Protein

MCA_01095_1

Length
913 amino acids

Gene name: CHO2

Description: Phosphatidylethanolamine N-methyltransferase

Browser: contigA:3490132-3492937-

RNA-seq: read pairs 2249, FPKM 30.4, percentile rank 53.1% (100% = highest expression)

Protein function

Annotation:CHO2Phosphatidylethanolamine N-methyltransferase
KEGG:K16369CHO2 phosphatidylethanolamine N-methyltransferase [EC:2.1.1.17]
EGGNOG:0PFFDCHO2Catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis (By similarity)
SGD closest match:S000003389CHO2Phosphatidylethanolamine N-methyltransferase
CGD closest match:CAL0000189790CHO2Phosphatidylethanolamine N-methyltransferase

Protein alignments

%idAln lengthE-value
MIA_00607_171.49%8980.0MIA_00607_1
A0A0J9X4N9_GEOCN60.45%8800.0Phosphatidylethanolamine N-methyltransferase OS=Geotrichum candidum GN=BN980_GECA02s05367g PE=3 SV=1
UniRef50_A0A0J9X4N960.45%8800.0Phosphatidylethanolamine N-methyltransferase n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X4N9_GEOCN
A0A167FMJ8_9ASCO55.53%9490.0Phosphatidylethanolamine N-methyltransferase OS=Sugiyamaella lignohabitans GN=CHO2 PE=3 SV=1
A0A060THC6_BLAAD55.33%8910.0Phosphatidylethanolamine N-methyltransferase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D37730g PE=3 SV=1
CHO2_YARLI51.08%8830.0Phosphatidylethanolamine N-methyltransferase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=CHO2 PE=3 SV=1
A0A1E4TB26_9ASCO48.16%8990.0Phosphatidylethanolamine N-methyltransferase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_130659 PE=3 SV=1
A0A1E3PHW9_9ASCO40.88%9100.0Phosphatidylethanolamine N-methyltransferase (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_6849 PE=3 SV=1
CHO2_CANAL33.74%9074e-134Phosphatidylethanolamine N-methyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CHO2 PE=3 SV=1
CHO2_YEAST33.41%8929e-125Phosphatidylethanolamine N-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CHO2 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0123

Protein family membership

Domains and repeats

None predicted.

Detailed signature matches

  1. Family IPR007318
    Phospholipid methyltransferase
    1. PF04191 (PEMT)
  2. Family IPR016219
    Phosphatidylethanolamine N-methyltransferase, fungi
    1. MF_03217 (PEMT)
    2. PIRSF000383 (PEAMT)
    3. PS51598 (SAM_CHO2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. NON_CYTOPLASM... (N...)
  3. TMhelix
  4. TRANSMEMBRANE (Tran...)
  5. mobidb-lite (disord...)

Protein sequence

>MCA_01095_1
MSDFTPVSTTTGAQIHPSSANSKAPQEKQSPTARSEVPDDLKPQKVIGRTPDGTVFAVPHTEDMVRTLFDPRVKKSITDL
VIVLVLSFYVSLYFLLPSSWRIPIYCLLFAFWRLAYNAGIGWLLSQQSNHKRLTKWAQQYKLFSRENANTSWQKLLKHDL
SSKLGDDYDFYQVPLEYNTWLVFRHVVDLILMSDFTNYMMLAVSCFSWTSQPFYMICARWIAGLILFFFNLWVKLDAHRV
VKDYAWYWGDFFFLEDLQLTFDGVFEMAPHPMYSIGYAGFYGICLITSSYTLFWASILAHAAQFAFLIIVENPHIDKTYN
PPAPAKRKSTLDEKSSQKLKEAISGKASPPMLAVFNSSAVEDNELVIPERKALVLLENFHITRSSDLLTFLVAFYSLLLV
ALPRTTFWYAFTLFNAFFWRSFHSFGLGYVLSQQSKNKYLIRLFLKYGRTTSEAYEQWQVVYNFATILSYISLLIVGFRQ
WESPYTRTYWLFKYIIGGMLIALQSWTSYSIYESLGEFGWFFGDFFFPERAKTLTYSGIYRYLNNPERLFGIAGVWGLVL
LTGSFSVTVLAFIWTIGSIYMIKFVEQPHMQKLYGGQIRSQSGITKTIKNAAKIPPPVESTVRKVQGSIDKVINETASVL
EGFLDQAKPKLKTGVHDVVKDTQVLLKEYPARLTIVRVSDDMKGLDLTKYSLEITTPSISETQLEFEYGTEISVHWTADP
NHSPRDWIGLYKLTDNTSEDVTKVSSQGRWSAISTDAYDDHIDTVRSNNGTSGDVVFKGDTLFWKTGVYQFRYHHDGKHN
CLAISKPFTIVATPINGTDAKTLGNQLLPVVQKCFVASDFIPPLTINESWDLEDMTITKRLIYAIKEMIGVDLAPEVIMS
DKSVGQLATRLERIKEALRPYTATCQKEEPILT

GO term prediction

Biological Process

GO:0006644 phospholipid metabolic process

Molecular Function

GO:0004608 phosphatidylethanolamine N-methyltransferase activity

Cellular Component

None predicted.