Protein

MCA_00166_1

Length
811 amino acids

Gene name: KEX1

Description: Pheromone-processing carboxypeptidase KEX1

Browser: contigA:451192-454196-

RNA-seq: read pairs 5362, FPKM 81.6, percentile rank 75.6% (100% = highest expression)

Protein function

Annotation:KEX1Pheromone-processing carboxypeptidase KEX1
KEGG:K01288KEX1 carboxypeptidase D [EC:3.4.16.6]
EGGNOG:0PGB2KEX1Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity)
SGD closest match:S000003171KEX1Pheromone-processing carboxypeptidase KEX1
CGD closest match:CAL0000182553KEX1Pheromone-processing carboxypeptidase KEX1

Protein alignments

%idAln lengthE-value
MIA_00619_148.20%7760.0MIA_00619_1
A0A060T255_BLAAD40.92%5231e-123ARAD1C29150p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C29150g PE=3 SV=1
UniRef50_A0A060T25540.92%5233e-120ARAD1C29150p n=1 Tax=Blastobotrys adeninivorans TaxID=409370 RepID=A0A060T255_BLAAD
A0A167DBQ6_9ASCO46.49%4417e-122Carboxypeptidase OS=Sugiyamaella lignohabitans GN=KEX1 PE=3 SV=1
A0A0J9XAJ3_GEOCN47.04%4236e-105Carboxypeptidase OS=Geotrichum candidum GN=BN980_GECA08s00065g PE=3 SV=1
A0A1E3PNQ6_9ASCO38.14%3123e-56Carboxypeptidase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_68983 PE=3 SV=1
KEX1_YARLI51.19%1682e-51Pheromone-processing carboxypeptidase KEX1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=KEX1 PE=3 SV=1
KEX1_CANAL48.37%1844e-49Pheromone-processing carboxypeptidase KEX1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=KEX1 PE=3 SV=1
A0A1E4TFJ7_9ASCO37.68%2763e-49Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_15892 PE=3 SV=1
KEX1_YEAST37.32%2841e-45Pheromone-processing carboxypeptidase KEX1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KEX1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1247
Predicted cleavage: 41

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 811

Detailed signature matches

  1. Family IPR001563
    Peptidase S10, serine carboxypeptidase
    1. PF00450 (Peptidase_S10)
    2. PR00724 (CRBOXYPTASEC)
  2. Domain IPR029058
    Alpha/Beta hydrolase fold
    1. SSF53474 (alpha/bet...)
    2. G3DSA:3.40.50...
  3. Domain IPR011989
    Armadillo-like helical
    1. G3DSA:1.25.10.10
  4. SITE IPR018202
    Serine carboxypeptidase, serine active site
    1. PS00131 (CARBOXYPEP...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. Coil
  3. NON_CYTOPLASM... (N...)
  4. SIGNAL_PEPTIDE (Sig...)
  5. SIGNAL_PEPTID... (S...)
  6. SIGNAL_PEPTID... (S...)
  7. SIGNAL_PEPTID... (S...)
  8. SignalP-TM
  9. TMhelix
  10. TRANSMEMBRANE (Tran...)
  11. mobidb-lite (disord...)

Protein sequence

>MCA_00166_1
MITNNIKTRLPFFNNIVVLSLLLLLLTPLSSLATPVSLRQRAENLPGLDLGTSKSASQYHVRNLPGSENLEGQMPTMHAG
HITINETHNSKLFFWSFDAEDPLPGKQKTVLWLNGGPGCSSMDGALMEIGPLRVNEDGSLYRNNGSWHKHANLLFVDQPV
GTGLSVTDTNSYIHELPRMASDMMIFLDKYFEIFPERQNDDFYIAGESYAGQYIPYISRAILDRNLNKKSKYLELIDVKE
PSTKGDLAKEASKKFREKFGLDDKQKRDDDNDDEKKKDEEKTKEKETPAKKPFINLKAVLIGNGWIDPVSQYLTYLPFAY
NSGLIKHGSSVAAVVEKKHRDCAKYLDEHPEQQYDLSVRECESILNSLLRELYLETKLPRDSDKACVNMYDIRLTDTYAS
CGMNWPPDLSAVTPYLRRKDVLMSLNVPPTKGWKECSGPVGHAFKARHSHPSISIIPSLISDGLQVVMFNGDQDLICNHL
GNEKLIERIHWGSDALDEDDSESESAIDKVEAMRRHGGFHDDEKTEDWYMDGAAAGTIRSGRNMTYIKIYNASHMVPFDV
PLVSQGMLHQVMEIPGYEPKEQKIKALGEVAEQQQDQQKDEQKQNDGDKKDEEEGEKEGNVNAYYQAGAFILIIVIIVAL
FLAYFVWRNRTLTSQAMFNNSAHQRVRSVHYEDELDDYERNGNVSVDPTATTDRNNGFFASILSGITRWHKPASGSSSSN
SKNYGGYSKVGRNGSTAHLTSVGEEEEDDEYDDNQIPLSSMNSSNNNNNQRRTTGSGTNFNEDGSMRDSIDSILDELNAE
TERNTGQKTFD

GO term prediction

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0004185 serine-type carboxypeptidase activity

Cellular Component

None predicted.