Protein
MIA_00763_1
Length
901 amino acids
Browser: contig01:2165032-2167828+
Protein function
| EGGNOG: | 0PFWK | PAB1 | Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN (By similarity) |
|---|---|---|---|
| SGD closest match: | S000000967 | PAB1 | Polyadenylate-binding protein, cytoplasmic and nuclear |
| CGD closest match: | CAL0000195952 | PAB1 | Polyadenylate-binding protein, cytoplasmic and nuclear |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MCA_05813_1 | 46.265% | 415 | 1.56e-113 | MCA_05813_1 |
| PABP_YEAST | 36.336% | 333 | 9.23e-49 | Polyadenylate-binding protein, cytoplasmic and nuclear OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PAB1 PE=1 SV=4 |
| UniRef50_P04147 | 36.336% | 333 | 2.21e-45 | Polyadenylate-binding protein, cytoplasmic and nuclear n=108 Tax=Eukaryota TaxID=2759 RepID=PABP_YEAST |
| PABP_CANAL | 33.934% | 333 | 1.55e-43 | Polyadenylate-binding protein, cytoplasmic and nuclear OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PAB1 PE=3 SV=1 |
| A0A060TBF9_BLAAD | 38.060% | 268 | 2.28e-43 | ARAD1B07238p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B07238g PE=4 SV=1 |
| A0A1E4T9Q8_9ASCO | 30.931% | 333 | 6.08e-41 | Polyadenylate-binding protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_70868 PE=3 SV=1 |
| PABP_YARLI | 36.652% | 221 | 2.41e-40 | Polyadenylate-binding protein, cytoplasmic and nuclear OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=PAB1 PE=3 SV=1 |
| A0A1E3PFY9_9ASCO | 31.884% | 345 | 1.83e-39 | Polyadenylate-binding protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47563 PE=3 SV=1 |
| A0A0J9XBX2_GEOCN | 29.882% | 338 | 9.84e-38 | Polyadenylate-binding protein OS=Geotrichum candidum GN=BN980_GECA08s03145g PE=3 SV=1 |
| A0A167EIC1_9ASCO | 28.255% | 361 | 1.09e-36 | Polyadenylate-binding protein OS=Sugiyamaella lignohabitans GN=PAB1 PE=3 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0126
Protein family membership
None predicted.
Domains and repeats
-
Domain
1
100
200
300
400
500
600
700
800
901
Detailed signature matches
no IPR
Unintegrated signatures
-
-
cd00590 (RRM_SF)
-
cd12378 (RRM1_I_PABPs)
-
mobidb-lite (disord...)
Residue annotation
-
RNA binding site c...
-
oligomer interface...
Protein sequence
>MIA_00763_1 MTSVHYTDLSIAGSTTPAFPKTPVLAPTGSELSSLSSSPLSSETVTSPGFSIDVAKAGDGFTEADVPIGPIAITTITAEA VIDGEYDDDDMPLFSLSNRSLTVATSRSSQKSLDDAPTSDTLVASPGVDRKMGLAKEDFVCVHTLSQENLVEEENEDDDD DDDDKEKEKEEKAENTDCAADSNDGSITSPKLSSFGTYPLYVGDLHPDVTEALLYSVFGVCGSISSVRICRDAMTQTSLG YAYVNFQTKEAAGKALKDLNYSKILGRECRIMPAINRNENQHLPPGSNIYVYHLHPTIESRALYDRFSKYGKVVSCKVVR NVHTGQSMCRGYVQFGTKKDADEAISGENGKMFGGSEIHVDSFVSREERLSTIIAKKAPAGILNVCGISPHCTEAELKKV FGMFGAIHSVYFTLNFNPRFVNGSGGYAIIGGTGWGYVNYYDASAARVARSVLNEVILKGVKLSVMERHDAGFHSDEPLQ FMVVVRTFDKTIMMENIEDMVKDSVPLVEILSTSFKVYPRIEGASVQCATITAQSFDESEAIISGINSPSSPWRSLVACH AGQEATKFRPRYGYYYKHNGELGGSGGDEGRQLRGGKFGRQQYQNQPQAPQQQQQQQRRFDESNNSSNNSGNNNNGGNYH RNESIGRRDYYARRGHYGDNHHHHHHHHHNHQRNWRNKNDDSRPQQIFESEESGEGQLYTGKKQVSLPLKPREELMVGSC AGATRAETAEEGIEEEVAPPKGPAAQQTRSIVGVCTSNTGGNSSMMPATVYGGDAGYFGGWPIVDGSIGAAAVAAAAAAT TGAYYGQYAAMYPHPHHHGYAAYYQYPTQEAYIGFPMSTIGSGVGGGSNNSRGENSSSIGGVPVVGESDISGNVGGGHQL GSGITAILISSSKEVVVSMVG
GO term prediction
Biological Process
None predicted.
Molecular Function
GO:0003676 nucleic acid binding
Cellular Component
None predicted.