MIA_00790_1

Protein

Length

594 amino acids

Protein function

EGGNOG:	0PGSS		Major Facilitator Superfamily
SGD closest match:	S000001428	YIL166C	Uncharacterized transporter YIL166C
CGD closest match:	CAL0000201100	orf19.6520	Uncharacterized protein

Protein alignments

	%id	Aln length	E-value
A0A0J9YHM4_GEOCN	65.936%	593	0.0	Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA01s06654g PE=4 SV=1
A0A167D9I1_9ASCO	60.179%	560	0.0	Uncharacterized protein OS=Sugiyamaella lignohabitans GN=AWJ20_906 PE=4 SV=1
A0A1E3PQH2_9ASCO	55.872%	596	0.0	MFS general substrate transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_19598 PE=4 SV=1
UniRef50_A3LWD0	61.933%	507	0.0	Putative allantoate permease n=276 Tax=Dikarya TaxID=451864 RepID=A3LWD0_PICST
Q6CEE0_YARLI	56.216%	555	0.0	YALI0B16412p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B16412g PE=4 SV=1
A0A1D8PQZ7_CANAL	60.750%	507	0.0	Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.6520 PE=4 SV=1
A0A060T3B5_BLAAD	53.458%	535	0.0	ARAD1C35992p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C35992g PE=4 SV=1
YIQ6_YEAST	49.902%	509	1.47e-161	Uncharacterized transporter YIL166C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YIL166C PE=1 SV=1
A0A1E4TA29_9ASCO	27.381%	504	8.97e-34	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_124711 PE=4 SV=1
MCA_01418_1	22.030%	463	2.09e-29	MCA_01418_1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0061

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
115 - 554
Major facilitator superfamily domain (IPR020846)

1 100 200 300 400 500 594

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  140 - 517
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. SSF103473 (MFS gene...)
  
  115 - 554
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
2. cd06174 (MFS)
  
  135 - 518
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

1 - 225

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

557 - 594

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

283 - 293

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

398 - 408

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

490 - 500

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

352 - 584

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

122 - 327

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

431 - 465

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

250 - 260

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

314 - 374

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

522 - 535

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

291 - 313

TMHMM
TMhelix (TMhelix)

534 - 556

TMHMM
TMhelix (TMhelix)

374 - 396

TMHMM
TMhelix (TMhelix)

225 - 247

TMHMM
TMhelix (TMhelix)

465 - 487

TMHMM
TMhelix (TMhelix)

441 - 458

TMHMM
TMhelix (TMhelix)

262 - 284

TMHMM
TMhelix (TMhelix)

409 - 431

TMHMM
TMhelix (TMhelix)

502 - 521

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

375 - 397

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

501 - 521

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

226 - 249

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

536 - 556

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

409 - 430

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

466 - 489

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

294 - 313

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

261 - 282

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

Residue annotation

putative substrate...

149R

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

152I

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

153A

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

154Q

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

156L

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

157S

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

175Q

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

178F

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

179Y

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

182F

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

186E

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

187L

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

189S

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

190Q

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

236E

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

237G

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

240I

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

241A

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

244I

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

245S

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

248S

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

260L

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

261S

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

264W

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

265T

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

271Q

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

385Y

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

388T

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

389S

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

392N

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

393A

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

396T

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

409T

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

413T

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

417H

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

420H

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

424L

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

474V

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

477S

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

478G

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

481I

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

485L

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

486V

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

489C

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

500T

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

501V

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

506Y

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

507N

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

510V

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

511Q

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

514G

putative substrate translocation pore
149R, 152I, 153A, 154Q, 156L, 157S, 175Q, 178F, 179Y, 182F, 186E, 187L, 189S, 190Q, 236E, 237G, 240I, 241A, 244I, 245S, 248S, 260L, 261S, 264W, 265T, 271Q, 385Y, 388T, 389S, 392N, 393A, 396T, 409T, 413T, 417H, 420H, 424L, 474V, 477S, 478G, 481I, 485L, 486V, 489C, 500T, 501V, 506Y, 507N, 510V, 511Q, 514G
CDD
cd06174 (MFS)

Protein sequence

>MIA_00790_1
MTKKDNVILTTKSLDSKEHVDEDAYGPDGSYVPRDGDIVTKSGNVITEDGIVLKHAPTAGSSDVEKLGEGDASDHKGLRV
FYGKSHIFQDPEVADYYRGVYEKATYEGRHHFDPDFTWEPAEEKALVRRLEWKACFWACVMFMALQLDRGNIAQALSDNM
LNDLGLTTNDYNTGQTIFYLTFLAAELPSQLVSKKLGPDRWIPAQITLWSIVAICQSQLSGKASFFATRAIIGLLEGGFI
ADTISWLSYFYTGTELPVRLSFFWTSLTLTQIFSSLAAFGILRMRGIRGWGGWRWLFLLEGLLTLLIGIASFFKMPASPV
QTRAPWRPKGWFTEREEKIIVNRILRDDPSKGDMHNRQAVSIKQLWYSLIDFDLWPLYFIGLVAYIPTSTVNAYMTLTLR
QLGFSTFDTNLLTIPAHVVHIIFLLSQTYLTEYFNERSLSATLQPLWILPCIGTLAFWSQSLTNVWGTYALLTVLLSGPY
IHAILVGWCSRNSNTVRTRTVSAAVYNMFVQAGGIIASNIYRKNDSPKYRKGNRVLFGITFVSLTLLLFTKGYYIWKNHS
REKIWGAMTTEEQHNYRATTKDKGNKRLNFRFAH

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features