MIA_00853_1

Protein

Length

345 amino acids

Protein function

EGGNOG:	0PHWD	GLO1	Lactoylglutathione lyase
SGD closest match:	S000004463	GLO1	Lactoylglutathione lyase
CGD closest match:	CAL0000175730	GLO1	Lactoylglutathione lyase

Protein alignments

	%id	Aln length	E-value
MCA_03209_1	73.011%	352	0.0	MCA_03209_1
A0A0J9X3R3_GEOCN	63.662%	355	1.87e-164	Lactoylglutathione lyase OS=Geotrichum candidum GN=BN980_GECA01s05092g PE=3 SV=1
A0A1E3PN94_9ASCO	60.064%	313	7.21e-137	Lactoylglutathione lyase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49352 PE=3 SV=1
A0A060T755_BLAAD	57.055%	326	1.53e-134	Lactoylglutathione lyase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B20636g PE=3 SV=1
A0A167F823_9ASCO	56.548%	336	2.52e-134	Lactoylglutathione lyase OS=Sugiyamaella lignohabitans GN=GLO1 PE=3 SV=1
Q6C4S7_YARLI	58.974%	312	3.89e-133	Lactoylglutathione lyase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E24057g PE=3 SV=1
UniRef50_A0A1D9QL59	52.147%	326	3.99e-116	Lactoylglutathione lyase n=3 Tax=leotiomyceta TaxID=716546 RepID=A0A1D9QL59_SCLS1
A0A1E4THB2_9ASCO	52.492%	301	1.54e-110	Lactoylglutathione lyase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_116574 PE=3 SV=1
Q5ABB2_CANAL	50.926%	324	9.78e-102	Lactoylglutathione lyase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GLO1 PE=3 SV=1
LGUL_YEAST	50.836%	299	5.37e-101	Lactoylglutathione lyase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GLO1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9762

Protein family membership

Glyoxalase I (IPR004361)

Domains and repeats

Domain
33 - 188
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase (IPR029068)
Glyoxalase/fosfomycin resistance/dioxygenase domain (IPR004360)
187 - 343
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase (IPR029068)
Glyoxalase/fosfomycin resistance/dioxygenase domain (IPR004360)

1 50 100 150 200 250 300 345

Detailed signature matches

IPR004361

Glyoxalase I
1. TIGR00068
  
  196 - 338
  
  TIGRFAMs
  TIGR00068 (TIGR00068)
IPR029068

Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
1. SSF54593 (Glyoxalas...)
  
  196 - 334
  
  SUPERFAMILY
  SSF54593 (Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase)
  
  43 - 188
  
  SUPERFAMILY
  SSF54593 (Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase)
2. G3DSA:3.10.18...
  
  187 - 343
  
  GENE3D
  G3DSA:3.10.180.10 (G3DSA:3.10.180.10)
  
  33 - 186
  
  GENE3D
  G3DSA:3.10.180.10 (G3DSA:3.10.180.10)
IPR004360

Glyoxalase/fosfomycin resistance/dioxygenase domain
1. PF00903 (Glyoxalase)
  
  44 - 180
  
  Pfam
  PF00903 (Glyoxalase)
  
  200 - 333
  
  Pfam
  PF00903 (Glyoxalase)
IPR018146

Glyoxalase I, conserved site
1. PS00935 (GLYOXALASE...)
  
  277 - 293
  
  PROSITE patterns
  PS00935 (GLYOXALASE_I_2)
  
  123 - 140
  
  PROSITE patterns
  PS00935 (GLYOXALASE_I_2)
2. PS00934 (GLYOXALASE...)
  
  46 - 67
  
  PROSITE patterns
  PS00934 (GLYOXALASE_I_1)

no IPR

Unintegrated signatures

cd07233 (GlxI_Zn)

45 - 181

CDD
cd07233 (GlxI_Zn)

201 - 334

CDD
cd07233 (GlxI_Zn)

Residue annotation

dimer interface cd...

45N

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

46H

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

47T

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

48M

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

50R

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

54P

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

55K

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

58V

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

59P

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

62E

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

63K

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

66G

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

69L

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

72K

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

73Y

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

83Y

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

87I

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

102G

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

104L

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

105E

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

109N

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

110Y

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

130G

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

131F

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

132G

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

133H

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

134I

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

135C

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

136F

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

137S

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

138V

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

139D

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

147R

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

176Y

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)

179E

dimer interface
45N, 46H, 47T, 48M, 50R, 54P, 55K, 58V, 59P, 62E, 63K, 66G, 69L, 72K, 73Y, 83Y, 87I, 102G, 104L, 105E, 109N, 110Y, 130G, 131F, 132G, 133H, 134I, 135C, 136F, 137S, 138V, 139D, 147R, 176Y, 179E
CDD
cd07233 (GlxI_Zn)
active site cd07233

46H

active site
46H, 50R, 75F, 80F, 82I, 105E, 107T, 109N, 133H, 157K, 167I, 169F, 177W, 179E
CDD
cd07233 (GlxI_Zn)

50R

active site
46H, 50R, 75F, 80F, 82I, 105E, 107T, 109N, 133H, 157K, 167I, 169F, 177W, 179E
CDD
cd07233 (GlxI_Zn)

75F

active site
46H, 50R, 75F, 80F, 82I, 105E, 107T, 109N, 133H, 157K, 167I, 169F, 177W, 179E
CDD
cd07233 (GlxI_Zn)

80F

active site
46H, 50R, 75F, 80F, 82I, 105E, 107T, 109N, 133H, 157K, 167I, 169F, 177W, 179E
CDD
cd07233 (GlxI_Zn)

82I

active site
46H, 50R, 75F, 80F, 82I, 105E, 107T, 109N, 133H, 157K, 167I, 169F, 177W, 179E
CDD
cd07233 (GlxI_Zn)

105E

active site
46H, 50R, 75F, 80F, 82I, 105E, 107T, 109N, 133H, 157K, 167I, 169F, 177W, 179E
CDD
cd07233 (GlxI_Zn)

107T

active site
46H, 50R, 75F, 80F, 82I, 105E, 107T, 109N, 133H, 157K, 167I, 169F, 177W, 179E
CDD
cd07233 (GlxI_Zn)

109N

active site
46H, 50R, 75F, 80F, 82I, 105E, 107T, 109N, 133H, 157K, 167I, 169F, 177W, 179E
CDD
cd07233 (GlxI_Zn)

133H

active site
46H, 50R, 75F, 80F, 82I, 105E, 107T, 109N, 133H, 157K, 167I, 169F, 177W, 179E
CDD
cd07233 (GlxI_Zn)

157K

active site
46H, 50R, 75F, 80F, 82I, 105E, 107T, 109N, 133H, 157K, 167I, 169F, 177W, 179E
CDD
cd07233 (GlxI_Zn)

167I

active site
46H, 50R, 75F, 80F, 82I, 105E, 107T, 109N, 133H, 157K, 167I, 169F, 177W, 179E
CDD
cd07233 (GlxI_Zn)

169F

active site
46H, 50R, 75F, 80F, 82I, 105E, 107T, 109N, 133H, 157K, 167I, 169F, 177W, 179E
CDD
cd07233 (GlxI_Zn)

177W

active site
46H, 50R, 75F, 80F, 82I, 105E, 107T, 109N, 133H, 157K, 167I, 169F, 177W, 179E
CDD
cd07233 (GlxI_Zn)

179E

active site
46H, 50R, 75F, 80F, 82I, 105E, 107T, 109N, 133H, 157K, 167I, 169F, 177W, 179E
CDD
cd07233 (GlxI_Zn)
metal binding site...

46H

metal binding site
46H, 105E, 133H, 179E
CDD
cd07233 (GlxI_Zn)

105E

metal binding site
46H, 105E, 133H, 179E
CDD
cd07233 (GlxI_Zn)

133H

metal binding site
46H, 105E, 133H, 179E
CDD
cd07233 (GlxI_Zn)

179E

metal binding site
46H, 105E, 133H, 179E
CDD
cd07233 (GlxI_Zn)
glutathione bindin...

50R

glutathione binding site
50R, 75F, 80F, 82I, 107T, 109N, 157K, 167I, 169F, 177W
CDD
cd07233 (GlxI_Zn)

75F

glutathione binding site
50R, 75F, 80F, 82I, 107T, 109N, 157K, 167I, 169F, 177W
CDD
cd07233 (GlxI_Zn)

80F

glutathione binding site
50R, 75F, 80F, 82I, 107T, 109N, 157K, 167I, 169F, 177W
CDD
cd07233 (GlxI_Zn)

82I

glutathione binding site
50R, 75F, 80F, 82I, 107T, 109N, 157K, 167I, 169F, 177W
CDD
cd07233 (GlxI_Zn)

107T

glutathione binding site
50R, 75F, 80F, 82I, 107T, 109N, 157K, 167I, 169F, 177W
CDD
cd07233 (GlxI_Zn)

109N

glutathione binding site
50R, 75F, 80F, 82I, 107T, 109N, 157K, 167I, 169F, 177W
CDD
cd07233 (GlxI_Zn)

157K

glutathione binding site
50R, 75F, 80F, 82I, 107T, 109N, 157K, 167I, 169F, 177W
CDD
cd07233 (GlxI_Zn)

167I

glutathione binding site
50R, 75F, 80F, 82I, 107T, 109N, 157K, 167I, 169F, 177W
CDD
cd07233 (GlxI_Zn)

169F

glutathione binding site
50R, 75F, 80F, 82I, 107T, 109N, 157K, 167I, 169F, 177W
CDD
cd07233 (GlxI_Zn)

177W

glutathione binding site
50R, 75F, 80F, 82I, 107T, 109N, 157K, 167I, 169F, 177W
CDD
cd07233 (GlxI_Zn)
dimer interface cd...

201N

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

202H

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

203S

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

204M

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

206R

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

210I

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

211K

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

214L

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

215K

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

218Q

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

219E

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

222G

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

225L

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

228T

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

229L

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

239Y

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

243Y

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

256A

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

258L

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

259E

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

263N

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

264W

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

283G

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

284Y

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

285G

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

286H

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

287I

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

288G

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

289I

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

290T

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

291V

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

292P

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

300E

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

329Y

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)

332E

dimer interface
201N, 202H, 203S, 204M, 206R, 210I, 211K, 214L, 215K, 218Q, 219E, 222G, 225L, 228T, 229L, 239Y, 243Y, 256A, 258L, 259E, 263N, 264W, 283G, 284Y, 285G, 286H, 287I, 288G, 289I, 290T, 291V, 292P, 300E, 329Y, 332E
CDD
cd07233 (GlxI_Zn)
metal binding site...

202H

metal binding site
202H, 259E, 286H, 332E
CDD
cd07233 (GlxI_Zn)

259E

metal binding site
202H, 259E, 286H, 332E
CDD
cd07233 (GlxI_Zn)

286H

metal binding site
202H, 259E, 286H, 332E
CDD
cd07233 (GlxI_Zn)

332E

metal binding site
202H, 259E, 286H, 332E
CDD
cd07233 (GlxI_Zn)
active site cd07233

202H

active site
202H, 206R, 231F, 236F, 238L, 259E, 261T, 263N, 286H, 310K, 320I, 322F, 330W, 332E
CDD
cd07233 (GlxI_Zn)

206R

active site
202H, 206R, 231F, 236F, 238L, 259E, 261T, 263N, 286H, 310K, 320I, 322F, 330W, 332E
CDD
cd07233 (GlxI_Zn)

231F

active site
202H, 206R, 231F, 236F, 238L, 259E, 261T, 263N, 286H, 310K, 320I, 322F, 330W, 332E
CDD
cd07233 (GlxI_Zn)

236F

active site
202H, 206R, 231F, 236F, 238L, 259E, 261T, 263N, 286H, 310K, 320I, 322F, 330W, 332E
CDD
cd07233 (GlxI_Zn)

238L

active site
202H, 206R, 231F, 236F, 238L, 259E, 261T, 263N, 286H, 310K, 320I, 322F, 330W, 332E
CDD
cd07233 (GlxI_Zn)

259E

active site
202H, 206R, 231F, 236F, 238L, 259E, 261T, 263N, 286H, 310K, 320I, 322F, 330W, 332E
CDD
cd07233 (GlxI_Zn)

261T

active site
202H, 206R, 231F, 236F, 238L, 259E, 261T, 263N, 286H, 310K, 320I, 322F, 330W, 332E
CDD
cd07233 (GlxI_Zn)

263N

active site
202H, 206R, 231F, 236F, 238L, 259E, 261T, 263N, 286H, 310K, 320I, 322F, 330W, 332E
CDD
cd07233 (GlxI_Zn)

286H

active site
202H, 206R, 231F, 236F, 238L, 259E, 261T, 263N, 286H, 310K, 320I, 322F, 330W, 332E
CDD
cd07233 (GlxI_Zn)

310K

active site
202H, 206R, 231F, 236F, 238L, 259E, 261T, 263N, 286H, 310K, 320I, 322F, 330W, 332E
CDD
cd07233 (GlxI_Zn)

320I

active site
202H, 206R, 231F, 236F, 238L, 259E, 261T, 263N, 286H, 310K, 320I, 322F, 330W, 332E
CDD
cd07233 (GlxI_Zn)

322F

active site
202H, 206R, 231F, 236F, 238L, 259E, 261T, 263N, 286H, 310K, 320I, 322F, 330W, 332E
CDD
cd07233 (GlxI_Zn)

330W

active site
202H, 206R, 231F, 236F, 238L, 259E, 261T, 263N, 286H, 310K, 320I, 322F, 330W, 332E
CDD
cd07233 (GlxI_Zn)

332E

active site
202H, 206R, 231F, 236F, 238L, 259E, 261T, 263N, 286H, 310K, 320I, 322F, 330W, 332E
CDD
cd07233 (GlxI_Zn)
glutathione bindin...

206R

glutathione binding site
206R, 231F, 236F, 238L, 261T, 263N, 310K, 320I, 322F, 330W
CDD
cd07233 (GlxI_Zn)

231F

glutathione binding site
206R, 231F, 236F, 238L, 261T, 263N, 310K, 320I, 322F, 330W
CDD
cd07233 (GlxI_Zn)

236F

glutathione binding site
206R, 231F, 236F, 238L, 261T, 263N, 310K, 320I, 322F, 330W
CDD
cd07233 (GlxI_Zn)

238L

glutathione binding site
206R, 231F, 236F, 238L, 261T, 263N, 310K, 320I, 322F, 330W
CDD
cd07233 (GlxI_Zn)

261T

glutathione binding site
206R, 231F, 236F, 238L, 261T, 263N, 310K, 320I, 322F, 330W
CDD
cd07233 (GlxI_Zn)

263N

glutathione binding site
206R, 231F, 236F, 238L, 261T, 263N, 310K, 320I, 322F, 330W
CDD
cd07233 (GlxI_Zn)

310K

glutathione binding site
206R, 231F, 236F, 238L, 261T, 263N, 310K, 320I, 322F, 330W
CDD
cd07233 (GlxI_Zn)

320I

glutathione binding site
206R, 231F, 236F, 238L, 261T, 263N, 310K, 320I, 322F, 330W
CDD
cd07233 (GlxI_Zn)

322F

glutathione binding site
206R, 231F, 236F, 238L, 261T, 263N, 310K, 320I, 322F, 330W
CDD
cd07233 (GlxI_Zn)

330W

glutathione binding site
206R, 231F, 236F, 238L, 261T, 263N, 310K, 320I, 322F, 330W
CDD
cd07233 (GlxI_Zn)

Protein sequence

>MIA_00853_1
MFRLKAISRQLISTNYSSSILSKQAFPKAANMSTSAIDTTGFKYNHTMIRIKDPKISVPFYEKNFGMKLYGKYSFKGFGF
DIYYLGIESSVPAGTPWYKREGLLELTHNYGTENDESYTLNNGNKEPHRGFGHICFSVDNINVACTRLEENGVKFQKKLT
DGRQKDIAFALDPDGYWIELISNKSIEPKPETTDLTKYRYNHSMIRVKDIKASLKFYQEILGMKLIRTLEFPEAKFSLYF
LGYSDTTEEEHSQREALLELTHNWGTENDPEFKYHNGNTAPQGYGHIGITVPDVPKAMAEFESAGVAIKKRVTDGKMNFI
GFILDPDNYWIEILPDQDLPEIKWD

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0004462 lactoylglutathione lyase activity
GO:0046872 metal ion binding

Cellular Component