MCA_03209_1

Protein

Length

350 amino acids

Gene name: GLO1

Description: Lactoylglutathione lyase

Browser: contigB:3676588-3677641+

RNA-seq: read pairs 7503, FPKM 264.1, percentile rank 90.9% (100% = highest expression)

Protein function

Annotation:		GLO1	Lactoylglutathione lyase
KEGG:	K01759	GLO1	lactoylglutathione lyase [EC:4.4.1.5]
EGGNOG:	0PHWD	GLO1	Lactoylglutathione lyase
SGD closest match:	S000004463	GLO1	Lactoylglutathione lyase
CGD closest match:	CAL0000175730	GLO1	Lactoylglutathione lyase

Protein alignments

	%id	Aln length	E-value
MIA_00853_1	73.01%	352	0.0	MIA_00853_1
A0A0J9X3R3_GEOCN	67.90%	324	2e-162	Lactoylglutathione lyase OS=Geotrichum candidum GN=BN980_GECA01s05092g PE=3 SV=1
Q6C4S7_YARLI	59.55%	314	6e-137	Lactoylglutathione lyase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E24057g PE=3 SV=1
A0A167F823_9ASCO	57.70%	331	7e-134	Lactoylglutathione lyase OS=Sugiyamaella lignohabitans GN=GLO1 PE=3 SV=1
A0A1E3PN94_9ASCO	59.94%	312	2e-129	Lactoylglutathione lyase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49352 PE=3 SV=1
A0A060T755_BLAAD	53.58%	349	1e-128	Lactoylglutathione lyase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B20636g PE=3 SV=1
UniRef50_A0A1D9QL59	52.29%	327	2e-114	Lactoylglutathione lyase n=3 Tax=leotiomyceta TaxID=716546 RepID=A0A1D9QL59_SCLS1
A0A1E4THB2_9ASCO	53.11%	305	8e-109	Lactoylglutathione lyase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_116574 PE=3 SV=1
LGUL_YEAST	48.94%	329	4e-100	Lactoylglutathione lyase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GLO1 PE=1 SV=1
Q5ABB2_CANAL	50.30%	328	4e-96	Lactoylglutathione lyase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GLO1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9376
Predicted cleavage: 19

Protein family membership

Glyoxalase I (IPR004361)

Domains and repeats

Domain
31 - 187
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase (IPR029068)
Glyoxalase/fosfomycin resistance/dioxygenase domain (IPR004360)
193 - 344
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase (IPR029068)
Glyoxalase/fosfomycin resistance/dioxygenase domain (IPR004360)

1 50 100 150 200 250 300 350 350

Detailed signature matches

IPR004361

Glyoxalase I
1. TIGR00068
  
  197 - 341
  
  TIGRFAMs
  TIGR00068 (TIGR00068)
IPR029068

Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
1. SSF54593 (Glyoxalas...)
  
  42 - 183
  
  SUPERFAMILY
  SSF54593 (Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase)
  
  196 - 340
  
  SUPERFAMILY
  SSF54593 (Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase)
2. G3DSA:3.10.18...
  
  31 - 187
  
  GENE3D
  G3DSA:3.10.180.10 (G3DSA:3.10.180.10)
  
  193 - 344
  
  GENE3D
  G3DSA:3.10.180.10 (G3DSA:3.10.180.10)
IPR004360

Glyoxalase/fosfomycin resistance/dioxygenase domain
1. PF00903 (Glyoxalase)
  
  201 - 338
  
  Pfam
  PF00903 (Glyoxalase)
  
  43 - 178
  
  Pfam
  PF00903 (Glyoxalase)
IPR018146

Glyoxalase I, conserved site
1. PS00935 (GLYOXALASE...)
  
  121 - 138
  
  PROSITE patterns
  PS00935 (GLYOXALASE_I_2)
  
  282 - 298
  
  PROSITE patterns
  PS00935 (GLYOXALASE_I_2)
2. PS00934 (GLYOXALASE...)
  
  44 - 65
  
  PROSITE patterns
  PS00934 (GLYOXALASE_I_1)

no IPR

Unintegrated signatures

Coil

136 - 156

COILS
Coil (Coil)
cd07233 (GlxI_Zn)

201 - 338

CDD
cd07233 (GlxI_Zn)

43 - 179

CDD
cd07233 (GlxI_Zn)

Residue annotation

dimer interface cd...

43N

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

44H

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

45T

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

46M

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

48R

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

52P

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

53K

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

56I

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

57P

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

60E

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

61K

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

64G

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

67I

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

70H

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

71T

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

81Y

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

85V

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

100G

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

102L

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

103E

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

107N

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

108Y

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

128G

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

129F

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

130G

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

131H

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

132I

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

133C

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

134F

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

135S

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

136V

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

137D

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

145R

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

174Y

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)

177E

dimer interface
43N, 44H, 45T, 46M, 48R, 52P, 53K, 56I, 57P, 60E, 61K, 64G, 67I, 70H, 71T, 81Y, 85V, 100G, 102L, 103E, 107N, 108Y, 128G, 129F, 130G, 131H, 132I, 133C, 134F, 135S, 136V, 137D, 145R, 174Y, 177E
CDD
cd07233 (GlxI_Zn)
metal binding site...

44H

metal binding site
44H, 103E, 131H, 177E
CDD
cd07233 (GlxI_Zn)

103E

metal binding site
44H, 103E, 131H, 177E
CDD
cd07233 (GlxI_Zn)

131H

metal binding site
44H, 103E, 131H, 177E
CDD
cd07233 (GlxI_Zn)

177E

metal binding site
44H, 103E, 131H, 177E
CDD
cd07233 (GlxI_Zn)
active site cd07233

44H

active site
44H, 48R, 73F, 78F, 80I, 103E, 105T, 107N, 131H, 155K, 165I, 167F, 175W, 177E
CDD
cd07233 (GlxI_Zn)

48R

active site
44H, 48R, 73F, 78F, 80I, 103E, 105T, 107N, 131H, 155K, 165I, 167F, 175W, 177E
CDD
cd07233 (GlxI_Zn)

73F

active site
44H, 48R, 73F, 78F, 80I, 103E, 105T, 107N, 131H, 155K, 165I, 167F, 175W, 177E
CDD
cd07233 (GlxI_Zn)

78F

active site
44H, 48R, 73F, 78F, 80I, 103E, 105T, 107N, 131H, 155K, 165I, 167F, 175W, 177E
CDD
cd07233 (GlxI_Zn)

80I

active site
44H, 48R, 73F, 78F, 80I, 103E, 105T, 107N, 131H, 155K, 165I, 167F, 175W, 177E
CDD
cd07233 (GlxI_Zn)

103E

active site
44H, 48R, 73F, 78F, 80I, 103E, 105T, 107N, 131H, 155K, 165I, 167F, 175W, 177E
CDD
cd07233 (GlxI_Zn)

105T

active site
44H, 48R, 73F, 78F, 80I, 103E, 105T, 107N, 131H, 155K, 165I, 167F, 175W, 177E
CDD
cd07233 (GlxI_Zn)

107N

active site
44H, 48R, 73F, 78F, 80I, 103E, 105T, 107N, 131H, 155K, 165I, 167F, 175W, 177E
CDD
cd07233 (GlxI_Zn)

131H

active site
44H, 48R, 73F, 78F, 80I, 103E, 105T, 107N, 131H, 155K, 165I, 167F, 175W, 177E
CDD
cd07233 (GlxI_Zn)

155K

active site
44H, 48R, 73F, 78F, 80I, 103E, 105T, 107N, 131H, 155K, 165I, 167F, 175W, 177E
CDD
cd07233 (GlxI_Zn)

165I

active site
44H, 48R, 73F, 78F, 80I, 103E, 105T, 107N, 131H, 155K, 165I, 167F, 175W, 177E
CDD
cd07233 (GlxI_Zn)

167F

active site
44H, 48R, 73F, 78F, 80I, 103E, 105T, 107N, 131H, 155K, 165I, 167F, 175W, 177E
CDD
cd07233 (GlxI_Zn)

175W

active site
44H, 48R, 73F, 78F, 80I, 103E, 105T, 107N, 131H, 155K, 165I, 167F, 175W, 177E
CDD
cd07233 (GlxI_Zn)

177E

active site
44H, 48R, 73F, 78F, 80I, 103E, 105T, 107N, 131H, 155K, 165I, 167F, 175W, 177E
CDD
cd07233 (GlxI_Zn)
glutathione bindin...

48R

glutathione binding site
48R, 73F, 78F, 80I, 105T, 107N, 155K, 165I, 167F, 175W
CDD
cd07233 (GlxI_Zn)

73F

glutathione binding site
48R, 73F, 78F, 80I, 105T, 107N, 155K, 165I, 167F, 175W
CDD
cd07233 (GlxI_Zn)

78F

glutathione binding site
48R, 73F, 78F, 80I, 105T, 107N, 155K, 165I, 167F, 175W
CDD
cd07233 (GlxI_Zn)

80I

glutathione binding site
48R, 73F, 78F, 80I, 105T, 107N, 155K, 165I, 167F, 175W
CDD
cd07233 (GlxI_Zn)

105T

glutathione binding site
48R, 73F, 78F, 80I, 105T, 107N, 155K, 165I, 167F, 175W
CDD
cd07233 (GlxI_Zn)

107N

glutathione binding site
48R, 73F, 78F, 80I, 105T, 107N, 155K, 165I, 167F, 175W
CDD
cd07233 (GlxI_Zn)

155K

glutathione binding site
48R, 73F, 78F, 80I, 105T, 107N, 155K, 165I, 167F, 175W
CDD
cd07233 (GlxI_Zn)

165I

glutathione binding site
48R, 73F, 78F, 80I, 105T, 107N, 155K, 165I, 167F, 175W
CDD
cd07233 (GlxI_Zn)

167F

glutathione binding site
48R, 73F, 78F, 80I, 105T, 107N, 155K, 165I, 167F, 175W
CDD
cd07233 (GlxI_Zn)

175W

glutathione binding site
48R, 73F, 78F, 80I, 105T, 107N, 155K, 165I, 167F, 175W
CDD
cd07233 (GlxI_Zn)
dimer interface cd...

201F

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

202N

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

203H

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

204S

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

205M

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

207R

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

211A

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

212K

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

215L

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

216K

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

219E

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

220E

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

223G

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

226L

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

229T

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

230K

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

240Y

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

244H

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

261G

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

263L

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

264E

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

268N

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

269W

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

288G

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

289Y

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

290G

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

291H

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

292I

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

293G

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

294V

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

295T

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

296V

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

297P

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

305Q

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

334Y

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)

337E

dimer interface
201F, 202N, 203H, 204S, 205M, 207R, 211A, 212K, 215L, 216K, 219E, 220E, 223G, 226L, 229T, 230K, 240Y, 244H, 261G, 263L, 264E, 268N, 269W, 288G, 289Y, 290G, 291H, 292I, 293G, 294V, 295T, 296V, 297P, 305Q, 334Y, 337E
CDD
cd07233 (GlxI_Zn)
metal binding site...

203H

metal binding site
203H, 264E, 291H, 337E
CDD
cd07233 (GlxI_Zn)

264E

metal binding site
203H, 264E, 291H, 337E
CDD
cd07233 (GlxI_Zn)

291H

metal binding site
203H, 264E, 291H, 337E
CDD
cd07233 (GlxI_Zn)

337E

metal binding site
203H, 264E, 291H, 337E
CDD
cd07233 (GlxI_Zn)
active site cd07233

203H

active site
203H, 207R, 232F, 237F, 239L, 264E, 266T, 268N, 291H, 315K, 325I, 327F, 335W, 337E
CDD
cd07233 (GlxI_Zn)

207R

active site
203H, 207R, 232F, 237F, 239L, 264E, 266T, 268N, 291H, 315K, 325I, 327F, 335W, 337E
CDD
cd07233 (GlxI_Zn)

232F

active site
203H, 207R, 232F, 237F, 239L, 264E, 266T, 268N, 291H, 315K, 325I, 327F, 335W, 337E
CDD
cd07233 (GlxI_Zn)

237F

active site
203H, 207R, 232F, 237F, 239L, 264E, 266T, 268N, 291H, 315K, 325I, 327F, 335W, 337E
CDD
cd07233 (GlxI_Zn)

239L

active site
203H, 207R, 232F, 237F, 239L, 264E, 266T, 268N, 291H, 315K, 325I, 327F, 335W, 337E
CDD
cd07233 (GlxI_Zn)

264E

active site
203H, 207R, 232F, 237F, 239L, 264E, 266T, 268N, 291H, 315K, 325I, 327F, 335W, 337E
CDD
cd07233 (GlxI_Zn)

266T

active site
203H, 207R, 232F, 237F, 239L, 264E, 266T, 268N, 291H, 315K, 325I, 327F, 335W, 337E
CDD
cd07233 (GlxI_Zn)

268N

active site
203H, 207R, 232F, 237F, 239L, 264E, 266T, 268N, 291H, 315K, 325I, 327F, 335W, 337E
CDD
cd07233 (GlxI_Zn)

291H

active site
203H, 207R, 232F, 237F, 239L, 264E, 266T, 268N, 291H, 315K, 325I, 327F, 335W, 337E
CDD
cd07233 (GlxI_Zn)

315K

active site
203H, 207R, 232F, 237F, 239L, 264E, 266T, 268N, 291H, 315K, 325I, 327F, 335W, 337E
CDD
cd07233 (GlxI_Zn)

325I

active site
203H, 207R, 232F, 237F, 239L, 264E, 266T, 268N, 291H, 315K, 325I, 327F, 335W, 337E
CDD
cd07233 (GlxI_Zn)

327F

active site
203H, 207R, 232F, 237F, 239L, 264E, 266T, 268N, 291H, 315K, 325I, 327F, 335W, 337E
CDD
cd07233 (GlxI_Zn)

335W

active site
203H, 207R, 232F, 237F, 239L, 264E, 266T, 268N, 291H, 315K, 325I, 327F, 335W, 337E
CDD
cd07233 (GlxI_Zn)

337E

active site
203H, 207R, 232F, 237F, 239L, 264E, 266T, 268N, 291H, 315K, 325I, 327F, 335W, 337E
CDD
cd07233 (GlxI_Zn)
glutathione bindin...

207R

glutathione binding site
207R, 232F, 237F, 239L, 266T, 268N, 315K, 325I, 327F, 335W
CDD
cd07233 (GlxI_Zn)

232F

glutathione binding site
207R, 232F, 237F, 239L, 266T, 268N, 315K, 325I, 327F, 335W
CDD
cd07233 (GlxI_Zn)

237F

glutathione binding site
207R, 232F, 237F, 239L, 266T, 268N, 315K, 325I, 327F, 335W
CDD
cd07233 (GlxI_Zn)

239L

glutathione binding site
207R, 232F, 237F, 239L, 266T, 268N, 315K, 325I, 327F, 335W
CDD
cd07233 (GlxI_Zn)

266T

glutathione binding site
207R, 232F, 237F, 239L, 266T, 268N, 315K, 325I, 327F, 335W
CDD
cd07233 (GlxI_Zn)

268N

glutathione binding site
207R, 232F, 237F, 239L, 266T, 268N, 315K, 325I, 327F, 335W
CDD
cd07233 (GlxI_Zn)

315K

glutathione binding site
207R, 232F, 237F, 239L, 266T, 268N, 315K, 325I, 327F, 335W
CDD
cd07233 (GlxI_Zn)

325I

glutathione binding site
207R, 232F, 237F, 239L, 266T, 268N, 315K, 325I, 327F, 335W
CDD
cd07233 (GlxI_Zn)

327F

glutathione binding site
207R, 232F, 237F, 239L, 266T, 268N, 315K, 325I, 327F, 335W
CDD
cd07233 (GlxI_Zn)

335W

glutathione binding site
207R, 232F, 237F, 239L, 266T, 268N, 315K, 325I, 327F, 335W
CDD
cd07233 (GlxI_Zn)

Protein sequence

>MCA_03209_1
MNRLKAFARQLTPFTPKKIQSNSFSNMTTTYSPAIETAGFNYNHTMIRIKDPKISIPFYEKNFGLKIQGHTKFKGFGFDI
YYLGVESSVAPGTPWYNRGGLLELTHNYGTENDESYTLNNGNKEPHRGFGHICFSVDNIEAACERLENNGVKFQKKLTDG
RQKDIAFALDPDGYWIEIISNHTLSADSIKEGVTDLTTYRFNHSMIRVKDAKESLKFYEEVLGMKLLRTKEFPEAKFTLY
FLGHCEGDKPTPEELVSGREGLLELTHNWGTENDPDFHYHNGNDQPQGYGHIGVTVPDVKKAMDQFEAAGVKIKKRMTDG
KMKFIGFILDPDNYWIEIMPAAELPPIEWD

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0004462 lactoylglutathione lyase activity
GO:0046872 metal ion binding

Cellular Component