Protein

MCA_03211_1

Length
895 amino acids


Gene name: MAK5

Description: ATP-dependent RNA helicase MAK5

Browser: contigB:3678670-3681358+

RNA-seq: read pairs 1050, FPKM 14.5, percentile rank 33.2% (100% = highest expression)

Protein function

Annotation:MAK5ATP-dependent RNA helicase MAK5
KEGG:K14805DDX24 ATP-dependent RNA helicase DDX24/MAK5 [EC:3.6.4.13]
EGGNOG:0PGCHMAK5ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs (By similarity)
SGD closest match:S000000346MAK5ATP-dependent RNA helicase MAK5
CGD closest match:CAL0000200900MAK5ATP-dependent RNA helicase MAK5

Protein alignments

%idAln lengthE-value
MIA_00851_152.18%6880.0MIA_00851_1
A0A0J9X9S7_GEOCN52.08%6970.0Similar to Saccharomyces cerevisiae YBR142W MAK5 Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus OS=Geotrichum candidum GN=BN980_GECA06s02353g PE=3 SV=1
UniRef50_A0A0J9X9S752.08%6970.0Similar to Saccharomyces cerevisiae YBR142W MAK5 Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X9S7_GEOCN
A0A167F066_9ASCO46.89%6911e-179Mak5p OS=Sugiyamaella lignohabitans GN=MAK5 PE=3 SV=1
A0A1E3PMJ2_9ASCO45.39%6831e-171DEAD-domain-containing protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_5291 PE=4 SV=1
A0A060TC58_BLAAD43.96%6622e-148ARAD1B20592p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B20592g PE=3 SV=1
Q6CHU3_YARLI44.63%5961e-143YALI0A04939p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A04939g PE=4 SV=1
MAK5_CANAL42.14%6813e-141ATP-dependent RNA helicase MAK5 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MAK5 PE=3 SV=2
MAK5_YEAST39.20%6995e-133ATP-dependent RNA helicase MAK5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MAK5 PE=1 SV=1
A0A1E4TMA2_9ASCO38.40%6643e-125Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30893 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.7355

Protein family membership

None predicted.

Domains and repeats

1 100 200 300 400 500 600 700 800 895

Detailed signature matches

    1. PS51195 (Q_MOTIF)
    1. PS51192 (HELICASE_A...)
    2. SM00487 (ultradead3)
    1. PF00270 (DEAD)
    1. SSF52540 (P-loop co...)
    1. PS51194 (HELICASE_CTER)
    2. SM00490 (helicmild6)
    3. PF00271 (Helicase_C)
    1. PS00039 (DEAD_ATP_H...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. cd00079 (HELICc)
  2. mobidb-lite (disord...)

Residue annotation

  1. nucleotide binding...
  2. ATP-binding site c...

Protein sequence

>MCA_03211_1
MAVDKTNKTKLKGKFLSIKKASAAKKPASEGGIKKNIAVKTAINKLKSKKSKKAKPQSNQEKKNNSAKERKVITETADPD
ALNWNPVEVNRRVDDFEGFFGLEELEGVTVEKADSGDVKFVQKEVKNKPKEKRKRQSEESEAQKRQEAWLENPLIDQDNI
EDLKESDKEEEEDSKSEDDKEGDNESSIPKKRKIEPKGPAIVEIPKQLKEIDTSVLEWPEMEKETLSIYAKRALVSLNFL
KPTEIQAKAIPEILAGNDVIGKAATGSGKTLAYGLPILEKHLELVLKSRPFAEQVAVEEKKWPTGLIFSPTRELAVQIQK
HLKAVSHYYPFEISTSNTKEAKEGDNSKSEDNAAFFSTVMSVTGGLSLQKQQRLLKSHPSIVVATPGRFLELLESDDAWI
EMFQKTEIVVLDEADRMLQEGHFQEMQKILDLLTVRDVKITTSIIEKAPKSDDEAQETKQIVKKKKKFGQVKRQTLVFSA
TFQQEFMHKLSSNKGKGGNSFVNTGRLSTNEEAMSFLQKKIRFRQQKPKFIDANPAENVAKSIYEAIIECDKMEKDLYLY
YFTLLYPGRTLVFVNSIDAVKRITPLLKELYCPPTTQQNSDERRSNVVVVGLHSHMIQKQRLRSIERFTSPNSKNAIMVA
TDVAARGLDIPLVQHVVHYNLPRTADMYVHRAGRTARAGEQGVSVILCAPEEASGPLAKLKRMLYNTPASKKEKPVSIEG
DEEDKEGEKKKQQALPPKRPGLKYFDVEHDVITRIKPRVTLAKKISDSVLQSTYKGKDESWIREAADDLGVDLDDNEFAS
IFKNSKRPNLNANSKQPQSNKDDEKILTKDELAYLRRQLKELLDQPVMMKKTSAKYLTSGSVNLAQLVISGGSHETVIGK
EKQTAIENITTKKKK

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003676 nucleic acid binding
GO:0005524 ATP binding

Cellular Component

None predicted.