MCA_01418_1

Protein

Length

551 amino acids

Browser: contigA:4410335-4411991-

RNA-seq: read pairs 572, FPKM 12.8, percentile rank 30.6% (100% = highest expression)

Protein function

EGGNOG:	0PJ5U		(Mfs) transporter
SGD closest match:	S000003492	TNA1	High-affinity nicotinic acid transporter
CGD closest match:	CAL0000199600	CAALFM_CR01220WA	Uncharacterized protein

Protein alignments

	%id	Aln length	E-value
MIA_00389_1	65.21%	549	0.0	MIA_00389_1
A0A060T5B6_BLAAD	46.41%	487	3e-163	ARAD1C04268p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C04268g PE=4 SV=1
A0A167CP40_9ASCO	41.80%	500	3e-144	Tna1p OS=Sugiyamaella lignohabitans GN=TNA1 PE=4 SV=1
UniRef50_A0A167CP40	41.80%	500	8e-141	Tna1p n=3 Tax=Trichomonascaceae TaxID=410830 RepID=A0A167CP40_9ASCO
Q6C031_YARLI	31.32%	479	1e-73	YALI0F28193p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F28193g PE=4 SV=1
A0A0J9X623_GEOCN	30.80%	500	7e-72	Similar to Saccharomyces cerevisiae YGR260W TNA1 High affinity nicotinic acid plasma membrane permease OS=Geotrichum candidum GN=BN980_GECA02s07710g PE=4 SV=1
Q5A896_CANAL	29.25%	523	2e-70	Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_CR01220WA PE=4 SV=1
A0A1E4TA01_9ASCO	30.06%	469	2e-69	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_3223 PE=4 SV=1
A0A1E3PD75_9ASCO	29.27%	509	1e-68	MFS general substrate transporter OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_29178 PE=4 SV=1
TNA1_YEAST	28.46%	534	3e-62	High-affinity nicotinic acid transporter OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TNA1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0293

Protein family membership

Major facilitator superfamily (IPR011701)

Domains and repeats

Domain
99 - 526
Major facilitator superfamily domain (IPR020846)

1 100 200 300 400 500 551

Detailed signature matches

IPR011701

Major facilitator superfamily
1. PF07690 (MFS_1)
  
  115 - 480
  
  Pfam
  PF07690 (MFS_1)
IPR020846

Major facilitator superfamily domain
1. SSF103473 (MFS gene...)
  
  99 - 526
  
  SUPERFAMILY
  SSF103473 (MFS general substrate transporter)
2. cd06174 (MFS)
  
  112 - 514
  
  CDD
  cd06174 (MFS)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

224 - 234

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

292 - 339

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

518 - 551

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

170 - 175

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

1 - 110

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

452 - 462

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)

398 - 403

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.12...

99 - 308

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)

331 - 528

GENE3D
G3DSA:1.20.1250.20 (G3DSA:1.20.1250.20)
NON_CYTOPLASM... (N...)

197 - 201

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

362 - 372

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

426 - 430

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

130 - 148

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

259 - 269

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)

485 - 495

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

340 - 362

TMHMM
TMhelix (TMhelix)

404 - 421

TMHMM
TMhelix (TMhelix)

202 - 224

TMHMM
TMhelix (TMhelix)

176 - 198

TMHMM
TMhelix (TMhelix)

147 - 169

TMHMM
TMhelix (TMhelix)

431 - 450

TMHMM
TMhelix (TMhelix)

110 - 127

TMHMM
TMhelix (TMhelix)

372 - 391

TMHMM
TMhelix (TMhelix)

495 - 517

TMHMM
TMhelix (TMhelix)

463 - 485

TMHMM
TMhelix (TMhelix)

268 - 290

TMHMM
TMhelix (TMhelix)

236 - 258

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

270 - 291

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

496 - 517

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

111 - 129

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

202 - 223

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

149 - 169

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

463 - 484

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

340 - 361

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

373 - 397

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

431 - 451

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

404 - 425

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

176 - 196

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

235 - 258

PHOBIUS
TRANSMEMBRANE (Transmembrane region)

Residue annotation

putative substrate...

126R

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

129I

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

130G

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

131N

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

133K

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

134V

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

152V

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

155F

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

156Y

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

159Y

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

163Q

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

164W

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

165G

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

212E

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

213A

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

216S

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

217P

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

220Y

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

221Y

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

224S

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

236V

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

237G

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

240Q

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

241S

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

247S

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

351T

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

354Q

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

355V

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

358P

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

359I

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

362P

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

376Q

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

379T

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

383Y

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

386A

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

390I

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

438V

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

441V

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

442Y

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

445L

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

449M

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

450T

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

453G

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

465G

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

466Y

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

469I

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

470H

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

473G

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

474M

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

477P

putative substrate translocation pore
126R, 129I, 130G, 131N, 133K, 134V, 152V, 155F, 156Y, 159Y, 163Q, 164W, 165G, 212E, 213A, 216S, 217P, 220Y, 221Y, 224S, 236V, 237G, 240Q, 241S, 247S, 351T, 354Q, 355V, 358P, 359I, 362P, 376Q, 379T, 383Y, 386A, 390I, 438V, 441V, 442Y, 445L, 449M, 450T, 453G, 465G, 466Y, 469I, 470H, 473G, 474M, 477P
CDD
cd06174 (MFS)

Protein sequence

>MCA_01418_1
MHNSQENLDEKLNGVTSVRVIEDSLSSDNSGVFYRPENSDGKNTYTESTIEITNPFPEQHVGPDNEVEYTYDISQLPSDS
EVAKEAIENGGKFTYTRSEVKKLLRQYDKHILTFLCFLYFLSHLDRGNIGNAKVAGMNKDLGITSSQFSLVVSMFYVGYI
VFQWGILLWKVIPPRMFAPWIIIGWGIVSTCCAVIKNWKQLLALRVVLGIFEACFSPGIYYYFSFFYHRSEIAKRVGIFQ
SFSPISSAVSGAIAFGITKHAPSGIEPWRLLFIVEGVPSVLGGLVAFYAIINGPESSRFLTQRQKNIAAVRTLEQAGSVH
RGGRKLNFKEVYETLADFKIWANTAMFFCITLCQVPLPIFLPSIIEGMGYQGIYAQGLTAPPYLVAVAGILTTCYISDKY
LQRAYPISVCLLIASVGYILLSVSHTTGVKYFGLYLAVPGVYSALSIIMTWTGDNQGSDTKRGVGYVVIHVIGMVGPIVG
TFLFPSTEAPHYKKGIWVTTGIVMFCMLFSLVYRAYLVRENRKRDEKYGPVDKNEIRKCNDDTQKEYRYVV

GO term prediction

Biological Process

GO:0055085 transmembrane transport

Molecular Function

None predicted.

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features