Protein

MIA_00619_1

Length
816 amino acids

Browser: contig01:1800537-1803066+

Protein function

EGGNOG:0PGB2KEX1Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity)
SGD closest match:S000003171KEX1Pheromone-processing carboxypeptidase KEX1
CGD closest match:CAL0000182553KEX1Pheromone-processing carboxypeptidase KEX1

Protein alignments

%idAln lengthE-value
MCA_00166_148.520%7770.0MCA_00166_1
A0A060T255_BLAAD40.805%5222.20e-127ARAD1C29150p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C29150g PE=3 SV=1
UniRef50_A0A060T25540.805%5225.43e-124ARAD1C29150p n=1 Tax=Blastobotrys adeninivorans TaxID=409370 RepID=A0A060T255_BLAAD
A0A0J9XAJ3_GEOCN46.899%5169.60e-125Carboxypeptidase OS=Geotrichum candidum GN=BN980_GECA08s00065g PE=3 SV=1
A0A167DBQ6_9ASCO37.500%4565.81e-81Carboxypeptidase OS=Sugiyamaella lignohabitans GN=KEX1 PE=3 SV=1
A0A1E3PNQ6_9ASCO40.283%2837.26e-61Carboxypeptidase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_68983 PE=3 SV=1
KEX1_YARLI36.897%2901.05e-56Pheromone-processing carboxypeptidase KEX1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=KEX1 PE=3 SV=1
A0A1E4TFJ7_9ASCO36.299%2818.56e-56Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_15892 PE=3 SV=1
KEX1_CANAL32.822%3261.79e-52Pheromone-processing carboxypeptidase KEX1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=KEX1 PE=3 SV=1
KEX1_YEAST33.025%3247.81e-49Pheromone-processing carboxypeptidase KEX1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KEX1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0834
Predicted cleavage: 13

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 816

Detailed signature matches

  1. Family IPR001563
    Peptidase S10, serine carboxypeptidase
    1. PF00450 (Peptidase_S10)
    2. PR00724 (CRBOXYPTASEC)
  2. Domain IPR029058
    Alpha/Beta hydrolase fold
    1. SSF53474 (alpha/bet...)
    2. G3DSA:3.40.50...
  3. SITE IPR033124
    Serine carboxypeptidases, histidine active site
    1. PS00560 (CARBOXYPEP...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. NON_CYTOPLASM... (N...)
  3. SIGNAL_PEPTIDE (Sig...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)
  6. SIGNAL_PEPTID... (S...)
  7. SignalP-noTM
  8. TMhelix
  9. TRANSMEMBRANE (Tran...)
  10. mobidb-lite (disord...)

Protein sequence

>MIA_00619_1
MRTNKFLPVWRLSVATALAVFTALAGTVPGAHAMAIPNPDSAESFFNFVAERRDSAPEPEQPNVKSTAQPYVKQPASSYY
VQNLPGLENIPAAKVPTMHAGHIPIRPENDSNLFFWSFEAEFSVTERRKTVLWLNGGPGCSSMDGAMMEIGPFRLQHSSD
KLELNPGSWHQHANLLFVDQPVGTGLSTTSTGSYLHELPEMARDMMTFLERYFEIFPERQNDEYYLAGESFAGQYLPYLA
RAILDKNLNKTSLLMEILKPAPPAAASQKTNTPVSTSSPTVESSAESSSTSSASADATQPSSAAKEKRDSTAPWVDLKAV
VIGNGWIDPPSQYLTYLPFAYQSGLIKHGSDIAATIESKTKRCSEYFETHENDRAGLAIPVCDEVLDGILREMFLATGLK
RTDPNACVNVYDIRLRDTYSSCGMNWPPDLVNVTPYLRRKDVLSALHVPDSHGWRECSGAVGSAFKAKHSNPSIKILPTL
IEDNIEVVMFNGDQDLICNHVGNEKLIQSLSWGQQQKLGLFAREDEILAQVSGVSSGFTSDEPSLDWFVNGTAAGTIQTG
RNLTYIKVFNASHMVPVDVPEVAQAMINQIMGVPGYSRAEQQPKPTSNIATTDKEDDENTENKGDFGDDNYDSSNPTVPE
DQSGESDNSEEEQETWTPYYKAGAFALVVVAFVAVMLGLFVWRNRRLTRDALSLNGMPARRGVHYEDELEDYEAQRHAPV
REEGFFASILSGISRWHVPTRGGRSLRLKHKTNDPVAGKYRNLGSNAPAGASSIGLAEFHDEDENGDVPLEPINKRDSVD
SILDELSEEPSSHVNK

GO term prediction

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0004185 serine-type carboxypeptidase activity

Cellular Component

None predicted.