Protein

MIA_00599_1

Length
404 amino acids

Browser: contig01:1721779-1722994+

Protein function

EGGNOG:0PG5VERG10Acetyl-CoA acetyltransferase
SGD closest match:S000005949ERG10Acetyl-CoA acetyltransferase
CGD closest match:CAL0000184591ERG10Acetyl-CoA C-acetyltransferase

Protein alignments

%idAln lengthE-value
MCA_05485_181.572%3690.0MCA_05485_1
S4SX04_GEOCN76.368%4020.0Acetyl-CoA acetyltransferase OS=Geotrichum candidum GN=Erg10 PE=2 SV=1
A0A161HK83_9ASCO74.659%3670.0Acetyl-CoA C-acetyltransferase OS=Sugiyamaella lignohabitans GN=ERG10 PE=3 SV=1
A0A1E3PKD4_9ASCO72.554%3680.0Acetyl-CoA c-acetyltransferase, cytosolic enzyme OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46480 PE=3 SV=1
Q6CFB6_YARLI70.652%3680.0YALI0B08536p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B08536g PE=3 SV=1
UniRef50_A0A060N5L267.024%3733.16e-177Acetyl-CoA acetyltransferase n=23 Tax=cellular organisms TaxID=131567 RepID=A0A060N5L2_CYBJA
A0A060TDE5_BLAAD66.938%3692.41e-177ARAD1D47278p OS=Blastobotrys adeninivorans GN=AKAT4 PE=3 SV=1
A0A1D8PH52_CANAL63.659%3999.61e-170Acetyl-CoA C-acetyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ERG10 PE=3 SV=1
THIL_YEAST61.892%3701.53e-159Acetyl-CoA acetyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERG10 PE=1 SV=3
A0A1E4TKV8_9ASCO61.186%3711.69e-154Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_970 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2614
Predicted cleavage: 17

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 404

Detailed signature matches

  1. Family IPR002155
    Thiolase
    1. TIGR01930
    2. cd00751 (thiolase)
    3. PIRSF000429 (Ac-CoA...)
  2. Domain IPR016039
    Thiolase-like
    1. SSF53901 (Thiolase-...)
    2. G3DSA:3.40.47.10
  3. Domain IPR020616
    Thiolase, N-terminal
    1. PF00108 (Thiolase_N)
  4. Domain IPR020617
    Thiolase, C-terminal
    1. PF02803 (Thiolase_C)
  5. SITE IPR020615
    Thiolase, acyl-enzyme intermediate active site
    1. PS00098 (THIOLASE_1)
  6. SITE IPR020613
    Thiolase, conserved site
    1. PS00737 (THIOLASE_2)
  7. SITE IPR020610
    Thiolase, active site
    1. PS00099 (THIOLASE_3)

Residue annotation

  1. dimer interface cd...
  2. active site cd00751

Protein sequence

>MIA_00599_1
MALNTNPVYIVAAARTPVGGLLGSLSSLTYPELGSHVVKAALAKVPQIKPTEVEEVVFGNVYGANLGQNPARQVALKAGL
GNDTIATTVNKVCASGLKAIIFGAQNILTGTADIVVAGGAESMSNVPHYLPDFRRGIKFGGSTVVDGMQRDGLQDAYDGQ
AMGVSADLCAIEHNISRQEQDDFAVESYKRSQKAHNDGKFKAEIAPIELPGFRGKPGVTVSTDEDAFKLNEDKLRSARAV
FTKDGTVTAPNASSINDGAAAVVLMSAQKVKELGVTPIAKIVGWGDAAQEPEKFTTSPSLAIPKALKHAGLSISDVDFFE
FNEAFSVVGLANSKILGLSSDKVNVYGGAVAIGHPLGCSGARIIATLLSVLTQEGGKIGAAAICNGGGGASALIVELVEP
SSKL

GO term prediction

Biological Process

GO:0008152 metabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups

Cellular Component

None predicted.