Protein

MIA_00721_1

Length
468 amino acids

Browser: contig01:2050632-2052039+

Protein function

EGGNOG:0PJ1FRAD18E3 RING-finger protein, member of the UBC2 RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2 RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA
SGD closest match:S000000662RAD18Postreplication repair E3 ubiquitin-protein ligase RAD18
CGD closest match:CAL0000182971RAD18Postreplication repair E3 ubiquitin-protein ligase RAD18

Protein alignments

%idAln lengthE-value
MCA_05937_137.461%3234.67e-64MCA_05937_1
A0A0J9XIQ8_GEOCN29.851%3352.72e-40Similar to Saccharomyces cerevisiae YCR066W RAD18 E3 ubiqutin ligase OS=Geotrichum candidum GN=BN980_GECA17s01110g PE=4 SV=1
UniRef50_W6MM1329.012%3242.16e-33Uncharacterized protein n=1 Tax=Kuraishia capsulata CBS 1993 TaxID=1382522 RepID=W6MM13_9ASCO
RAD18_YEAST27.195%3533.49e-30Postreplication repair E3 ubiquitin-protein ligase RAD18 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RAD18 PE=1 SV=1
RAD18_CANAL27.401%3545.04e-29Postreplication repair E3 ubiquitin-protein ligase RAD18 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=RAD18 PE=3 SV=2
A0A060T995_BLAAD25.542%4158.61e-28ARAD1C42284p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C42284g PE=4 SV=1
RAD18_YARLI26.814%3174.06e-24Postreplication repair E3 ubiquitin-protein ligase RAD18 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=RAD18 PE=3 SV=1
A0A1E3PDZ3_9ASCO33.708%1785.37e-21Uncharacterized protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_8231 PE=4 SV=1
A0A1E4TC30_9ASCO47.368%571.58e-12Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_3829 PE=4 SV=1
A0A167DZN3_9ASCO31.333%1503.04e-09E3 ubiquitin-protein ligase RAD18 OS=Sugiyamaella lignohabitans GN=RAD18 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0195

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 468

Detailed signature matches

  1. Family IPR004580
    DNA repair protein, Rad18
    1. TIGR00599
  2. Domain IPR013083
    Zinc finger, RING/FYVE/PHD-type
    1. G3DSA:3.30.40.10
  3. Domain IPR001841
    Zinc finger, RING-type
    1. SM00184 (ring_2)
    2. PS50089 (ZF_RING_2)
  4. SITE IPR017907
    Zinc finger, RING-type, conserved site
    1. PS00518 (ZF_RING_1)
Unintegrated signatures no IPR
Unintegrated signatures
  1. PF13923 (zf-C3HC4_2)
  2. SSF57850 (RING/U-box)
  3. cd16529 (RING-HC_RAD18)
  4. mobidb-lite (disord...)

Residue annotation

  1. Zn binding site cd...
  2. homodimer interfac...

Protein sequence

>MIA_00721_1
MTLHNITHSTEWLGTEIPEMAEMDEALRCDICKELMIAPVMTGCSHTFCSLCIRRVLVAEQKCPTCRHSASESQLRRNGS
VEMCLEVFSKVRSRLLDLTRRKESDEDDLPNKDKSEKSSVTIPTEGLQPVNGETCDGETQQDQTLSPPRSPQQQEPESNP
KKIPLQIPDQHAPCPVCNKVLPIKEIQSTHISECLSGASTSGSDTSCKRTVSLPRTRSSVNSIASHQATILTASNDHSSN
NNSTPSLFTVRTRRQARLAKTEDMNVKLPRNNDWNLSVSKLRARLTRLGIPSHGAGRQDLLKRETEWITIWNANADRKDP
LPRAKLLQQLAEWEEAERLSKSQRSLSMQQSSSSSLSTSEVPVVNSVRLSPSKKNNKSVTEGDTKPPIPFIPTDLKSLNR
DLYSRSHDASFRELTAQARASLKRKAAQAIGGTGVVATGKENESNDGANKKQKKEDETQAGPAVEQAA

GO term prediction

Biological Process

GO:0006281 DNA repair

Molecular Function

GO:0003684 damaged DNA binding

Cellular Component

GO:0005634 nucleus