Protein

MCA_00443_1

Length
637 amino acids

Gene name: HST3

Description: NAD-dependent histone deacetylase HST3; Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism

Browser: contigA:1411271-1413185-

RNA-seq: read pairs 260, FPKM 5.0, percentile rank 17.4% (100% = highest expression)

Protein function

Annotation:HST3NAD-dependent histone deacetylase HST3; Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
KEGG:K11121SIR2 NAD-dependent histone deacetylase SIR2 [EC:3.5.1.-]
EGGNOG:0PHE2FG02466.1Member of the Sir2 family of NAD( )-dependent protein deacetylases
SGD closest match:S000005551HST3NAD-dependent histone deacetylase HST3
CGD closest match:CAL0000186930HST3NAD-dependent histone deacetylase HST3

Protein alignments

%idAln lengthE-value
MIA_00663_154.22%3911e-139MIA_00663_1
A0A0J9XCY3_GEOCN50.00%3527e-116Similar to Saccharomyces cerevisiae YOR025W HST3 Member of the Sir2 family of NAD(+)-dependent protein deacetylases OS=Geotrichum candidum GN=BN980_GECA10s00417g PE=4 SV=1
UniRef50_A0A0J9XCY350.00%3521e-112Similar to Saccharomyces cerevisiae YOR025W HST3 Member of the Sir2 family of NAD(+)-dependent protein deacetylases n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XCY3_GEOCN
A0A1E3PPR1_9ASCO50.77%3254e-116NAD-dependent deacetylase HST3 (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_7079 PE=4 SV=1
A0A060T7M4_BLAAD48.34%3313e-111ARAD1D00616p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D00616g PE=4 SV=1
HST3_CANAL45.26%3278e-97NAD-dependent histone deacetylase HST3 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HST3 PE=3 SV=2
A0A1E4TME4_9ASCO43.35%3165e-93Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_19658 PE=4 SV=1
HST3_YEAST40.05%3772e-81NAD-dependent histone deacetylase HST3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HST3 PE=1 SV=1
A0A167CKU0_9ASCO46.72%2597e-71Hst3p OS=Sugiyamaella lignohabitans GN=HST3 PE=4 SV=1
Q6CAJ8_YARLI33.05%3572e-58YALI0D02145p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D02145g PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0254

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 637

Detailed signature matches

  1. Family IPR003000
    Sirtuin family
    1. PF02146 (SIR2)
  2. Domain IPR029035
    DHS-like NAD/FAD-binding domain
    1. SSF52467 (DHS-like ...)
    2. G3DSA:3.40.50...
  3. Domain IPR026590
    Sirtuin family, catalytic core domain
    1. PS50305 (SIRTUIN)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. mobidb-lite (disord...)

Protein sequence

>MCA_00443_1
MTIKIDISQLKQWKQLSKEDNKHLDSIAHKLCKSKKVIVVTGAGISCNAGIPDFRSKDGLYNMIKEKYPNVVVQGKDLFD
TVLFNDSQSISIFFTFMAQLRKYTLKATPTQTHRFIRLLKDQQKLIRCYTQNIDGLESREGLKTKPDPETETQVSKVASR
KKLNNKRSLGIYNQVDLVQLHGDINILKCGLCLTEFEWNPDYEKTCLDGEAPSCPSCTAKDEARKAMGMRSRQVGALRPN
IVLYGEEHPEGEAIGKLISRDSRTRPEVLLIIGTSLKVIGLRKLVKDISQTIQKNKKKNSVVVLITQSDLGLSSWDDLID
YHIKCDCDEWVRDLKMRVPDLFKLQTKISDFSTVKLEEIKPGHSSTAENDAQAITTVEETALTNDLNSNCTKKRFSDKIV
GKNPAKSTNTTKILSDIRTEEKCDKNKAFSATDSIKLVKEDDSEKENVKVGTKDIPQTPKKQKAPSAYGHNTVTPSRITR
SRTKASYDAMFPPTPLATPRSQKNLTNLDIDISSCDCIPVSMDSNNTDSIKQNSSKPKLLESTLLPATPPKFNNNLLTPE
QTPKSEIKNIFTELPSVEVTRKAQDKFLEKINLLRGKSGLDKAGTTPSNKRKNTLEEISENSGLVTIHKRKRSSKVA

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0070403 NAD+ binding

Cellular Component

None predicted.