Protein

MIA_00851_1

Length
799 amino acids

Browser: contig01:2403410-2405810-

Protein function

EGGNOG:0PGCHMAK5ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs (By similarity)
SGD closest match:S000000346MAK5ATP-dependent RNA helicase MAK5
CGD closest match:CAL0000200900MAK5ATP-dependent RNA helicase MAK5

Protein alignments

%idAln lengthE-value
A0A0J9X9S7_GEOCN64.013%6030.0Similar to Saccharomyces cerevisiae YBR142W MAK5 Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus OS=Geotrichum candidum GN=BN980_GECA06s02353g PE=3 SV=1
UniRef50_A0A0J9X9S764.013%6030.0Similar to Saccharomyces cerevisiae YBR142W MAK5 Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X9S7_GEOCN
A0A167F066_9ASCO58.120%5850.0Mak5p OS=Sugiyamaella lignohabitans GN=MAK5 PE=3 SV=1
MCA_03211_152.104%6890.0MCA_03211_1
A0A1E3PMJ2_9ASCO48.414%7250.0DEAD-domain-containing protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_5291 PE=4 SV=1
A0A060TC58_BLAAD47.532%7091.32e-164ARAD1B20592p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B20592g PE=3 SV=1
MAK5_CANAL49.191%6181.80e-162ATP-dependent RNA helicase MAK5 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MAK5 PE=3 SV=2
Q6CHU3_YARLI51.745%4872.62e-157YALI0A04939p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A04939g PE=4 SV=1
MAK5_YEAST42.784%5893.15e-139ATP-dependent RNA helicase MAK5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MAK5 PE=1 SV=1
A0A1E4TMA2_9ASCO43.729%6065.90e-133Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30893 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0603

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 100 200 300 400 500 600 700 799

Detailed signature matches

  1. Domain IPR014014
    RNA helicase, DEAD-box type, Q motif
    1. PS51195 (Q_MOTIF)
  2. Domain IPR014001
    Helicase superfamily 1/2, ATP-binding domain
    1. PS51192 (HELICASE_A...)
    2. SM00487 (ultradead3)
  3. Domain IPR011545
    DEAD/DEAH box helicase domain
    1. PF00270 (DEAD)
  4. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  5. Domain IPR001650
    Helicase, C-terminal
    1. PS51194 (HELICASE_CTER)
    2. SM00490 (helicmild6)
    3. PF00271 (Helicase_C)
  6. SITE IPR000629
    ATP-dependent RNA helicase DEAD-box, conserved site
    1. PS00039 (DEAD_ATP_H...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.40.50...
  3. cd00079 (HELICc)
  4. mobidb-lite (disord...)

Residue annotation

  1. nucleotide binding...
  2. ATP-binding site c...

Protein sequence

>MIA_00851_1
MTEVKKETKKKHESTVKDTTTNTKGFLKEKNTHKDSKVESKDISNNTKKISKNNKKFLKNKKKHPKKKLSPEDGVDGVIT
LDADSLDWHSVDIDRRVNDFEGFFGLEELEGVSVERQDDGKVKFIQKEKKKPHNNIRQKDSANDIVKLEEEDDKDKALED
EQVSEEKSQVQDQQNLNSEANKKIKVKKEEEDSETTTKEVFKDDEEIKCEDEVADVFTTLEEVKIDTSNLEWDFNDEGAT
QLSEFANKALAALNFNKPTEIQVQTIPFILQNHDVIGKAATGSGKTLAYGLPILEKHLALIKDLQENNIIKNWPTAIIFS
PTRELAIQIVKHISTLAKYYPLIKGSSGIVPITGGLSIQKQQRLVQNKPAVIVATPGRFLELLESSNSIIELFSKAELIV
LDEADRMLQEGHFKELENALDLLGRGKKSKRQTLVFSATFQRDFMNKLGAKHKTNVGSNGRLSSNDDAIIFLKKKLRFKD
KNPKFVDVNPAEAVASKVHEAIIECGAMEKDLYLYYFTLLYPGRTIVFVNSIDAVKRLQPLLRELGIAATGLHSNMVQKQ
RLRSLEKFRENESSVLIATDVAARGLDIPMIQHVVHYNLPRTADMYVHRSGRTARAGSEGVSVIICSPEEASGPLVKLKR
VLYRDQVRNNNPISTFDIDYDVIKRIRPRVVIAKKISDSVQESTYKGKDTNWLQEAADDLGIDLDELEDSSKKQKGWMPF
EKKDQEKKILRKGDLRKLREELDELLAKPVLNRSGKYLTNGTINLAQMVVTGQSHDAVIGKDKSSALESLMNPRKKQKK

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003676 nucleic acid binding
GO:0005524 ATP binding

Cellular Component

None predicted.