Protein

MIA_00663_1

Length
526 amino acids

Browser: contig01:1896346-1897927-

Protein function

EGGNOG:0PHE2FG02466.1Member of the Sir2 family of NAD( )-dependent protein deacetylases
SGD closest match:S000005551HST3NAD-dependent histone deacetylase HST3
CGD closest match:CAL0000186930HST3NAD-dependent histone deacetylase HST3

Protein alignments

%idAln lengthE-value
MCA_00443_154.220%3912.57e-141MCA_00443_1
A0A0J9XCY3_GEOCN55.193%3372.94e-122Similar to Saccharomyces cerevisiae YOR025W HST3 Member of the Sir2 family of NAD(+)-dependent protein deacetylases OS=Geotrichum candidum GN=BN980_GECA10s00417g PE=4 SV=1
UniRef50_A0A0J9XCY355.193%3376.01e-119Similar to Saccharomyces cerevisiae YOR025W HST3 Member of the Sir2 family of NAD(+)-dependent protein deacetylases n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XCY3_GEOCN
A0A1E3PPR1_9ASCO53.333%3302.00e-111NAD-dependent deacetylase HST3 (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_7079 PE=4 SV=1
A0A060T7M4_BLAAD49.394%3301.36e-100ARAD1D00616p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D00616g PE=4 SV=1
A0A1E4TME4_9ASCO48.910%3212.88e-97Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_19658 PE=4 SV=1
HST3_CANAL46.269%3357.62e-90NAD-dependent histone deacetylase HST3 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HST3 PE=3 SV=2
HST3_YEAST43.323%3372.69e-81NAD-dependent histone deacetylase HST3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HST3 PE=1 SV=1
A0A167CKU0_9ASCO36.935%3981.32e-61Hst3p OS=Sugiyamaella lignohabitans GN=HST3 PE=4 SV=1
Q6CAJ8_YARLI35.440%3649.32e-57YALI0D02145p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D02145g PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0831

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 450 500 526

Detailed signature matches

  1. Family IPR003000
    Sirtuin family
    1. PF02146 (SIR2)
  2. Domain IPR029035
    DHS-like NAD/FAD-binding domain
    1. SSF52467 (DHS-like ...)
    2. G3DSA:3.40.50...
  3. Domain IPR026590
    Sirtuin family, catalytic core domain
    1. PS50305 (SIRTUIN)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil

Protein sequence

>MIA_00663_1
MTIKLDPSNLKSWDHLSREERMHLEAIARSISQSKKVITVTGAGISCNAGIPDFRSKDGLYNMVKQQHPNTVVKGKDLFD
VVLFGDEATTSVFFTFMAQLRKCTVAANPTPTHKFLRLLKDKKKLLRCYTQNIDGLEGKIGLTMGGSKPLEQPTTSTGKL
PKDRSKKLTKAALLKQIDVVQLHGDIHSLKCGICNSVFGWTESYEKLCYCGESPSCPSCEEKNSLRQARGMRHSNVGNLR
PNIVLYGEEHPYGDLIGTCVSKDALSRPDVMLIIGTSMKVVGLKKLIKDVAKAVKHPATPRKKKGIVVLINKTDVGLSGF
EDVIDYHIKSDCDDWVMDLKTRIPNLFSIQTTLEKYAVPSINCETVIRDEVCSADSKDICAIDEITLVSPDTPIKQTVQM
ENVMLPTPPTSVCKLTNPRTRSEMRQQNADPYFAMTNSTSMFLSPPATPVVQQKGSVKFDVREDIETGLLINEKAASRNT
RLLNEWSKRPLSKEKVDDVYSEKGARKRKSSLEDVCVPVNRNKRKR

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0070403 NAD+ binding

Cellular Component

None predicted.