MIA_00728_1

Protein

Length

361 amino acids

Browser: contig01:2063526-2064612-

Protein function

EGGNOG:	0PFPK	FDH1	formate dehydrogenase
SGD closest match:	S000005915	FDH1	Formate dehydrogenase 1
CGD closest match:	CAL0000191596	orf19.1117	Formate dehydrogenase

Protein alignments

	%id	Aln length	E-value
MCA_06442_1	86.944%	360	0.0	MCA_06442_1
A0A0J9XCB4_GEOCN	79.501%	361	0.0	Formate dehydrogenase OS=Geotrichum candidum GN=BN980_GECA09s01869g PE=3 SV=1
Q6C009_YARLI	78.116%	361	0.0	Formate dehydrogenase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F28765g PE=3 SV=1
UniRef50_Q6C009	78.116%	361	0.0	Formate dehydrogenase n=5 Tax=Saccharomycetales TaxID=4892 RepID=Q6C009_YARLI
A0A060T0V8_BLAAD	75.556%	360	0.0	Formate dehydrogenase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C15906g PE=3 SV=1
A0A1E4TDG0_9ASCO	71.823%	362	0.0	Formate dehydrogenase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_144271 PE=3 SV=1
FDH1_YEAST	63.003%	373	2.78e-167	Formate dehydrogenase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FDH1 PE=1 SV=1
A0A1D8PNS1_CANAL	60.000%	375	3.18e-159	Formate dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.1117 PE=3 SV=1
A0A167D133_9ASCO	75.685%	292	3.12e-159	Formate dehydrogenase (NAD+) OS=Sugiyamaella lignohabitans GN=FDH1 PE=3 SV=1
A0A1E3PJZ8_9ASCO	33.871%	248	7.61e-30	Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_69982 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0691

Protein family membership

NAD-dependent formate dehydrogenase (IPR033689)

Domains and repeats

Domain
33 - 334
D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain (IPR006139)
Domain
119 - 310
NAD(P)-binding domain (IPR016040)
D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain (IPR006140)

1 50 100 150 200 250 300 361

Detailed signature matches

IPR033689

NAD-dependent formate dehydrogenase
1. cd05302 (FDH)
  
  2 - 354
  
  CDD
  cd05302 (FDH)
2. MF_03210 (Formate_d...)
  
  2 - 356
  
  HAMAP
  MF_03210 (Formate_dehydrogenase)
IPR006139

D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
1. PF00389 (2-Hacid_dh)
  
  33 - 334
  
  Pfam
  PF00389 (2-Hacid_dh)
IPR016040

NAD(P)-binding domain
1. SSF51735 (NAD(P)-bi...)
  
  119 - 310
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR006140

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
1. PF02826 (2-Hacid_dh_C)
  
  125 - 309
  
  Pfam
  PF02826 (2-Hacid_dh_C)
IPR029752

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1
1. PS00065 (D_2_HYDROX...)
  
  164 - 192
  
  PROSITE patterns
  PS00065 (D_2_HYDROXYACID_DH_1)
IPR029753

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site
1. PS00671 (D_2_HYDROX...)
  
  244 - 260
  
  PROSITE patterns
  PS00671 (D_2_HYDROXYACID_DH_3)
2. PS00670 (D_2_HYDROX...)
  
  215 - 237
  
  PROSITE patterns
  PS00670 (D_2_HYDROXYACID_DH_2)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

145 - 311

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)

10 - 144

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
NON_CYTOPLASM... (N...)

16 - 361

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
SIGNAL_PEPTIDE (Sig...)

1 - 15

PHOBIUS
SIGNAL_PEPTIDE (Signal Peptide)
SIGNAL_PEPTID... (S...)

12 - 15

PHOBIUS
SIGNAL_PEPTIDE_C_REGION (Signal peptide C-region)
SIGNAL_PEPTID... (S...)

4 - 11

PHOBIUS
SIGNAL_PEPTIDE_H_REGION (Signal peptide H-region)
SIGNAL_PEPTID... (S...)

1 - 3

PHOBIUS
SIGNAL_PEPTIDE_N_REGION (Signal peptide N-region)
SSF52283 (Formate/g...)

4 - 141

SUPERFAMILY
SSF52283 (Formate/glycerate dehydrogenase catalytic domain-like)
SignalP-noTM

1 - 15

SignalP euk
SignalP-noTM (SignalP-noTM)

Residue annotation

dimerization inter...

9Y

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

10S

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

11A

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

21L

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

118T

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

119S

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

122E

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

123H

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

125V

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

126M

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

129L

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

130V

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

133R

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

135F

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

136V

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

138A

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

139H

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

140D

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

141Q

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

142V

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

143R

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

145G

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

146E

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

147W

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

148D

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

149V

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

150A

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

151A

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

152V

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

153A

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

154K

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

156S

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

157Y

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

158D

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

159I

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

160E

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

162K

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

178E

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

179R

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

182P

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

183F

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

281W

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

284Q

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

285P

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

286A

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

288A

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

293R

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

294T

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

303N

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

304A

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

305M

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

306V

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

307P

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

308H

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

309M

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

310S

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

312T

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

313S

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

314L

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

315D

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

317Q

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)

319R

dimerization interface
9Y, 10S, 11A, 21L, 118T, 119S, 122E, 123H, 125V, 126M, 129L, 130V, 133R, 135F, 136V, 138A, 139H, 140D, 141Q, 142V, 143R, 145G, 146E, 147W, 148D, 149V, 150A, 151A, 152V, 153A, 154K, 156S, 157Y, 158D, 159I, 160E, 162K, 178E, 179R, 182P, 183F, 281W, 284Q, 285P, 286A, 288A, 293R, 294T, 303N, 304A, 305M, 306V, 307P, 308H, 309M, 310S, 312T, 313S, 314L, 315D, 317Q, 319R
CDD
cd05302 (FDH)
NAD binding site c...

68F

NAD binding site
68F, 92V, 116N, 117V, 120V, 168G, 170G, 171R, 172I, 192D, 193Y, 194Q, 225N, 226T, 227P, 229Y, 232T, 253T, 254A, 255R, 279D, 280V, 308H, 310S, 311G
CDD
cd05302 (FDH)

92V

NAD binding site
68F, 92V, 116N, 117V, 120V, 168G, 170G, 171R, 172I, 192D, 193Y, 194Q, 225N, 226T, 227P, 229Y, 232T, 253T, 254A, 255R, 279D, 280V, 308H, 310S, 311G
CDD
cd05302 (FDH)

116N

NAD binding site
68F, 92V, 116N, 117V, 120V, 168G, 170G, 171R, 172I, 192D, 193Y, 194Q, 225N, 226T, 227P, 229Y, 232T, 253T, 254A, 255R, 279D, 280V, 308H, 310S, 311G
CDD
cd05302 (FDH)

117V

NAD binding site
68F, 92V, 116N, 117V, 120V, 168G, 170G, 171R, 172I, 192D, 193Y, 194Q, 225N, 226T, 227P, 229Y, 232T, 253T, 254A, 255R, 279D, 280V, 308H, 310S, 311G
CDD
cd05302 (FDH)

120V

NAD binding site
68F, 92V, 116N, 117V, 120V, 168G, 170G, 171R, 172I, 192D, 193Y, 194Q, 225N, 226T, 227P, 229Y, 232T, 253T, 254A, 255R, 279D, 280V, 308H, 310S, 311G
CDD
cd05302 (FDH)

168G

NAD binding site
68F, 92V, 116N, 117V, 120V, 168G, 170G, 171R, 172I, 192D, 193Y, 194Q, 225N, 226T, 227P, 229Y, 232T, 253T, 254A, 255R, 279D, 280V, 308H, 310S, 311G
CDD
cd05302 (FDH)

170G

NAD binding site
68F, 92V, 116N, 117V, 120V, 168G, 170G, 171R, 172I, 192D, 193Y, 194Q, 225N, 226T, 227P, 229Y, 232T, 253T, 254A, 255R, 279D, 280V, 308H, 310S, 311G
CDD
cd05302 (FDH)

171R

NAD binding site
68F, 92V, 116N, 117V, 120V, 168G, 170G, 171R, 172I, 192D, 193Y, 194Q, 225N, 226T, 227P, 229Y, 232T, 253T, 254A, 255R, 279D, 280V, 308H, 310S, 311G
CDD
cd05302 (FDH)

172I

NAD binding site
68F, 92V, 116N, 117V, 120V, 168G, 170G, 171R, 172I, 192D, 193Y, 194Q, 225N, 226T, 227P, 229Y, 232T, 253T, 254A, 255R, 279D, 280V, 308H, 310S, 311G
CDD
cd05302 (FDH)

192D

NAD binding site
68F, 92V, 116N, 117V, 120V, 168G, 170G, 171R, 172I, 192D, 193Y, 194Q, 225N, 226T, 227P, 229Y, 232T, 253T, 254A, 255R, 279D, 280V, 308H, 310S, 311G
CDD
cd05302 (FDH)

193Y

NAD binding site
68F, 92V, 116N, 117V, 120V, 168G, 170G, 171R, 172I, 192D, 193Y, 194Q, 225N, 226T, 227P, 229Y, 232T, 253T, 254A, 255R, 279D, 280V, 308H, 310S, 311G
CDD
cd05302 (FDH)

194Q

NAD binding site
68F, 92V, 116N, 117V, 120V, 168G, 170G, 171R, 172I, 192D, 193Y, 194Q, 225N, 226T, 227P, 229Y, 232T, 253T, 254A, 255R, 279D, 280V, 308H, 310S, 311G
CDD
cd05302 (FDH)

225N

NAD binding site
68F, 92V, 116N, 117V, 120V, 168G, 170G, 171R, 172I, 192D, 193Y, 194Q, 225N, 226T, 227P, 229Y, 232T, 253T, 254A, 255R, 279D, 280V, 308H, 310S, 311G
CDD
cd05302 (FDH)

226T

NAD binding site
68F, 92V, 116N, 117V, 120V, 168G, 170G, 171R, 172I, 192D, 193Y, 194Q, 225N, 226T, 227P, 229Y, 232T, 253T, 254A, 255R, 279D, 280V, 308H, 310S, 311G
CDD
cd05302 (FDH)

227P

NAD binding site
68F, 92V, 116N, 117V, 120V, 168G, 170G, 171R, 172I, 192D, 193Y, 194Q, 225N, 226T, 227P, 229Y, 232T, 253T, 254A, 255R, 279D, 280V, 308H, 310S, 311G
CDD
cd05302 (FDH)

229Y

NAD binding site
68F, 92V, 116N, 117V, 120V, 168G, 170G, 171R, 172I, 192D, 193Y, 194Q, 225N, 226T, 227P, 229Y, 232T, 253T, 254A, 255R, 279D, 280V, 308H, 310S, 311G
CDD
cd05302 (FDH)

232T

NAD binding site
68F, 92V, 116N, 117V, 120V, 168G, 170G, 171R, 172I, 192D, 193Y, 194Q, 225N, 226T, 227P, 229Y, 232T, 253T, 254A, 255R, 279D, 280V, 308H, 310S, 311G
CDD
cd05302 (FDH)

253T

NAD binding site
68F, 92V, 116N, 117V, 120V, 168G, 170G, 171R, 172I, 192D, 193Y, 194Q, 225N, 226T, 227P, 229Y, 232T, 253T, 254A, 255R, 279D, 280V, 308H, 310S, 311G
CDD
cd05302 (FDH)

254A

NAD binding site
68F, 92V, 116N, 117V, 120V, 168G, 170G, 171R, 172I, 192D, 193Y, 194Q, 225N, 226T, 227P, 229Y, 232T, 253T, 254A, 255R, 279D, 280V, 308H, 310S, 311G
CDD
cd05302 (FDH)

255R

NAD binding site
68F, 92V, 116N, 117V, 120V, 168G, 170G, 171R, 172I, 192D, 193Y, 194Q, 225N, 226T, 227P, 229Y, 232T, 253T, 254A, 255R, 279D, 280V, 308H, 310S, 311G
CDD
cd05302 (FDH)

279D

NAD binding site
68F, 92V, 116N, 117V, 120V, 168G, 170G, 171R, 172I, 192D, 193Y, 194Q, 225N, 226T, 227P, 229Y, 232T, 253T, 254A, 255R, 279D, 280V, 308H, 310S, 311G
CDD
cd05302 (FDH)

280V

NAD binding site
68F, 92V, 116N, 117V, 120V, 168G, 170G, 171R, 172I, 192D, 193Y, 194Q, 225N, 226T, 227P, 229Y, 232T, 253T, 254A, 255R, 279D, 280V, 308H, 310S, 311G
CDD
cd05302 (FDH)

308H

NAD binding site
68F, 92V, 116N, 117V, 120V, 168G, 170G, 171R, 172I, 192D, 193Y, 194Q, 225N, 226T, 227P, 229Y, 232T, 253T, 254A, 255R, 279D, 280V, 308H, 310S, 311G
CDD
cd05302 (FDH)

310S

NAD binding site
68F, 92V, 116N, 117V, 120V, 168G, 170G, 171R, 172I, 192D, 193Y, 194Q, 225N, 226T, 227P, 229Y, 232T, 253T, 254A, 255R, 279D, 280V, 308H, 310S, 311G
CDD
cd05302 (FDH)

311G

NAD binding site
68F, 92V, 116N, 117V, 120V, 168G, 170G, 171R, 172I, 192D, 193Y, 194Q, 225N, 226T, 227P, 229Y, 232T, 253T, 254A, 255R, 279D, 280V, 308H, 310S, 311G
CDD
cd05302 (FDH)
catalytic site cd0...

255R

catalytic site
255R, 284Q, 308H
CDD
cd05302 (FDH)

284Q

catalytic site
255R, 284Q, 308H
CDD
cd05302 (FDH)

308H

catalytic site
255R, 284Q, 308H
CDD
cd05302 (FDH)

Protein sequence

>MIA_00728_1
MVKILLVLYSAGSHALDEPKLHGCTENELGIRNWLESQGHTLITTDKKDGPEFEKLLEDAEVVITTPFHPAYLTRERLLK
AKKLKLCVTAGVGSDHLDLDTANELKIAVLEVTGSNVTSVAEHAVMTMLVLVRNFVPAHDQVRNGEWDVAAVAKDSYDIE
GKVIATVGVGRIGSRILERLKPFNPKELLYYDYQPLSADREREIGCRRVESLEEMLGQADIVTINTPLYESTKGLFNKNL
LSKMKRGAWLVNTARGAICVQEDVVEALESGQLRGYGGDVWFPQPAPADHPWRTMTNKYGAGNAMVPHMSGTSLDAQQRY
ANGVKNILESYFSGKFDYRPQDIIVIDGHYGTKAYGEDKKT

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0008863 formate dehydrogenase (NAD+) activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding

Cellular Component

None predicted.

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Entry type

Status

Per-residue features