Protein
MCA_05813_1
Length
983 amino acids
Gene name: PAB1A
Description: Polyadenylate-binding protein, cytoplasmic and nuclear
Browser: contigD:2403964-2406916+
RNA-seq: read pairs 107, FPKM 1.3, percentile rank 10.2% (100% = highest expression)
Protein function
| Annotation: | PAB1A | Polyadenylate-binding protein, cytoplasmic and nuclear | |
|---|---|---|---|
| KEGG: | K13126 | PABPC | polyadenylate-binding protein |
| EGGNOG: | 0PFWK | PAB1 | Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN (By similarity) |
| SGD closest match: | S000000967 | PAB1 | Polyadenylate-binding protein, cytoplasmic and nuclear |
| CGD closest match: | CAL0000195952 | PAB1 | Polyadenylate-binding protein, cytoplasmic and nuclear |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_00763_1 | 46.99% | 415 | 1e-120 | MIA_00763_1 |
| UniRef50_A0A1Q3ESC1 | 33.02% | 315 | 4e-42 | Polyadenylate-binding protein n=1 Tax=Lentinula edodes TaxID=5353 RepID=A0A1Q3ESC1_LENED |
| A0A060TBF9_BLAAD | 34.50% | 258 | 2e-42 | ARAD1B07238p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B07238g PE=4 SV=1 |
| PABP_YARLI | 30.30% | 396 | 2e-40 | Polyadenylate-binding protein, cytoplasmic and nuclear OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=PAB1 PE=3 SV=1 |
| A0A1E4T9Q8_9ASCO | 31.85% | 292 | 3e-39 | Polyadenylate-binding protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_70868 PE=3 SV=1 |
| A0A1E3PFY9_9ASCO | 32.87% | 289 | 2e-38 | Polyadenylate-binding protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47563 PE=3 SV=1 |
| A0A167EIC1_9ASCO | 31.40% | 293 | 3e-38 | Polyadenylate-binding protein OS=Sugiyamaella lignohabitans GN=PAB1 PE=3 SV=1 |
| PABP_CANAL | 33.22% | 292 | 5e-37 | Polyadenylate-binding protein, cytoplasmic and nuclear OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PAB1 PE=3 SV=1 |
| PABP_YEAST | 33.79% | 293 | 1e-36 | Polyadenylate-binding protein, cytoplasmic and nuclear OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PAB1 PE=1 SV=4 |
| A0A0J9XBX2_GEOCN | 30.03% | 293 | 3e-35 | Polyadenylate-binding protein OS=Geotrichum candidum GN=BN980_GECA08s03145g PE=3 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0110
Protein family membership
None predicted.
Domains and repeats
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Domain
1
100
200
300
400
500
600
700
800
900
983
Detailed signature matches
no IPR
Unintegrated signatures
-
-
cd00590 (RRM_SF)
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cd12378 (RRM1_I_PABPs)
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mobidb-lite (disord...)
Residue annotation
-
RNA binding site c...
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oligomer interface...
Protein sequence
>MCA_05813_1 MESPVCPSDLSLTDINDAGQPKSIAGEIFSPVSTSCGTESRPTSSNFYNSMKTFTADSIDQSEEISLFPVSQSSIGDSDL SASASVSKKDFINCEESEGSFNKEVHKGNVEIITNNPVETVIEPLSTDLKAEIDSKPSSLGDSPSTPEVDFSNASPTSSS TDTQTPETSTGQSTVEPQASNTVSFEQKAKIPEPPVESNVQAGIDATYFAKSFTKKREGNDEIFKKLGDYNANTFAKSSP PPSVFDPAVLSTPTLSSFGTYPLYIGDLDKNVTEALIFSIFSKCGPIASVKICRDATTKMSLGYGYVNFQNKEGAETALR EMNYTKILDVECRIMPSAPHPKEVKFPEGANIYLYNLHSSISARGLYEKFSEYGKIISLKMVRNPHTGKSMCRAYIQYAT KEEADKAIKHQHDRYFGGSRIGVHNFLSKEERKGYYTSKKTPEGILNIRGIAPTANEISLRELFDTFGTIHSVYFTLDTP PKETRLSLGKTIEKNPGTGWGYVNYYDSISAKITKSALHDVYYFGSRLLVDISNSKIFESKSEKRKLEEASLEKTKPNEE QSKGDEATKALDEYPIVIRTFDKKIDMSQIESIIKQLVPDLELPSSLFKVYKRPAGTTLQCTSILARSKEEGDKIVEAIN NNFDQWSSLVACVAGSNAFKSRNRRKLDDDSTKENVLGDANKMLSKRGELSEKDNALKDSTRSLNINSQATKPLSLDNQN STTSDYTGSYSLPDAESISYYYGWPLETAKAYLQYQKQYQQYQKQFSLYSNQANQHEDSTKSGANQTQSNSRTQRNNAVA KNSSSGFNRDYGSGDRRDFGKGNNFQNNNDQKRQQKYQRGNDDDNRSFSNSRTAFNNNNNNNNKSGSRPSLRKSDQKSFV KPDVKRNQPFNNSSKQNQNSRNVNSGYMKKSDNSQVFKTKKGKVYDNPNLTQLGPRPGVSNKQQAESFGNTGSDADKKKK KNKNTANVVTGKESLRMSRYFNN
GO term prediction
Biological Process
None predicted.
Molecular Function
GO:0003676 nucleic acid binding
Cellular Component
None predicted.