MIA_00888_1

Protein

Length

610 amino acids

Protein function

EGGNOG:	0PFE6	FG02869.1	MFS multidrug transporter
SGD closest match:	S000003951	TPO1	Polyamine transporter 1
CGD closest match:	CAL0000181961	orf19.341	Uncharacterized protein

Protein alignments

	%id	Aln length	E-value
MCA_00877_1	63.197%	538	0.0	MCA_00877_1
A0A167D3I8_9ASCO	54.069%	553	0.0	Tpo3p OS=Sugiyamaella lignohabitans GN=TPO3 PE=4 SV=1
A0A060SYR6_BLAAD	52.974%	538	0.0	ARAD1A19096p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A19096g PE=4 SV=1
UniRef50_A0A060SYR6	52.974%	538	0.0	ARAD1A19096p n=1 Tax=Blastobotrys adeninivorans TaxID=409370 RepID=A0A060SYR6_BLAAD
Q6C539_YARLI	51.699%	559	0.0	YALI0E21241p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E21241g PE=4 SV=1
A0A1D8PJQ4_CANAL	45.505%	545	1.31e-164	Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.341 PE=4 SV=1
A0A1E4TF76_9ASCO	33.698%	457	4.93e-74	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_24563 PE=4 SV=1
A0A0J9X353_GEOCN	32.819%	518	7.05e-73	Similar to Saccharomyces cerevisiae YLL028W TPO1 Polyamine transporter that recognizes spermine, putrescine,and spermidine OS=Geotrichum candidum GN=BN980_GECA01s01011g PE=4 SV=1
A0A1E3PPH0_9ASCO	33.094%	556	7.61e-72	MFS general substrate transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81829 PE=4 SV=1
TPO1_YEAST	32.898%	459	7.90e-71	Polyamine transporter 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TPO1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0418

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
151 - 602
Major facilitator superfamily domain (IPR020846)

1 100 200 300 400 500 610

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  177 - 556
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. PS50850 (MFS)
  
  170 - 602
  
  PROSITE profiles
  PS50850 (MFS)
2. SSF103473 (MFS gene...)
  
  151 - 594
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
3. cd06174 (MFS)
  
  171 - 594
  
  CDD
  cd06174 (MFS)
IPR005829

Sugar transporter, conserved site
1. PS00216 (SUGAR_TRAN...)
  
  225 - 242
  
  PROSITE patterns
  PS00216 (SUGAR_TRANSPORT_1)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

230 - 235

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

599 - 610

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

461 - 480

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

285 - 295

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

346 - 404

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 167

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

529 - 539

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

148 - 372

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

390 - 602

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

501 - 505

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

428 - 438

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

256 - 260

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

318 - 322

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

190 - 208

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

563 - 573

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

540 - 562

TMHMM
TMhelix (TMhelix)

572 - 594

TMHMM
TMhelix (TMhelix)

210 - 232

TMHMM
TMhelix (TMhelix)

261 - 283

TMHMM
TMhelix (TMhelix)

237 - 254

TMHMM
TMhelix (TMhelix)

323 - 345

TMHMM
TMhelix (TMhelix)

168 - 190

TMHMM
TMhelix (TMhelix)

296 - 318

TMHMM
TMhelix (TMhelix)

405 - 427

TMHMM
TMhelix (TMhelix)

437 - 459

TMHMM
TMhelix (TMhelix)

506 - 528

TMHMM
TMhelix (TMhelix)

479 - 501

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

323 - 345

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

261 - 284

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

405 - 427

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

236 - 255

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

168 - 189

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

296 - 317

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

574 - 598

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

209 - 229

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

506 - 528

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

481 - 500

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

439 - 460

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

540 - 562

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
mobidb-lite (disord...)

1 - 67

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative substrate...

185S

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

188I

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

189A

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

190P

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

192I

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

193P

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

211V

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

214F

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

215V

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

218W

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

222P

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

223L

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

225V

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

226A

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

272G

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

273A

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

276I

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

277S

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

280A

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

281G

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

284A

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

296L

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

297A

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

300A

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

301L

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

307P

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

413Y

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

416L

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

417Y

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

420L

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

421V

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

424P

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

438T

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

442Y

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

446G

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

449F

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

453L

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

519T

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

522M

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

523I

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

526F

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

530Q

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

531N

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

534I

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

545M

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

546A

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

548A

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

549M

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

552R

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

553S

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

556G

putative substrate translocation pore
185S, 188I, 189A, 190P, 192I, 193P, 211V, 214F, 215V, 218W, 222P, 223L, 225V, 226A, 272G, 273A, 276I, 277S, 280A, 281G, 284A, 296L, 297A, 300A, 301L, 307P, 413Y, 416L, 417Y, 420L, 421V, 424P, 438T, 442Y, 446G, 449F, 453L, 519T, 522M, 523I, 526F, 530Q, 531N, 534I, 545M, 546A, 548A, 549M, 552R, 553S, 556G
CDD
cd06174 (MFS)

Protein sequence

>MIA_00888_1
MSSNENEKNPECSDEITVARKQQTLMSNENTLNENSDCPTEPRRSSDGSSSENSKFPYTTSDDDSKKFDLVSPSLSRVSN
HSVKSLYSESVIFGNLPQDEIDLERAKTREEILSRTTTRYIDDIVPKELGNGLLDDGEKAKDIDPELISWDNDEDPQNPR
NWPQNKKWLAVGIVASFTFTSPFSSSIIAPAIPDMAADLHITKEIEKSLSVSIFVLAWAICPLFVAPLSEVFGRRTILTT
ATIVMTIFHMATALSKNVTQLLVFRFLAGCAGALPISIGAGTMADLFNDKERGAALALYALGPTVGPVVAPIISGFIVEN
TSWRWVVWVLTMFSGIIAAFGFIFYPETYAPVILKWKAAKLRKETGNHNLHTVFEINQAPFKKQLLTAVIRPVRLLFLHP
IIQGLGLYMAFVYGFLYLLLVTFPTLWSVHYGFNLGITGLMYISLGVGFCTGLLFWSRVIQMTFIKLTKRNGGVSKPEYR
LYMVPFSALFLSVGLFWYGWSAQARIFWIMPCIGAGIFTFGMIAVFQSIQNYLIDMNPRFAASSMAAAMVFRSMLGFGFP
LFGKAMYDRMGYGWANSMTGLLCLVLGIPFPIIVIRYGEKIRLWANKRFV

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

GO:0005215 transporter activity

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features