MCA_00877_1

Protein

Length

607 amino acids

RNA-seq: read pairs 9856, FPKM 200.3, percentile rank 88.1% (100% = highest expression)

Protein function

EGGNOG:	0PFE6	FG02869.1	MFS multidrug transporter
SGD closest match:	S000005799	TPO4	Polyamine transporter 4
CGD closest match:	CAL0000181961	orf19.341	Uncharacterized protein

Protein alignments

	%id	Aln length	E-value
MIA_06084_1	71.14%	544	0.0	MIA_06084_1
A0A060SYR6_BLAAD	58.97%	524	1e-172	ARAD1A19096p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A19096g PE=4 SV=1
UniRef50_A0A060SYR6	58.97%	524	3e-169	ARAD1A19096p n=1 Tax=Blastobotrys adeninivorans TaxID=409370 RepID=A0A060SYR6_BLAAD
A0A167D3I8_9ASCO	56.58%	532	7e-172	Tpo3p OS=Sugiyamaella lignohabitans GN=TPO3 PE=4 SV=1
Q6C539_YARLI	52.92%	531	5e-167	YALI0E21241p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E21241g PE=4 SV=1
A0A1D8PJQ4_CANAL	44.30%	544	2e-133	Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.341 PE=4 SV=1
A0A1E3PN55_9ASCO	33.96%	480	9e-67	Putative MFS multidrug transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_73963 PE=4 SV=1
A0A1E4TLT0_9ASCO	32.55%	467	1e-61	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1322 PE=4 SV=1
A0A0J9XGW4_GEOCN	30.33%	488	7e-61	Similar to Saccharomyces cerevisiae YGR138C TPO2 Polyamine transport protein specific for spermine OS=Geotrichum candidum GN=BN980_GECA16s02617g PE=4 SV=1
TPO4_YEAST	30.29%	515	7e-48	Polyamine transporter 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TPO4 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0552

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
142 - 596
Major facilitator superfamily domain (IPR020846)

1 100 200 300 400 500 607

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  169 - 553
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. PS50850 (MFS)
  
  164 - 596
  
  PROSITE profiles
  PS50850 (MFS)
2. SSF103473 (MFS gene...)
  
  142 - 589
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
3. cd06174 (MFS)
  
  167 - 588
  
  CDD
  cd06174 (MFS)
IPR005829

Sugar transporter, conserved site
1. PS00216 (SUGAR_TRAN...)
  
  219 - 235
  
  PROSITE patterns
  PS00216 (SUGAR_TRANSPORT_1)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

592 - 607

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

279 - 289

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

340 - 394

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

220 - 230

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

524 - 543

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

455 - 474

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 161

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

142 - 367

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

389 - 601

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

251 - 255

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

312 - 316

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

495 - 499

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

187 - 197

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

562 - 566

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

422 - 432

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

317 - 339

TMHMM
TMhelix (TMhelix)

290 - 312

TMHMM
TMhelix (TMhelix)

501 - 523

TMHMM
TMhelix (TMhelix)

432 - 454

TMHMM
TMhelix (TMhelix)

167 - 186

TMHMM
TMhelix (TMhelix)

395 - 417

TMHMM
TMhelix (TMhelix)

256 - 278

TMHMM
TMhelix (TMhelix)

475 - 497

TMHMM
TMhelix (TMhelix)

201 - 223

TMHMM
TMhelix (TMhelix)

571 - 593

TMHMM
TMhelix (TMhelix)

544 - 561

TMHMM
TMhelix (TMhelix)

230 - 252

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

198 - 219

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

162 - 186

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

395 - 421

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

256 - 278

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

500 - 523

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

231 - 250

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

317 - 339

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

567 - 591

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

544 - 561

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

290 - 311

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

433 - 454

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

475 - 494

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
mobidb-lite (disord...)

1 - 73

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative substrate...

179S

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

182I

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

183S

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

184P

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

186V

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

187K

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

205V

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

208F

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

209V

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

212W

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

216P

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

217L

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

219V

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

220A

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

266G

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

267A

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

270L

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

271S

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

274A

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

275G

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

278A

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

290L

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

291A

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

294A

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

295V

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

301P

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

407Y

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

410M

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

411Y

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

414L

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

415V

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

418P

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

432T

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

436Y

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

440G

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

443F

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

447L

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

513G

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

516V

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

517V

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

520F

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

524Q

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

525N

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

528I

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

538S

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

539M

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

542A

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

543Q

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

546R

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

547S

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

550G

putative substrate translocation pore
179S, 182I, 183S, 184P, 186V, 187K, 205V, 208F, 209V, 212W, 216P, 217L, 219V, 220A, 266G, 267A, 270L, 271S, 274A, 275G, 278A, 290L, 291A, 294A, 295V, 301P, 407Y, 410M, 411Y, 414L, 415V, 418P, 432T, 436Y, 440G, 443F, 447L, 513G, 516V, 517V, 520F, 524Q, 525N, 528I, 538S, 539M, 542A, 543Q, 546R, 547S, 550G
CDD
cd06174 (MFS)

Protein sequence

>MCA_00877_1
MPSLKITKTPSSSSEDSYPEPAPLVHSTFTNSTGKDSDDSLSTSSKQNDHHDIEKQLKSQQSSLKPISSRASYRSIKSSY
SEKEIYGDLEPKIIDLERKKTREEVVSRVHSRRYIDAVQVEEEPNHLPDDGEDYVDIDPELVTWESEDDPENPRNWAPSK
KWMTTMIVALYTFVSPLASSIISPAVKDMGHDFNVTKPILLSLSVSLFVLAWAICPLFVAPLSELFGRKIVLNISIVLMA
LFNMCCAVSNNITMLLIFRFLAGCAGAPPLSIGAGTMADLFNDKDRNTALAVYAVGPTVGPIIAPIIAGFITENIGWRWV
LGVLTIFNAVIAAFGLMFYQETYAPILLQRKAQKLRKETGNEHLHTIFELTKIPFKKQLYIAVTRPIRILCTNPVVFSLG
LYMAFVYGFMYLMLVTFPALWNNYYGYNLGITGLMYLGLGVGFGFGLVFWAWIIQKVYLKLIEKNNGVSKPEYRLPMVPF
SAVSLGIGLIWYGFSAQARTMWLMPLIGTAFFGFGVVAVFQAIQNYLIDINPRFSASSMAAAQVFRSFCGFGFPLFGAAM
YDKLGYNYANLLSGILCFVLGIPAPILIYYYGERIRKWADQWMDDDN

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

GO:0005215 transporter activity

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features