MIA_00928_1

Protein

Length

1,261 amino acids

Protein function

EGGNOG:	0PJNC	FG05203.1	Pumilio-family RNA binding repeat
SGD closest match:	S000003936	PUF3	mRNA-binding protein PUF3
CGD closest match:	CAL0000187550	PUF3	mRNA-binding protein

Protein alignments

	%id	Aln length	E-value
MCA_01140_1	73.090%	301	2.39e-153	MCA_01140_1
UniRef50_M7NRK5	60.350%	343	1.02e-139	Uncharacterized protein n=4 Tax=Pneumocystis TaxID=4753 RepID=M7NRK5_PNEMU
A0A167CDW0_9ASCO	62.543%	291	1.94e-123	mRNA-binding protein PUF3 OS=Sugiyamaella lignohabitans GN=PUF3 PE=4 SV=1
A0A0J9X7K4_GEOCN	69.742%	271	1.35e-131	Similar to Saccharomyces cerevisiae YLL013C PUF3 Protein of the mitochondrial outer surface OS=Geotrichum candidum GN=BN980_GECA04s04476g PE=4 SV=1
W0TYP6_YARLI	39.943%	348	2.46e-72	YALI0B03146p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B03146g PE=4 SV=1
A0A1E3PG58_9ASCO	28.000%	400	7.95e-49	ARM repeat-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_43202 PE=4 SV=1
A0A060T1G3_BLAAD	28.173%	323	7.86e-36	ARAD1C20284p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C20284g PE=4 SV=1
A0A1D8PMA5_CANAL	27.869%	305	2.04e-31	mRNA-binding protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PUF3 PE=4 SV=1
PUF3_YEAST	25.000%	312	9.98e-27	mRNA-binding protein PUF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PUF3 PE=1 SV=1
A0A1E4TM35_9ASCO	25.914%	301	1.51e-26	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_20765 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0095

Protein family membership

None predicted.

Domains and repeats

Domain
893 - 1,252
Armadillo-type fold (IPR016024)
Armadillo-like helical (IPR011989)
Pumilio homology domain (IPR033133)
Pumilio, RNA binding domain (IPR033712)
Repeat
920 - 955
Pumilio RNA-binding repeat (IPR001313)
956 - 991
Pumilio RNA-binding repeat (IPR001313)
992 - 1,027
Pumilio RNA-binding repeat (IPR001313)
1,028 - 1,063
Pumilio RNA-binding repeat (IPR001313)
1,068 - 1,107
Pumilio RNA-binding repeat (IPR001313)
1,104 - 1,139
Pumilio RNA-binding repeat (IPR001313)
1,139 - 1,175
Pumilio RNA-binding repeat (IPR001313)
1,184 - 1,219
Pumilio RNA-binding repeat (IPR001313)

1 200 400 600 800 1000 1261

Detailed signature matches

IPR016024

Armadillo-type fold
1. SSF48371 (ARM repeat)
  
  930 - 1,239
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
IPR011989

Armadillo-like helical
1. G3DSA:1.25.10.10
  
  912 - 1,252
  
  GENE3D
  G3DSA:1.25.10.10 (G3DSA:1.25.10.10)
IPR033133

Pumilio homology domain
1. PS50303 (PUM_HD)
  
  893 - 1,245
  
  PROSITE profiles
  PS50303 (PUM_HD)
IPR033712

Pumilio, RNA binding domain
1. cd07920 (Pumilio)
  
  930 - 1,241
  
  CDD
  cd07920 (Pumilio)
IPR001313

Pumilio RNA-binding repeat
1. PS50302 (PUM)
  
  1,028 - 1,063
  
  PROSITE profiles
  PS50302 (PUM)
  
  920 - 955
  
  PROSITE profiles
  PS50302 (PUM)
  
  992 - 1,027
  
  PROSITE profiles
  PS50302 (PUM)
  
  1,184 - 1,219
  
  PROSITE profiles
  PS50302 (PUM)
  
  956 - 991
  
  PROSITE profiles
  PS50302 (PUM)
  
  1,139 - 1,175
  
  PROSITE profiles
  PS50302 (PUM)
  
  1,068 - 1,107
  
  PROSITE profiles
  PS50302 (PUM)
2. PF00806 (PUF)
  
  959 - 987
  
  Pfam
  PF00806 (PUF)
  
  993 - 1,023
  
  Pfam
  PF00806 (PUF)
3. SM00025 (pum_5)
  
  1,028 - 1,063
  
  SMART
  SM00025 (pum_5)
  
  1,068 - 1,103
  
  SMART
  SM00025 (pum_5)
  
  1,104 - 1,139
  
  SMART
  SM00025 (pum_5)
  
  1,140 - 1,175
  
  SMART
  SM00025 (pum_5)
  
  956 - 991
  
  SMART
  SM00025 (pum_5)
  
  992 - 1,027
  
  SMART
  SM00025 (pum_5)
  
  1,184 - 1,219
  
  SMART
  SM00025 (pum_5)

no IPR

Unintegrated signatures

Coil

376 - 403

COILS
Coil (Coil)
mobidb-lite (disord...)

658 - 681

MobiDB Lite
mobidb-lite (disorder_prediction)

136 - 167

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

RNA binding site c...

971N

RNA binding site
971N, 972F, 975Q, 1,007C, 1,008H, 1,011Q, 1,044H, 1,047Q, 1,083S, 1,084L, 1,087Q, 1,116Q, 1,117W, 1,119N, 1,120W, 1,123Q, 1,152Q, 1,153Y, 1,155S, 1,156K, 1,159E, 1,196A, 1,197H, 1,199N, 1,200Y, 1,203Q, 1,233W, 1,236K
CDD
cd07920 (Pumilio)

972F

RNA binding site
971N, 972F, 975Q, 1,007C, 1,008H, 1,011Q, 1,044H, 1,047Q, 1,083S, 1,084L, 1,087Q, 1,116Q, 1,117W, 1,119N, 1,120W, 1,123Q, 1,152Q, 1,153Y, 1,155S, 1,156K, 1,159E, 1,196A, 1,197H, 1,199N, 1,200Y, 1,203Q, 1,233W, 1,236K
CDD
cd07920 (Pumilio)

975Q

RNA binding site
971N, 972F, 975Q, 1,007C, 1,008H, 1,011Q, 1,044H, 1,047Q, 1,083S, 1,084L, 1,087Q, 1,116Q, 1,117W, 1,119N, 1,120W, 1,123Q, 1,152Q, 1,153Y, 1,155S, 1,156K, 1,159E, 1,196A, 1,197H, 1,199N, 1,200Y, 1,203Q, 1,233W, 1,236K
CDD
cd07920 (Pumilio)

1,007C

RNA binding site
971N, 972F, 975Q, 1,007C, 1,008H, 1,011Q, 1,044H, 1,047Q, 1,083S, 1,084L, 1,087Q, 1,116Q, 1,117W, 1,119N, 1,120W, 1,123Q, 1,152Q, 1,153Y, 1,155S, 1,156K, 1,159E, 1,196A, 1,197H, 1,199N, 1,200Y, 1,203Q, 1,233W, 1,236K
CDD
cd07920 (Pumilio)

1,008H

RNA binding site
971N, 972F, 975Q, 1,007C, 1,008H, 1,011Q, 1,044H, 1,047Q, 1,083S, 1,084L, 1,087Q, 1,116Q, 1,117W, 1,119N, 1,120W, 1,123Q, 1,152Q, 1,153Y, 1,155S, 1,156K, 1,159E, 1,196A, 1,197H, 1,199N, 1,200Y, 1,203Q, 1,233W, 1,236K
CDD
cd07920 (Pumilio)

1,011Q

RNA binding site
971N, 972F, 975Q, 1,007C, 1,008H, 1,011Q, 1,044H, 1,047Q, 1,083S, 1,084L, 1,087Q, 1,116Q, 1,117W, 1,119N, 1,120W, 1,123Q, 1,152Q, 1,153Y, 1,155S, 1,156K, 1,159E, 1,196A, 1,197H, 1,199N, 1,200Y, 1,203Q, 1,233W, 1,236K
CDD
cd07920 (Pumilio)

1,044H

RNA binding site
971N, 972F, 975Q, 1,007C, 1,008H, 1,011Q, 1,044H, 1,047Q, 1,083S, 1,084L, 1,087Q, 1,116Q, 1,117W, 1,119N, 1,120W, 1,123Q, 1,152Q, 1,153Y, 1,155S, 1,156K, 1,159E, 1,196A, 1,197H, 1,199N, 1,200Y, 1,203Q, 1,233W, 1,236K
CDD
cd07920 (Pumilio)

1,047Q

RNA binding site
971N, 972F, 975Q, 1,007C, 1,008H, 1,011Q, 1,044H, 1,047Q, 1,083S, 1,084L, 1,087Q, 1,116Q, 1,117W, 1,119N, 1,120W, 1,123Q, 1,152Q, 1,153Y, 1,155S, 1,156K, 1,159E, 1,196A, 1,197H, 1,199N, 1,200Y, 1,203Q, 1,233W, 1,236K
CDD
cd07920 (Pumilio)

1,083S

RNA binding site
971N, 972F, 975Q, 1,007C, 1,008H, 1,011Q, 1,044H, 1,047Q, 1,083S, 1,084L, 1,087Q, 1,116Q, 1,117W, 1,119N, 1,120W, 1,123Q, 1,152Q, 1,153Y, 1,155S, 1,156K, 1,159E, 1,196A, 1,197H, 1,199N, 1,200Y, 1,203Q, 1,233W, 1,236K
CDD
cd07920 (Pumilio)

1,084L

RNA binding site
971N, 972F, 975Q, 1,007C, 1,008H, 1,011Q, 1,044H, 1,047Q, 1,083S, 1,084L, 1,087Q, 1,116Q, 1,117W, 1,119N, 1,120W, 1,123Q, 1,152Q, 1,153Y, 1,155S, 1,156K, 1,159E, 1,196A, 1,197H, 1,199N, 1,200Y, 1,203Q, 1,233W, 1,236K
CDD
cd07920 (Pumilio)

1,087Q

RNA binding site
971N, 972F, 975Q, 1,007C, 1,008H, 1,011Q, 1,044H, 1,047Q, 1,083S, 1,084L, 1,087Q, 1,116Q, 1,117W, 1,119N, 1,120W, 1,123Q, 1,152Q, 1,153Y, 1,155S, 1,156K, 1,159E, 1,196A, 1,197H, 1,199N, 1,200Y, 1,203Q, 1,233W, 1,236K
CDD
cd07920 (Pumilio)

1,116Q

RNA binding site
971N, 972F, 975Q, 1,007C, 1,008H, 1,011Q, 1,044H, 1,047Q, 1,083S, 1,084L, 1,087Q, 1,116Q, 1,117W, 1,119N, 1,120W, 1,123Q, 1,152Q, 1,153Y, 1,155S, 1,156K, 1,159E, 1,196A, 1,197H, 1,199N, 1,200Y, 1,203Q, 1,233W, 1,236K
CDD
cd07920 (Pumilio)

1,117W

RNA binding site
971N, 972F, 975Q, 1,007C, 1,008H, 1,011Q, 1,044H, 1,047Q, 1,083S, 1,084L, 1,087Q, 1,116Q, 1,117W, 1,119N, 1,120W, 1,123Q, 1,152Q, 1,153Y, 1,155S, 1,156K, 1,159E, 1,196A, 1,197H, 1,199N, 1,200Y, 1,203Q, 1,233W, 1,236K
CDD
cd07920 (Pumilio)

1,119N

RNA binding site
971N, 972F, 975Q, 1,007C, 1,008H, 1,011Q, 1,044H, 1,047Q, 1,083S, 1,084L, 1,087Q, 1,116Q, 1,117W, 1,119N, 1,120W, 1,123Q, 1,152Q, 1,153Y, 1,155S, 1,156K, 1,159E, 1,196A, 1,197H, 1,199N, 1,200Y, 1,203Q, 1,233W, 1,236K
CDD
cd07920 (Pumilio)

1,120W

RNA binding site
971N, 972F, 975Q, 1,007C, 1,008H, 1,011Q, 1,044H, 1,047Q, 1,083S, 1,084L, 1,087Q, 1,116Q, 1,117W, 1,119N, 1,120W, 1,123Q, 1,152Q, 1,153Y, 1,155S, 1,156K, 1,159E, 1,196A, 1,197H, 1,199N, 1,200Y, 1,203Q, 1,233W, 1,236K
CDD
cd07920 (Pumilio)

1,123Q

RNA binding site
971N, 972F, 975Q, 1,007C, 1,008H, 1,011Q, 1,044H, 1,047Q, 1,083S, 1,084L, 1,087Q, 1,116Q, 1,117W, 1,119N, 1,120W, 1,123Q, 1,152Q, 1,153Y, 1,155S, 1,156K, 1,159E, 1,196A, 1,197H, 1,199N, 1,200Y, 1,203Q, 1,233W, 1,236K
CDD
cd07920 (Pumilio)

1,152Q

RNA binding site
971N, 972F, 975Q, 1,007C, 1,008H, 1,011Q, 1,044H, 1,047Q, 1,083S, 1,084L, 1,087Q, 1,116Q, 1,117W, 1,119N, 1,120W, 1,123Q, 1,152Q, 1,153Y, 1,155S, 1,156K, 1,159E, 1,196A, 1,197H, 1,199N, 1,200Y, 1,203Q, 1,233W, 1,236K
CDD
cd07920 (Pumilio)

1,153Y

RNA binding site
971N, 972F, 975Q, 1,007C, 1,008H, 1,011Q, 1,044H, 1,047Q, 1,083S, 1,084L, 1,087Q, 1,116Q, 1,117W, 1,119N, 1,120W, 1,123Q, 1,152Q, 1,153Y, 1,155S, 1,156K, 1,159E, 1,196A, 1,197H, 1,199N, 1,200Y, 1,203Q, 1,233W, 1,236K
CDD
cd07920 (Pumilio)

1,155S

RNA binding site
971N, 972F, 975Q, 1,007C, 1,008H, 1,011Q, 1,044H, 1,047Q, 1,083S, 1,084L, 1,087Q, 1,116Q, 1,117W, 1,119N, 1,120W, 1,123Q, 1,152Q, 1,153Y, 1,155S, 1,156K, 1,159E, 1,196A, 1,197H, 1,199N, 1,200Y, 1,203Q, 1,233W, 1,236K
CDD
cd07920 (Pumilio)

1,156K

RNA binding site
971N, 972F, 975Q, 1,007C, 1,008H, 1,011Q, 1,044H, 1,047Q, 1,083S, 1,084L, 1,087Q, 1,116Q, 1,117W, 1,119N, 1,120W, 1,123Q, 1,152Q, 1,153Y, 1,155S, 1,156K, 1,159E, 1,196A, 1,197H, 1,199N, 1,200Y, 1,203Q, 1,233W, 1,236K
CDD
cd07920 (Pumilio)

1,159E

RNA binding site
971N, 972F, 975Q, 1,007C, 1,008H, 1,011Q, 1,044H, 1,047Q, 1,083S, 1,084L, 1,087Q, 1,116Q, 1,117W, 1,119N, 1,120W, 1,123Q, 1,152Q, 1,153Y, 1,155S, 1,156K, 1,159E, 1,196A, 1,197H, 1,199N, 1,200Y, 1,203Q, 1,233W, 1,236K
CDD
cd07920 (Pumilio)

1,196A

RNA binding site
971N, 972F, 975Q, 1,007C, 1,008H, 1,011Q, 1,044H, 1,047Q, 1,083S, 1,084L, 1,087Q, 1,116Q, 1,117W, 1,119N, 1,120W, 1,123Q, 1,152Q, 1,153Y, 1,155S, 1,156K, 1,159E, 1,196A, 1,197H, 1,199N, 1,200Y, 1,203Q, 1,233W, 1,236K
CDD
cd07920 (Pumilio)

1,197H

RNA binding site
971N, 972F, 975Q, 1,007C, 1,008H, 1,011Q, 1,044H, 1,047Q, 1,083S, 1,084L, 1,087Q, 1,116Q, 1,117W, 1,119N, 1,120W, 1,123Q, 1,152Q, 1,153Y, 1,155S, 1,156K, 1,159E, 1,196A, 1,197H, 1,199N, 1,200Y, 1,203Q, 1,233W, 1,236K
CDD
cd07920 (Pumilio)

1,199N

RNA binding site
971N, 972F, 975Q, 1,007C, 1,008H, 1,011Q, 1,044H, 1,047Q, 1,083S, 1,084L, 1,087Q, 1,116Q, 1,117W, 1,119N, 1,120W, 1,123Q, 1,152Q, 1,153Y, 1,155S, 1,156K, 1,159E, 1,196A, 1,197H, 1,199N, 1,200Y, 1,203Q, 1,233W, 1,236K
CDD
cd07920 (Pumilio)

1,200Y

RNA binding site
971N, 972F, 975Q, 1,007C, 1,008H, 1,011Q, 1,044H, 1,047Q, 1,083S, 1,084L, 1,087Q, 1,116Q, 1,117W, 1,119N, 1,120W, 1,123Q, 1,152Q, 1,153Y, 1,155S, 1,156K, 1,159E, 1,196A, 1,197H, 1,199N, 1,200Y, 1,203Q, 1,233W, 1,236K
CDD
cd07920 (Pumilio)

1,203Q

RNA binding site
971N, 972F, 975Q, 1,007C, 1,008H, 1,011Q, 1,044H, 1,047Q, 1,083S, 1,084L, 1,087Q, 1,116Q, 1,117W, 1,119N, 1,120W, 1,123Q, 1,152Q, 1,153Y, 1,155S, 1,156K, 1,159E, 1,196A, 1,197H, 1,199N, 1,200Y, 1,203Q, 1,233W, 1,236K
CDD
cd07920 (Pumilio)

1,233W

RNA binding site
971N, 972F, 975Q, 1,007C, 1,008H, 1,011Q, 1,044H, 1,047Q, 1,083S, 1,084L, 1,087Q, 1,116Q, 1,117W, 1,119N, 1,120W, 1,123Q, 1,152Q, 1,153Y, 1,155S, 1,156K, 1,159E, 1,196A, 1,197H, 1,199N, 1,200Y, 1,203Q, 1,233W, 1,236K
CDD
cd07920 (Pumilio)

1,236K

RNA binding site
971N, 972F, 975Q, 1,007C, 1,008H, 1,011Q, 1,044H, 1,047Q, 1,083S, 1,084L, 1,087Q, 1,116Q, 1,117W, 1,119N, 1,120W, 1,123Q, 1,152Q, 1,153Y, 1,155S, 1,156K, 1,159E, 1,196A, 1,197H, 1,199N, 1,200Y, 1,203Q, 1,233W, 1,236K
CDD
cd07920 (Pumilio)

Protein sequence

>MIA_00928_1
MDLYQKSQNIESFWALEVGKASPTNTDSLLTMSQSLVLDPLSSPLFFASDEQDLINEEDNDKEEVHANDEHQQLLQPSFS
SSNLMFAFSDLSLASSPCSFAKEATTHLATAGDTTGPARVELPVVTAEGLVATATTSASTRPASIGNTTSHENEEGKPAG
AAVATPATAKEDEEQASLLQHHQKLHQAPPGFCGYLGLAGGATRLQNNLHLPNINSTVRGTRKSSILPPSCLTKTSWTTT
TSATTTTIAPGLQKNNQISKTLLPLNPSMRANIWAPVVSLTDSKKTFAAAAAGTTTSGFSTLSSSSSLSSLSSSLASASS
SEIPFPFSLPLSRNKEDECLAKVLLPSLNTITKMPVVDDFEKDKQREEEDDAGMAGKNPLEEIERLKRELEKARNRIDEM
ETQRGSDRVAMMAMPGLGAPPTSTGTAVGFPTNRGFAVPARDYSPYGGPSFGMPGLGGQGRFQDLFQSNTSNRGGDNSPI
PYYPSPNPPPVAPVLYGPSLIKDQTIPVSPAPPVLQLSQQQQHKQMTQVPPAAAFPDPVVTANPTTTTSNVTATATMWVP
EFYAPRAHGMTAAAAAAAAIGGSGNGGQGQQGLGMDGGRMMMGMGMGGMDMMMYEGEGPAVGRGYLQGHTADAASAAGTA
GTAGGDGECVGVVMVEKDDGEQEDGEEQGATRTTTATTMPPINIPARSAYNMGIGPSAAPGDLGCTNGNGFVDVTSVGGG
CEEWFGARRGGVAAGSGDLWATPGVAGNMGMFVSGSVNPMLASYSDSYPGCWPVANNPGSVIVGNGPLPSQQQLPAKGLL
HHQPQNGGQARGSPMSGAQDVYYGYANGNSSSSSSSIGHNMKKGGPKPMMFSGMAGNGEYECENGFNDVCHFEYNDCIMD
AMFTNFLFWWFVFQVYYNIPINEPINYRRLLEKSATCDWRIIVNRIVHDNDQQASIFLQQKLKISNSEQRNLIIECISEQ
SYSLMVNRFGNFLIQRCLEYSNKAQIDALTGPIKGRVCALSKDPFGCHVVQKALDCVGEEMKHTVVAELLESVAETMVHR
YACHVWQKLFELRWTGPAPRFMARVNEELRGMWERVALEETGSLVVQNIFENCTEEDKRPCVEEIVAKMDVVICGQWGNW
VIQHMVECAAEPVRERVVALVLDKSPVYSTDQYASKVVEKLLKMGDKAVIQRFLDKVTAQRHGRPRIPLIDIASDAHGNY
LVQYILQSGTPAQQDEVAGQIRKHMVSLRGSKWGSKCAWLIDRNRANTSVTAVSKSLLKRG

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003723 RNA binding
GO:0005488 binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

MIA_00928_1

Protein function

Protein alignments

Mitochondrial localization by mitoprotII

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

Protein sequence

GO term prediction

Biological Process

Molecular Function

Cellular Component