Protein
MIA_00695_1
Length
984 amino acids
Browser: contig01:1997102-2000057-
Protein function
| EGGNOG: | 0PM24 | SIN4 | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity) |
|---|---|---|---|
| SGD closest match: | S000005180 | SIN4 | Mediator of RNA polymerase II transcription subunit 16 |
| CGD closest match: | CAL0000174522 | SIN4 | Mediator of RNA polymerase II transcription subunit 16 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| A0A0J9X2N3_GEOCN | 33.94% | 984 | 3e-174 | Similar to Saccharomyces cerevisiae YNL236W SIN4 Subunit of the RNA polymerase II mediator complex OS=Geotrichum candidum GN=BN980_GECA01s08221g PE=4 SV=1 |
| UniRef50_A0A0J9X2N3 | 33.94% | 984 | 7e-171 | Similar to Saccharomyces cerevisiae YNL236W SIN4 Subunit of the RNA polymerase II mediator complex n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X2N3_GEOCN |
| MCA_05927_1 | 37.72% | 851 | 2e-163 | MCA_05927_1 |
| A0A060TD79_BLAAD | 28.86% | 887 | 7e-97 | ARAD1D45826p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D45826g PE=4 SV=1 |
| A0A1E3PHM4_9ASCO | 28.09% | 833 | 6e-73 | Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_66043 PE=4 SV=1 |
| MED16_YARLI | 27.12% | 848 | 5e-65 | Mediator of RNA polymerase II transcription subunit 16 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=SIN4 PE=3 SV=1 |
| A0A167F9N4_9ASCO | 27.14% | 667 | 1e-59 | Sin4p OS=Sugiyamaella lignohabitans GN=SIN4 PE=4 SV=1 |
| A0A1E4TKQ7_9ASCO | 23.20% | 862 | 3e-36 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_891 PE=4 SV=1 |
| MED16_CANAL | 23.92% | 301 | 1e-12 | Mediator of RNA polymerase II transcription subunit 16 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SIN4 PE=3 SV=2 |
| MED16_YEAST | 20.20% | 683 | 1e-10 | Mediator of RNA polymerase II transcription subunit 16 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SIN4 PE=1 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0979
Predicted cleavage: 30
Protein family membership
- Mediator complex, subunit Med16 (IPR021665)
Domains and repeats
-
Domain
1
100
200
300
400
500
600
700
800
900
984
Detailed signature matches
-
-
PF11635 (Med16)
-
no IPR
Unintegrated signatures
-
mobidb-lite (disord...)
Protein sequence
>MIA_00695_1 MGAAPYFQSHLGNQLRTGCNNRIAWAPRTGTIAHVVDKSVVHITNLVCLDGESWGFSKPFKIYPTAPSGQVIDIPHLSWS SSGTDLAVADEHGTLNIYMQSYTELGVMNRIFQSSPPESNAGPAEMNKIIGFKWFDQKSNHNISIFNPPVVQNHVQKFVY TLDRSALGGSSYIADISSYSMPMPGPLVPLNKHSCIAFTRRGMVRLFTQGVSDTKYYEFSCSADRDSMTRESVVFSHASF SSTADGSVILSAYSSETECIYFYRIFVEWPALTAAAAAASGIKSQLKSGSNQLSTLKIQRILRQKLIPALNPSLTLSHIH LMPSGPQNFRGAEVELRVAFTNKTSTIIQKYFLIKYKPPILKPFASLSSRSDYGGGDLVGTETATLFVTDDLSLYPKLAI SIGSSNYDTIFNVSFSDGTTDLRFRTQYSKLPPTSASMQTIMLSGFQFLDLPEPITDICVSHNTCSALYLTQNNEIRISY ARNLKLLVPPKQPDKSYKKPLYLTLAAVTLAVRHAMAITANHHTDDLYVVMKLVEEDLKRVSPKLADEFIHILILESYRA INFPLDNLILKEGDYKELLQQLFSKMFTLQTVLGTSKGWKRSPMARVSWATQSIRTVFIAIFMTTQQLTQISKNQKQMHE QQNTPFDASDYEEREKCIEPIVGIIRYIVDLFVFIFQDLYLASLEPVDKYYEYFQNKNSVAMSLLLSRLPRAFLCLTLRF FRNIQDNLKQMIEEGSKAPDSASQRASKQIVSIIQANSPINITHFEAILRETNSLMEKIIPKMKNRIVIEDSVFLSVSPP KELAMVVNRIVSLFSKLDKTTMNAAWLYYYDVSWLGLNDDNDEEEESNLLLDKTENQSSPSSNGSAETDESKGPSASANS TASNNSVFLPSVKDFSNYDGSKKIRPVHPHMKELRHGIEIDVVMKKEISNAPFAFANSGGTRARCSRCGELTTWKSQRSS SQQTWELMFVKSCPCGGSWISADY
GO term prediction
Biological Process
None predicted.
Molecular Function
GO:0005515 protein binding
Cellular Component
None predicted.