Protein

MCA_00454_1

Length
937 amino acids

Gene name: GEF1

Description: Anion/proton exchange transporter GEF1

Browser: contigA:1445623-1448437+

RNA-seq: read pairs 1526, FPKM 20.1, percentile rank 41.6% (100% = highest expression)

Protein function

Annotation:GEF1Anion/proton exchange transporter GEF1
KEGG:K05012CLCN3_4_5 chloride channel 3/4/5
EGGNOG:0PH9RGEF1Chloride channel
SGD closest match:S000003801GEF1Anion/proton exchange transporter GEF1
CGD closest match:CAL0000193105orf19.5880Uncharacterized protein

Protein alignments

%idAln lengthE-value
MIA_00658_161.93%9430.0MIA_00658_1
A0A0J9XF10_GEOCN63.26%7730.0Chloride channel protein OS=Geotrichum candidum GN=BN980_GECA12s03904g PE=3 SV=1
UniRef50_A0A0J9XF1063.26%7730.0Chloride channel protein n=26 Tax=Ascomycota TaxID=4890 RepID=A0A0J9XF10_GEOCN
Q6CI00_YARLI54.00%7130.0Chloride channel protein OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A02959g PE=3 SV=1
A0A167BWV0_9ASCO52.97%7060.0Chloride channel protein OS=Sugiyamaella lignohabitans GN=GEF1 PE=3 SV=1
A0A060TGG8_BLAAD60.60%5710.0Chloride channel protein OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D30404g PE=3 SV=1
A0A1E3PQB2_9ASCO56.09%5990.0Chloride channel protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_32096 PE=3 SV=1
A0A1D8PJZ9_CANAL56.43%5600.0Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.5880 PE=4 SV=1
A0A1E4TI38_9ASCO55.65%5840.0Chloride channel protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_3125 PE=3 SV=1
GEF1_YEAST42.79%6247e-125Anion/proton exchange transporter GEF1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GEF1 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0857

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 800 937

Detailed signature matches

  1. Family IPR001807
    Chloride channel, voltage gated
    1. PR00762 (CLCHANNEL)
    2. PF00654 (Voltage_CLC)
  2. Domain IPR014743
    Chloride channel, core
    1. SSF81340 (Clc chlor...)
    2. G3DSA:1.10.30...
  3. Domain IPR000644
    CBS domain
    1. PS51371 (CBS)
    2. PF00571 (CBS)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. G3DSA:3.10.58...
  3. NON_CYTOPLASM... (N...)
  4. SSF54631 (CBS-domai...)
  5. TMhelix
  6. TRANSMEMBRANE (Tran...)
  7. cd03684 (ClC_3_like)
  8. cd04591 (CBS_pair_E...)
  9. mobidb-lite (disord...)

Residue annotation

  1. putative Cl- selec...
  2. putative pore gati...
  3. putative H+/Cl- co...

Protein sequence

>MCA_00454_1
MAETSRDRSQSNASRLSNPFSLSSFDTDNGVDQSSTFESRRQARPRKDIDLKEIDEVKRYEDFSTIDWVEEAARENLKRR
LKIQRLRELNQFSNDGYYEEEERGHQRSGSFISDTDFVEGIDEGLFDYSEANGGIQLGQLRRKKLRLKKNGSFFQRQKFK
WKTKLSELFSAAQAWIILTLIGCVLGSLAGSVNITTKWLADIKTGHCSVGFYLNKEFCCPGQETCPEWKSWTGFFLTDYF
AYTIISVFFAFTAAYFVKCFAPYAAGSGISEIKCIIAGFVMKGFLGFPTLAIKSLALPLTIASGLSVGKEGPSVHYAVCV
GNVIGSMFEKYRNNSKMREILSACTAAGVATAFGSPMGGVLFSIEEVSSTFQIKTMWRSYFCALVATGVLAGVNAFRTGQ
IVVFSVSYDYDWHFFEIIFFIILGIFGGCFGIFLIKWNLRVQGFRKKYLGNYAIQEVIFLSCITAMVCYFNPILKLDMTE
SMQWLFRECENGFEDQLICDSSKRGYALISLIFAIVIRTVLVIISYGAKVPAGIFVPSMAIGAIFGRIVGTFVEILHDSF
PNSSFFASCPPDGLCITPGTYAFLGAGAALSGVLHITVTVVIIMYELTGALNYIVPTMIVVGITNLIGDRWGKGGITDQA
IWFNGFPFIDTKEEHRFNAPASEAMAKDIVALPATGMTLDQLQTILSETNHSGFPIIEDENSKYLIGYIRKSEIQYVIEN
KRKKGKLSPTAKCYFASAAKTTQRNTIPSGSRNIEVGSSENEDLFSLGDDEEEENNAYVTKHDNNLFNNDTTLSLPTSST
TNLISDNYNESSSSNEINSIDFERFVNFTPIVVSPLVALETVMEIFSHLGPSVVIVEYHGRLCGLMSRKDILRYQFKVEH
TYAPRERELNRTAAEQVDQQVWETIQWIIAAVHEKLEKFLPSWFFNNDRMNRRHFVR

GO term prediction

Biological Process

GO:0006821 chloride transport
GO:0055085 transmembrane transport

Molecular Function

GO:0005216 ion channel activity
GO:0005247 voltage-gated chloride channel activity

Cellular Component

GO:0016020 membrane