Protein

MIA_00887_1

Length
1,230 amino acids

Browser: contig01:2501557-2505302-

Protein function

EGGNOG:0PGK4TOF1Forms a fork protection complex (FPC) with csm-3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors
SGD closest match:S000005217TOF1Topoisomerase 1-associated factor 1
CGD closest match:CAL0000201417YBL053Topoisomerase 1-associated factor 1

Protein alignments

%idAln lengthE-value
A0A0J9X9A7_GEOCN37.906%9550.0Similar to Saccharomyces cerevisiae YNL273W TOF1 Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion OS=Geotrichum candidum GN=BN980_GECA05s00879g PE=4 SV=1
UniRef50_A0A0J9X9A737.906%9551.31e-180Similar to Saccharomyces cerevisiae YNL273W TOF1 Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X9A7_GEOCN
A0A1E3PNY7_9ASCO34.096%9624.54e-139Timeless-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49586 PE=4 SV=1
MCA_05572_131.615%10281.14e-136MCA_05572_1
A0A060TAB9_BLAAD33.160%9621.37e-137ARAD1C44572p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C44572g PE=4 SV=1
TOF1_YARLI28.770%9352.97e-98Topoisomerase 1-associated factor 1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=TOF1 PE=3 SV=1
TOF1_YEAST24.849%9941.75e-63Topoisomerase 1-associated factor 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TOF1 PE=1 SV=1
A0A167CHG9_9ASCO37.766%3764.89e-68Tof1p OS=Sugiyamaella lignohabitans GN=TOF1 PE=4 SV=1
TOF1_CANAL26.570%8921.71e-62Topoisomerase 1-associated factor 1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=YBL053 PE=3 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0019

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 200 400 600 800 1000 1230

Detailed signature matches

  1. Domain IPR006906
    Timeless protein
    1. PF04821 (TIMELESS)
  2. Domain IPR007725
    Timeless C-terminal
    1. PF05029 (TIMELESS_C)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. NON_CYTOPLASM... (N...)
  3. TRANSMEMBRANE (Tran...)
  4. mobidb-lite (disord...)

Protein sequence

>MIA_00887_1
MNLEQEETIEPTTLEEPQDDFVELKAHIVNLVSALGGPDLAEESEPYVLGDDALGCLRDLKRWLKVYDEQNDSLDVARAI
SETSLVTFDLLEILTQWDIEEEQYEETEMEEGDQPINVEDDEDEEKRKKKYLRDKKTRIALACLELLVPLTWPISLTKTS
NPNHFIHMPYLEVAYLKYKNAILAHSEHRIFRAVIHLCLPALSTPENKRTLRHRSTLKLAVYFLRNIFRINYRDNMDNQF
EQLYLDTSRNTEVQIMKQQGVLDFLNALSSNISVTEFPYLNTPLMECLYYLLYGIDASVLFESTDKIILDENGQKNDLKS
LLSRDKAKENNLKSRLAKRTNRSSSLVTIKDSKGDTSAVILRAHTIGTADALDSIDEYKTKRLPKLSNHARMNIKSNVPG
ADNLDRFVENQWNVTILLTKEVRGVLREFCCDFLQMSFNPLFKILRNYFENEWMESAGKEFSNIVQYEHQIHFLYLASSF
LRIERTRLAIKFDQKEDVDFGLVAEVLIHNMFIIVMKMMRVSIEARAWAVVYTSMRCFNEIILTTNEMERIGDEETREIA
DNMKHRLFYLEEWLNTLAGLPVAARSQNESFVNLVVEVSYNVLSTLERFTKKNKEIYIQAGRRRRQVQKKNTGEENDEEM
DEEAEAMDRFIQEKRYNERKLDFAAFQRKYLKEDTVEMLTVYLSNYEDLSRRQIKWGLSLTHRFFVTAGYHVGFFRLDFM
RILDRLLESRAISMDLSTEFERFNKFFMRTLTSMLEKTPSLQWEILFHKEHARVFYLENGVTVEDTRASKPKVNRRIAGK
VGLPMQFLESEEYTAPREHRFRILVAALIDSEKRPLLKWAIKALEKAYDTRLAWISSSEVNNDVTIEEEALNPRLSPEMD
NKAVQEIEIGLRKNGTFRLLLKECQLRLDDNVDRTLCMLPRNALMETVKTCLDYMKRFNNEGTQFPDGKLAVAYLEEIKP
AKKRAGVNSRKGDDSGDEEGGGVDDDLDGFIERDSDDESGSEDDGSSEEEAQESGAEGGASKKKRRRKSSSDRRRKHKKP
KKDQQELPLRRRPIVRRVEYKSSEFITESDDEDDAERDHKFFEREAEQRIREKAKMDLLLKKPQAVTEPSSMEQSKKNNP
SQDSDLDNMSEEESNEPENESEEEEPIESDNEDEDIPTRFKKGSKKDRFKKSTQPFELEDSDVESEKSSDSEPEEKSGTE
SGPDSTENRESEELVEGVSISNISFEVAAV

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

None predicted.