Protein
MCA_05927_1
Length
1,008 amino acids
Gene name: SIN4
Description: Mediator of RNA polymerase II transcription subunit 16
Browser: contigD:2784241-2787268+
RNA-seq: read pairs 1367, FPKM 16.7, percentile rank 36.6% (100% = highest expression)
Protein function
| Annotation: | SIN4 | Mediator of RNA polymerase II transcription subunit 16 | |
|---|---|---|---|
| KEGG: | K15160 | SIN4 | mediator of RNA polymerase II transcription subunit 16, fungi type |
| EGGNOG: | 0PM24 | SIN4 | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity) |
| CGD closest match: | CAL0000174522 | SIN4 | Mediator of RNA polymerase II transcription subunit 16 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_00695_1 | 35.78% | 1034 | 0.0 | MIA_00695_1 |
| A0A0J9X2N3_GEOCN | 33.40% | 1024 | 2e-176 | Similar to Saccharomyces cerevisiae YNL236W SIN4 Subunit of the RNA polymerase II mediator complex OS=Geotrichum candidum GN=BN980_GECA01s08221g PE=4 SV=1 |
| UniRef50_A0A0J9X2N3 | 33.40% | 1024 | 5e-173 | Similar to Saccharomyces cerevisiae YNL236W SIN4 Subunit of the RNA polymerase II mediator complex n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X2N3_GEOCN |
| A0A060TD79_BLAAD | 29.33% | 883 | 2e-101 | ARAD1D45826p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D45826g PE=4 SV=1 |
| A0A1E3PHM4_9ASCO | 27.37% | 833 | 3e-80 | Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_66043 PE=4 SV=1 |
| MED16_YARLI | 25.98% | 843 | 2e-68 | Mediator of RNA polymerase II transcription subunit 16 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=SIN4 PE=3 SV=1 |
| A0A167F9N4_9ASCO | 27.14% | 700 | 3e-66 | Sin4p OS=Sugiyamaella lignohabitans GN=SIN4 PE=4 SV=1 |
| A0A1E4TKQ7_9ASCO | 23.30% | 867 | 3e-36 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_891 PE=4 SV=1 |
| MED16_CANAL | 21.76% | 455 | 2e-06 | Mediator of RNA polymerase II transcription subunit 16 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SIN4 PE=3 SV=2 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0244
Protein family membership
- Mediator complex, subunit Med16 (IPR021665)
Domains and repeats
-
Domain
1
100
200
300
400
500
600
700
800
900
1008
Detailed signature matches
no IPR
Unintegrated signatures
-
-
-
mobidb-lite (disord...)
Protein sequence
>MCA_05927_1 MTGPVYINSKIADHQRTSCNNRIAWSLKGLIAYVSNDFNVNITHLTCLDGEHWDFSGPFKIKPQTVIKSAAPISYLSWSP LGTDLACADEHGNVSIYSTNSPSELGSMQCLFQSNQSATLEPYETNKIIGFKWFDVDNPINMANPPVISQQKFQQAVARQ SLSYTPDTSPVAIYTTTATSQNGPHIPIITGKMKQSCIALTQRGNIKLFCQGVSDFRYFEIPTQLDSDEKTHESTIFSHA SFAGTANNTLLLAAYSSRTETIYLYELNVSWPALEAFINPAKKLAGESNSLGSVKVKRLTRQKLTPQINPSFYLSHIHLL PAGPKGVNAHFDAEAFFIFSSKTQSMHRRYLIGRRKSTLHPNLFTLNSRNDAQSQRPSDRYTTSLVPTQDAATYNKLVVS LGSLNFDSQIYICFADGSVEVKFRHQYVSGKISGSPLLQGIFQAGFVFPTVEFASDVCLSHNLCSALYLDKEGQLCINYI RNNKISMGMAGPKGSREIRKPNVVYLLLSAITLAARYSLTLNTLYYCGDDLFAVMKLAIRDVEKTSPVMGPVLLRWIMRE SYHAARITFERPPSSENNNSISNQNLGRVLILQTCLGTEYGWKRTAMGRIAWASISLRTLGFGFSFTSKEIENTHKNKNA NNDPVNELNIVSEYFMSILGMARTLVDMIAFICQDLYMASIEENYTEYYMGKQSVAMSLLLSRIPRKLLMMTVSALKSLE NKANNYSDIAKQYEHKKFINTYRLIRDVIQIFVPVPFEAFERILTHVERAMEVMHNENKHFSFVEEELTITGVISPALKP VVQSTIELFMSKILDRINVPWLYYYDVSWLGLNDDYQDSTKSSAGHSSEPGAERNGNTEANGNSPANPSITSPLATTSGS PNPISSPLNTNHAQLANINNNNNNNNNSNNEQTHNTTSDAKTHNNSTTKKKKYVSLHPHPAALRAGKEIDYLLKEQIPLV LTDGTRCRCVRCGEVSVWHPFKRLKTPLWVIMFHNTCICEGAWIPADY
GO term prediction
Biological Process
None predicted.
Molecular Function
GO:0005515 protein binding
Cellular Component
None predicted.