Protein

MIA_00658_1

Length
886 amino acids

Browser: contig01:1877337-1880054-

Protein function

EGGNOG:0PH9RGEF1Chloride channel
SGD closest match:S000003801GEF1Anion/proton exchange transporter GEF1
CGD closest match:CAL0000193105orf19.5880Uncharacterized protein

Protein alignments

%idAln lengthE-value
MCA_00454_168.734%7740.0MCA_00454_1
A0A0J9XF10_GEOCN71.056%7670.0Chloride channel protein OS=Geotrichum candidum GN=BN980_GECA12s03904g PE=3 SV=1
UniRef50_A0A0J9XF1071.056%7670.0Chloride channel protein n=26 Tax=Ascomycota TaxID=4890 RepID=A0A0J9XF10_GEOCN
Q6CI00_YARLI53.737%7760.0Chloride channel protein OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A02959g PE=3 SV=1
A0A167BWV0_9ASCO51.377%8350.0Chloride channel protein OS=Sugiyamaella lignohabitans GN=GEF1 PE=3 SV=1
A0A1E3PQB2_9ASCO50.453%7730.0Chloride channel protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_32096 PE=3 SV=1
A0A060TGG8_BLAAD51.562%7680.0Chloride channel protein OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D30404g PE=3 SV=1
A0A1D8PJZ9_CANAL48.124%7730.0Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.5880 PE=4 SV=1
A0A1E4TI38_9ASCO46.622%7400.0Chloride channel protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_3125 PE=3 SV=1
GEF1_YEAST38.005%7927.44e-132Anion/proton exchange transporter GEF1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GEF1 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2757
Predicted cleavage: 11

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 800 886

Detailed signature matches

  1. Family IPR001807
    Chloride channel, voltage gated
    1. PR00762 (CLCHANNEL)
    2. PF00654 (Voltage_CLC)
  2. Domain IPR014743
    Chloride channel, core
    1. SSF81340 (Clc chlor...)
    2. G3DSA:1.10.30...
  3. Domain IPR000644
    CBS domain
    1. PS51371 (CBS)
    2. SM00116 (cbs_1)
    3. PF00571 (CBS)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. G3DSA:3.10.58...
  3. NON_CYTOPLASM... (N...)
  4. SSF54631 (CBS-domai...)
  5. TMhelix
  6. TRANSMEMBRANE (Tran...)
  7. cd03684 (ClC_3_like)
  8. cd04591 (CBS_pair_E...)
  9. mobidb-lite (disord...)

Residue annotation

  1. putative Cl- selec...
  2. putative pore gati...
  3. putative H+/Cl- co...

Protein sequence

>MIA_00658_1
MVNSSRHKRVHSNASGVSNAFSLASFDSFSSDLSHDGLLSNENASSSSAYNPGHTGPETHNISIDLKDIDEIRRYEDFST
IDWVEDAARENLKRRLKIKRLRERARQNPRNLESGTRRRDYKSRAFSFLFDSLSAAQAWIVLSIIGCVLGALAGSVNIIT
EWLSNLRTGHCTLGIYLNQEFCCPGGQESCAEWKSWTGFVVTDYFTYIFFSTIFAFTAAYLVKVYAPYAAGSGISEIKCI
IAGFVMNGFLEFPTLAIKSLALPLTIASGLSVGKEGPSVHYAVCVGNVIGNMFSKYRHNSSKMREILSACTAAGVAVAFG
SPMGGVLFSIEEVASTFQIKTMWRSYFCALISTIVLAGINAFRTGQIVLFSVSYDQDWHFFEIIFFIILGLFGGVFGIFL
SKWNLRAQGFRKKYLASYAIQEAVFLAFITAVFCYFNAILRLDMTESMQILFRECENGFEESFICDKSQRGRVIMSLIYA
IIVRTFFVIISYGAKVPAGIFVPSMAIGAIFGRIVGTVVQSLHDSYPSSSFFAACPPDGPCITPGTYAFLGAGAALSGVL
HITVTVVIIMYELTGALTYIIPTMIVVGVTQAVGDRWGKGGITDQAIWFNGFPFIDTKEEHTFNAPVSRAMARDNLVVFT
ATDMTLAQVEKILDQTTHRGFPIVDKLETKYLLGYIGRSELKYVIQTKRSQGQALSPNAKCYFSSSPFDRNDRHAHISTE
RSSSINTNSDSDGSTIMSISFEKFVNFTPITVRPQVPLETVMEIFSQLGPGVVLVDYQGKLCGLMSRKDILRYQFKVEHI
YAPKERALDRSAAQQVDQKIWETIVWFVSLTYKWIVRAIPTSLLTRLGIGRGYGFVDGNASSGEINLQPSNSSSSLRWQS
ENSVPR

GO term prediction

Biological Process

GO:0006821 chloride transport
GO:0055085 transmembrane transport

Molecular Function

GO:0005216 ion channel activity
GO:0005247 voltage-gated chloride channel activity

Cellular Component

GO:0016020 membrane