO70.35%4250.0Adenylosuccinate synthetase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2418 PE=3 SV=1
PURA_YEAST69.16%4280.0Adenylosuccinate synthetase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ADE12 PE=1 SV=3
A0A161HJQ4_9ASCO77.21%3730.0Adenylosuccinate synthetase OS=Sugiyamaella lignohabitans GN=ADE12 PE=3 SV=1
UniRef50_Q4P7R265.81%4270.0Adenylosuccinate synthetase n=39 Tax=Dikarya TaxID=451864 RepID=PURA_USTMA

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0078

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 426

Detailed signature matches

  1. Family IPR001114
    Adenylosuccinate synthetase
    1. PF00709 (Adenylsucc...)
    2. MF_00011 (Adenylosu...)
    3. TIGR00184
    4. SM00788 (adenylsucc...)
    5. cd03108 (AdSS)
  2. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  3. SITE IPR018220
    Adenylosuccinate synthase, GTP-binding site
    1. PS01266 (ADENYLOSUC...)
  4. SITE IPR033128
    Adenylosuccinate synthase, active site
    1. PS00513 (ADENYLOSUC...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.44...
  2. G3DSA:3.90.17...

Residue annotation

  1. GDP-binding site c...
  2. ACT binding site c...
  3. IMP binding site c...

Protein sequence

>MCA_01942_1
MANVVLGAQWGDEGKGKLVDLLCDDVEVCARCQGGNNAGHTIVVNGVTFDFHMLPSGLINPNCVNLVGSGVVIHVPSFFQ
ELENLQKKGLDTTDRLFVSSRAQLVFDFHQIVDGLKEAELSFSNKAIGTTRKGIGPAYSTKASRSGLRVHHLVSQEEGAW
EEFETKFKKLLDSRIKRYGFFEYDVEGELKKYKEYAEKLRPFVVDNISFLHKYFDAKKNVLIEGANALMLDLDFGTYPYV
TSSNTSIGGVCTGLGIPPSKIKEVYGVVKAYTTRVGAGPFPTEQLNEIGEHLQNVGHEYGVTTGRKRRCGWLDLVVVKYS
TLINGYTHLNITKLDILDDLIEIKVAVGYEYKGKLLESFPEDLGILEKVEVKYKTFPGWKRHISDIRKFEDLPIEAQNYL
KFIEEFLNVPVKWIGVGPARDQMIVV

GO term prediction

Biological Process

GO:0006164 purine nucleotide biosynthetic process

Molecular Function

GO:0004019 adenylosuccinate synthase activity
GO:0005525 GTP binding

Cellular Component

None predicted.