Protein

MCA_06442_1

Length
363 amino acids


Gene name: FDH1

Description: Formate dehydrogenase 1

Browser: contigD:4241511-4242603-

RNA-seq: read pairs 166362, FPKM 5647.2, percentile rank 99.7% (100% = highest expression)

Protein function

Annotation:FDH1Formate dehydrogenase 1
KEGG:K00122FDH formate dehydrogenase [EC:1.2.1.2]
EGGNOG:0PFPKFDH1formate dehydrogenase
SGD closest match:S000005915FDH1Formate dehydrogenase 1
CGD closest match:CAL0000180074FDH1Formate dehydrogenase

Protein alignments

%idAln lengthE-value
MIA_00728_186.94%3600.0MIA_00728_1
A0A0J9XCB4_GEOCN78.61%3600.0Formate dehydrogenase OS=Geotrichum candidum GN=BN980_GECA09s01869g PE=3 SV=1
Q6CDN8_YARLI75.35%3610.0Formate dehydrogenase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B22506g PE=3 SV=1
UniRef50_Q6C00973.89%3600.0Formate dehydrogenase n=5 Tax=Saccharomycetales TaxID=4892 RepID=Q6C009_YARLI
A0A060T0V8_BLAAD76.04%3590.0Formate dehydrogenase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C15906g PE=3 SV=1
A0A1E4TDG0_9ASCO71.63%3630.0Formate dehydrogenase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_144271 PE=3 SV=1
FDH1_YEAST63.81%3737e-167Formate dehydrogenase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FDH1 PE=1 SV=1
A0A167D133_9ASCO76.29%2912e-158Formate dehydrogenase (NAD+) OS=Sugiyamaella lignohabitans GN=FDH1 PE=3 SV=1
Q59QN6_CANAL60.27%3753e-152Formate dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=FDH1 PE=3 SV=1
A0A1E3PJZ8_9ASCO34.01%2474e-31Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_69982 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0205

Protein family membership

Domains and repeats

1 50 100 150 200 250 300 363

Detailed signature matches

    1. cd05302 (FDH)
    2. MF_03210 (Formate_d...)
    1. PF00389 (2-Hacid_dh)
    1. SSF51735 (NAD(P)-bi...)
    1. PF02826 (2-Hacid_dh_C)
    1. PS00065 (D_2_HYDROX...)
    1. PS00671 (D_2_HYDROX...)
    2. PS00670 (D_2_HYDROX...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. SSF52283 (Formate/g...)

Residue annotation

  1. dimerization inter...
  2. NAD binding site c...
  3. catalytic site cd0...

Protein sequence

>MCA_06442_1
MAKILLVLYSAGSHAEDEPQLLGCTENALGIQDWLESQGHELIITSFKDGPEFEALLSDVEIIITTPFHPAYLTRERLLK
AKKLKLCVTAGVGSDHVDLATANELKIGVLEVTGSNVVSVAEHAVMTMLVLVRNFVPAHDQIRNGEWDVAGVAKDSYDIE
GKVIATVGVGRIGSRILERLKPFNPKELLYYDYQPLSKEQEEKIGCRRVTDLEEMLGQADIVTINCPLHESTRGLFNKKL
ISKMKRGAWLVNTARGAICVKEDVAEALKSGQLRGYGGDVWFPQPAPADHPWRTMTNKYGFGNAMVPHMSGTTLDAQQRY
ATGVKNILESYFSGKKDYRPQDVIVIDGHYASRSYGDDKKVHQ

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0008863 formate dehydrogenase (NAD+) activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding

Cellular Component

None predicted.