Protein

MIA_00607_1

Length
930 amino acids

Browser: contig01:1746934-1749727-

Protein function

EGGNOG:0PFFDCHO2Catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis (By similarity)
SGD closest match:S000003389CHO2Phosphatidylethanolamine N-methyltransferase
CGD closest match:CAL0000189790CHO2Phosphatidylethanolamine N-methyltransferase

Protein alignments

%idAln lengthE-value
MCA_01095_171.492%8980.0MCA_01095_1
A0A0J9X4N9_GEOCN58.134%9220.0Phosphatidylethanolamine N-methyltransferase OS=Geotrichum candidum GN=BN980_GECA02s05367g PE=3 SV=1
UniRef50_A0A0J9X4N958.134%9220.0Phosphatidylethanolamine N-methyltransferase n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X4N9_GEOCN
A0A167FMJ8_9ASCO54.025%9440.0Phosphatidylethanolamine N-methyltransferase OS=Sugiyamaella lignohabitans GN=CHO2 PE=3 SV=1
A0A060THC6_BLAAD54.721%9320.0Phosphatidylethanolamine N-methyltransferase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D37730g PE=3 SV=1
CHO2_YARLI49.737%9490.0Phosphatidylethanolamine N-methyltransferase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=CHO2 PE=3 SV=1
A0A1E4TB26_9ASCO46.358%9060.0Phosphatidylethanolamine N-methyltransferase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_130659 PE=3 SV=1
A0A1E3PHW9_9ASCO40.066%9110.0Phosphatidylethanolamine N-methyltransferase (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_6849 PE=3 SV=1
CHO2_CANAL33.643%8627.61e-140Phosphatidylethanolamine N-methyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CHO2 PE=3 SV=1
CHO2_YEAST34.325%8072.57e-125Phosphatidylethanolamine N-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CHO2 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0426

Protein family membership

Domains and repeats

None predicted.

Detailed signature matches

  1. Family IPR007318
    Phospholipid methyltransferase
    1. PF04191 (PEMT)
  2. Family IPR016219
    Phosphatidylethanolamine N-methyltransferase, fungi
    1. MF_03217 (PEMT)
    2. PIRSF000383 (PEAMT)
    3. PS51598 (SAM_CHO2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. NON_CYTOPLASM... (N...)
  3. TMhelix
  4. TRANSMEMBRANE (Tran...)
  5. mobidb-lite (disord...)

Protein sequence

>MIA_00607_1
MSRPEPDSSQSPSVAASGADHHQTKAKPVLQSQPGQSNDATSTAIPDEPSKTAEPSSPSSGKIYGRTPDGTVFVVPETED
MVRTLFDPRIKKSLTDMIIVSVLTSYVLLYFVLPSYLRIPVYCVLFAFWRLAYNVGIGWLLSQQSNHKRLTKWSLQYHIF
DKTNANTFWQPLLKRDFTTKLGKDYDFYAAPNEYNTWLLFRHVVDLILMSDFTNYMMLAISCFSVTSQPFFMIFFRYIAG
LTLFFFNLWVKLDAHRVVKDFAWYWGDFFFLEDVQLTFDGVFEMAPHPMYSIGYAGFYGICLITASYTLFFASVLAHAAQ
FAFLILVENPHIEKTYNPPAPLKRKSTLDSDSHKKLRQSLQGQASPPHFGGINSSAVDDDDLATPERHAFLVFGNFHVTR
VSDILTVIAAFYAGLLTFLPHTVAWTSFAIYNAFFWRALLSFGFGYALRKQSQEKFLTKLFLKYGRTPDEAYQQWQIAYN
FATVMSYVSLTVVSIRHIHSPLDRPYWPFKYIIGAMLIALQTWTSYSIYESLGEFGWFFGDFFFPEKSKNLTYSGIYRYL
NNPERLFGIAGVWGLALISGSFIVTVLAFFWTLGVIFIIKFVEHPHMQKLYGGQIRDQSGVVKTIKRAAEAAKIIPPPVE
STVRKVQGSIDKVLHETASAVENFLEQKKLTTGVKDVVKETQVLLKEYPARLTIVRVTEDLHGLDASKYSLKIDTSVDED
QPLTFEYGTEITVKWTADPKHSNRDWIGLYKLTDNYSEEVTKISSQGRWSAIDATAYENHIDTVKSNNETSGEVVFKGDI
LPWTTGVYQFRYHHDGKHNCLAISRPFTVIATPIKGASAGGDGKALGTQLLPIVQRIFVASDFIPPLTVNENWDLEDPVV
TKRLVYAVKVYVGVDLAPEVLQSDQSVGQLATRLQRVTDALRPFTAVKTE

GO term prediction

Biological Process

GO:0006644 phospholipid metabolic process

Molecular Function

GO:0004608 phosphatidylethanolamine N-methyltransferase activity

Cellular Component

None predicted.