MIA_00562_1

Protein

Length

335 amino acids

Browser: contig01:1620247-1621255+

Protein function

EGGNOG:	0PI1D	PGUG_02769	ribokinase
SGD closest match:	S000000632	RBK1	Ribokinase
CGD closest match:	CAL0000181468	RBK1	Ribokinase

Protein alignments

	%id	Aln length	E-value
MCA_06364_1	62.426%	338	2.26e-147	MCA_06364_1
A0A0J9X8W9_GEOCN	56.637%	339	2.02e-122	Ribokinase OS=Geotrichum candidum GN=RBK1 PE=3 SV=1
UniRef50_A0A0J9X8W9	56.637%	339	4.13e-119	Ribokinase n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X8W9_GEOCN
Q6CEK6_YARLI	43.976%	332	2.18e-78	Ribokinase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=RBK1 PE=3 SV=1
A0A060TEX7_BLAAD	44.311%	334	1.17e-74	Ribokinase OS=Blastobotrys adeninivorans GN=RBK1 PE=3 SV=1
A0A1E3PJG2_9ASCO	41.003%	339	2.94e-65	Ribokinase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=RBK1 PE=3 SV=1
A0A167DCQ4_9ASCO	43.363%	339	6.33e-65	Ribokinase OS=Sugiyamaella lignohabitans GN=RBK1 PE=3 SV=1
A0A1E4TE04_9ASCO	38.806%	335	2.36e-58	Ribokinase OS=Tortispora caseinolytica NRRL Y-17796 GN=RBK1 PE=3 SV=1
RBSK_YEAST	38.218%	348	2.25e-57	Ribokinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RBK1 PE=1 SV=2
A0A1D8PFI3_CANAL	32.405%	395	1.90e-50	Ribokinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=RBK1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0738

Protein family membership

Ribokinase/fructokinase (IPR002139)
- Ribokinase (IPR011877)

Domains and repeats

Domain
1 - 334
Ribokinase-like (IPR029056)
Carbohydrate kinase PfkB (IPR011611)

1 50 100 150 200 250 300 335

Detailed signature matches

IPR002139

Ribokinase/fructokinase
1. PR00990 (RIBOKINASE)
  
  117 - 130
  
  PRINTS
  PR00990 (RIBOKINASE)
  
  247 - 258
  
  PRINTS
  PR00990 (RIBOKINASE)
  
  33 - 52
  
  PRINTS
  PR00990 (RIBOKINASE)
  
  6 - 27
  
  PRINTS
  PR00990 (RIBOKINASE)
IPR011877

Ribokinase
1. MF_01987 (Ribokinase)
  
  2 - 335
  
  HAMAP
  MF_01987 (Ribokinase)
2. cd01174 (ribokinase)
  
  4 - 328
  
  CDD
  cd01174 (ribokinase)
IPR029056

Ribokinase-like
1. G3DSA:3.40.11...
  
  1 - 334
  
  GENE3D
  G3DSA:3.40.1190.20 (G3DSA:3.40.1190.20)
2. SSF53613 (Ribokinas...)
  
  4 - 330
  
  SUPERFAMILY
  SSF53613 (Ribokinase-like)
IPR011611

Carbohydrate kinase PfkB
1. PF00294 (PfkB)
  
  1 - 328
  
  Pfam
  PF00294 (PfkB)
IPR002173

Carbohydrate/puine kinase, PfkB, conserved site
1. PS00584 (PFKB_KINAS...)
  
  281 - 294
  
  PROSITE patterns
  PS00584 (PFKB_KINASES_2)

Residue annotation

substrate binding ...

11N

substrate binding site
11N, 13D, 38G, 39G, 40K, 43N, 106A, 108I, 119I, 121V, 156E, 283T, 284G, 287D, 323A
CDD
cd01174 (ribokinase)

13D

substrate binding site
11N, 13D, 38G, 39G, 40K, 43N, 106A, 108I, 119I, 121V, 156E, 283T, 284G, 287D, 323A
CDD
cd01174 (ribokinase)

38G

substrate binding site
11N, 13D, 38G, 39G, 40K, 43N, 106A, 108I, 119I, 121V, 156E, 283T, 284G, 287D, 323A
CDD
cd01174 (ribokinase)

39G

substrate binding site
11N, 13D, 38G, 39G, 40K, 43N, 106A, 108I, 119I, 121V, 156E, 283T, 284G, 287D, 323A
CDD
cd01174 (ribokinase)

40K

substrate binding site
11N, 13D, 38G, 39G, 40K, 43N, 106A, 108I, 119I, 121V, 156E, 283T, 284G, 287D, 323A
CDD
cd01174 (ribokinase)

43N

substrate binding site
11N, 13D, 38G, 39G, 40K, 43N, 106A, 108I, 119I, 121V, 156E, 283T, 284G, 287D, 323A
CDD
cd01174 (ribokinase)

106A

substrate binding site
11N, 13D, 38G, 39G, 40K, 43N, 106A, 108I, 119I, 121V, 156E, 283T, 284G, 287D, 323A
CDD
cd01174 (ribokinase)

108I

substrate binding site
11N, 13D, 38G, 39G, 40K, 43N, 106A, 108I, 119I, 121V, 156E, 283T, 284G, 287D, 323A
CDD
cd01174 (ribokinase)

119I

substrate binding site
11N, 13D, 38G, 39G, 40K, 43N, 106A, 108I, 119I, 121V, 156E, 283T, 284G, 287D, 323A
CDD
cd01174 (ribokinase)

121V

substrate binding site
11N, 13D, 38G, 39G, 40K, 43N, 106A, 108I, 119I, 121V, 156E, 283T, 284G, 287D, 323A
CDD
cd01174 (ribokinase)

156E

substrate binding site
11N, 13D, 38G, 39G, 40K, 43N, 106A, 108I, 119I, 121V, 156E, 283T, 284G, 287D, 323A
CDD
cd01174 (ribokinase)

283T

substrate binding site
11N, 13D, 38G, 39G, 40K, 43N, 106A, 108I, 119I, 121V, 156E, 283T, 284G, 287D, 323A
CDD
cd01174 (ribokinase)

284G

substrate binding site
11N, 13D, 38G, 39G, 40K, 43N, 106A, 108I, 119I, 121V, 156E, 283T, 284G, 287D, 323A
CDD
cd01174 (ribokinase)

287D

substrate binding site
11N, 13D, 38G, 39G, 40K, 43N, 106A, 108I, 119I, 121V, 156E, 283T, 284G, 287D, 323A
CDD
cd01174 (ribokinase)

323A

substrate binding site
11N, 13D, 38G, 39G, 40K, 43N, 106A, 108I, 119I, 121V, 156E, 283T, 284G, 287D, 323A
CDD
cd01174 (ribokinase)
dimer interface cd...

14V

dimer interface
14V, 16T, 21L, 22P, 23N, 24A, 25G, 26E, 27T, 40K, 105V, 107T, 108I, 109L, 116Q, 117N, 118R, 119I, 120L, 121V, 122Y, 123P, 186P
CDD
cd01174 (ribokinase)

16T

dimer interface
14V, 16T, 21L, 22P, 23N, 24A, 25G, 26E, 27T, 40K, 105V, 107T, 108I, 109L, 116Q, 117N, 118R, 119I, 120L, 121V, 122Y, 123P, 186P
CDD
cd01174 (ribokinase)

21L

dimer interface
14V, 16T, 21L, 22P, 23N, 24A, 25G, 26E, 27T, 40K, 105V, 107T, 108I, 109L, 116Q, 117N, 118R, 119I, 120L, 121V, 122Y, 123P, 186P
CDD
cd01174 (ribokinase)

22P

dimer interface
14V, 16T, 21L, 22P, 23N, 24A, 25G, 26E, 27T, 40K, 105V, 107T, 108I, 109L, 116Q, 117N, 118R, 119I, 120L, 121V, 122Y, 123P, 186P
CDD
cd01174 (ribokinase)

23N

dimer interface
14V, 16T, 21L, 22P, 23N, 24A, 25G, 26E, 27T, 40K, 105V, 107T, 108I, 109L, 116Q, 117N, 118R, 119I, 120L, 121V, 122Y, 123P, 186P
CDD
cd01174 (ribokinase)

24A

dimer interface
14V, 16T, 21L, 22P, 23N, 24A, 25G, 26E, 27T, 40K, 105V, 107T, 108I, 109L, 116Q, 117N, 118R, 119I, 120L, 121V, 122Y, 123P, 186P
CDD
cd01174 (ribokinase)

25G

dimer interface
14V, 16T, 21L, 22P, 23N, 24A, 25G, 26E, 27T, 40K, 105V, 107T, 108I, 109L, 116Q, 117N, 118R, 119I, 120L, 121V, 122Y, 123P, 186P
CDD
cd01174 (ribokinase)

26E

dimer interface
14V, 16T, 21L, 22P, 23N, 24A, 25G, 26E, 27T, 40K, 105V, 107T, 108I, 109L, 116Q, 117N, 118R, 119I, 120L, 121V, 122Y, 123P, 186P
CDD
cd01174 (ribokinase)

27T

dimer interface
14V, 16T, 21L, 22P, 23N, 24A, 25G, 26E, 27T, 40K, 105V, 107T, 108I, 109L, 116Q, 117N, 118R, 119I, 120L, 121V, 122Y, 123P, 186P
CDD
cd01174 (ribokinase)

40K

dimer interface
14V, 16T, 21L, 22P, 23N, 24A, 25G, 26E, 27T, 40K, 105V, 107T, 108I, 109L, 116Q, 117N, 118R, 119I, 120L, 121V, 122Y, 123P, 186P
CDD
cd01174 (ribokinase)

105V

dimer interface
14V, 16T, 21L, 22P, 23N, 24A, 25G, 26E, 27T, 40K, 105V, 107T, 108I, 109L, 116Q, 117N, 118R, 119I, 120L, 121V, 122Y, 123P, 186P
CDD
cd01174 (ribokinase)

107T

dimer interface
14V, 16T, 21L, 22P, 23N, 24A, 25G, 26E, 27T, 40K, 105V, 107T, 108I, 109L, 116Q, 117N, 118R, 119I, 120L, 121V, 122Y, 123P, 186P
CDD
cd01174 (ribokinase)

108I

dimer interface
14V, 16T, 21L, 22P, 23N, 24A, 25G, 26E, 27T, 40K, 105V, 107T, 108I, 109L, 116Q, 117N, 118R, 119I, 120L, 121V, 122Y, 123P, 186P
CDD
cd01174 (ribokinase)

109L

dimer interface
14V, 16T, 21L, 22P, 23N, 24A, 25G, 26E, 27T, 40K, 105V, 107T, 108I, 109L, 116Q, 117N, 118R, 119I, 120L, 121V, 122Y, 123P, 186P
CDD
cd01174 (ribokinase)

116Q

dimer interface
14V, 16T, 21L, 22P, 23N, 24A, 25G, 26E, 27T, 40K, 105V, 107T, 108I, 109L, 116Q, 117N, 118R, 119I, 120L, 121V, 122Y, 123P, 186P
CDD
cd01174 (ribokinase)

117N

dimer interface
14V, 16T, 21L, 22P, 23N, 24A, 25G, 26E, 27T, 40K, 105V, 107T, 108I, 109L, 116Q, 117N, 118R, 119I, 120L, 121V, 122Y, 123P, 186P
CDD
cd01174 (ribokinase)

118R

dimer interface
14V, 16T, 21L, 22P, 23N, 24A, 25G, 26E, 27T, 40K, 105V, 107T, 108I, 109L, 116Q, 117N, 118R, 119I, 120L, 121V, 122Y, 123P, 186P
CDD
cd01174 (ribokinase)

119I

dimer interface
14V, 16T, 21L, 22P, 23N, 24A, 25G, 26E, 27T, 40K, 105V, 107T, 108I, 109L, 116Q, 117N, 118R, 119I, 120L, 121V, 122Y, 123P, 186P
CDD
cd01174 (ribokinase)

120L

dimer interface
14V, 16T, 21L, 22P, 23N, 24A, 25G, 26E, 27T, 40K, 105V, 107T, 108I, 109L, 116Q, 117N, 118R, 119I, 120L, 121V, 122Y, 123P, 186P
CDD
cd01174 (ribokinase)

121V

dimer interface
14V, 16T, 21L, 22P, 23N, 24A, 25G, 26E, 27T, 40K, 105V, 107T, 108I, 109L, 116Q, 117N, 118R, 119I, 120L, 121V, 122Y, 123P, 186P
CDD
cd01174 (ribokinase)

122Y

dimer interface
14V, 16T, 21L, 22P, 23N, 24A, 25G, 26E, 27T, 40K, 105V, 107T, 108I, 109L, 116Q, 117N, 118R, 119I, 120L, 121V, 122Y, 123P, 186P
CDD
cd01174 (ribokinase)

123P

dimer interface
14V, 16T, 21L, 22P, 23N, 24A, 25G, 26E, 27T, 40K, 105V, 107T, 108I, 109L, 116Q, 117N, 118R, 119I, 120L, 121V, 122Y, 123P, 186P
CDD
cd01174 (ribokinase)

186P

dimer interface
14V, 16T, 21L, 22P, 23N, 24A, 25G, 26E, 27T, 40K, 105V, 107T, 108I, 109L, 116Q, 117N, 118R, 119I, 120L, 121V, 122Y, 123P, 186P
CDD
cd01174 (ribokinase)
ATP binding site c...

205N

ATP binding site
205N, 250T, 251L, 252G, 255G, 271P, 279I, 282T, 285A, 286G, 289F, 311L, 314S, 315S, 318I
CDD
cd01174 (ribokinase)

250T

ATP binding site
205N, 250T, 251L, 252G, 255G, 271P, 279I, 282T, 285A, 286G, 289F, 311L, 314S, 315S, 318I
CDD
cd01174 (ribokinase)

251L

ATP binding site
205N, 250T, 251L, 252G, 255G, 271P, 279I, 282T, 285A, 286G, 289F, 311L, 314S, 315S, 318I
CDD
cd01174 (ribokinase)

252G

ATP binding site
205N, 250T, 251L, 252G, 255G, 271P, 279I, 282T, 285A, 286G, 289F, 311L, 314S, 315S, 318I
CDD
cd01174 (ribokinase)

255G

ATP binding site
205N, 250T, 251L, 252G, 255G, 271P, 279I, 282T, 285A, 286G, 289F, 311L, 314S, 315S, 318I
CDD
cd01174 (ribokinase)

271P

ATP binding site
205N, 250T, 251L, 252G, 255G, 271P, 279I, 282T, 285A, 286G, 289F, 311L, 314S, 315S, 318I
CDD
cd01174 (ribokinase)

279I

ATP binding site
205N, 250T, 251L, 252G, 255G, 271P, 279I, 282T, 285A, 286G, 289F, 311L, 314S, 315S, 318I
CDD
cd01174 (ribokinase)

282T

ATP binding site
205N, 250T, 251L, 252G, 255G, 271P, 279I, 282T, 285A, 286G, 289F, 311L, 314S, 315S, 318I
CDD
cd01174 (ribokinase)

285A

ATP binding site
205N, 250T, 251L, 252G, 255G, 271P, 279I, 282T, 285A, 286G, 289F, 311L, 314S, 315S, 318I
CDD
cd01174 (ribokinase)

286G

ATP binding site
205N, 250T, 251L, 252G, 255G, 271P, 279I, 282T, 285A, 286G, 289F, 311L, 314S, 315S, 318I
CDD
cd01174 (ribokinase)

289F

ATP binding site
205N, 250T, 251L, 252G, 255G, 271P, 279I, 282T, 285A, 286G, 289F, 311L, 314S, 315S, 318I
CDD
cd01174 (ribokinase)

311L

ATP binding site
205N, 250T, 251L, 252G, 255G, 271P, 279I, 282T, 285A, 286G, 289F, 311L, 314S, 315S, 318I
CDD
cd01174 (ribokinase)

314S

ATP binding site
205N, 250T, 251L, 252G, 255G, 271P, 279I, 282T, 285A, 286G, 289F, 311L, 314S, 315S, 318I
CDD
cd01174 (ribokinase)

315S

ATP binding site
205N, 250T, 251L, 252G, 255G, 271P, 279I, 282T, 285A, 286G, 289F, 311L, 314S, 315S, 318I
CDD
cd01174 (ribokinase)

318I

ATP binding site
205N, 250T, 251L, 252G, 255G, 271P, 279I, 282T, 285A, 286G, 289F, 311L, 314S, 315S, 318I
CDD
cd01174 (ribokinase)

Protein sequence

>MIA_00562_1
MPTITVVGSLNYDVVTTYSRLPNAGETIPAKNFETHNGGKGANQALACARLRTKAGPSPSVNVKMVGCVGDDNFGSTLKK
SLSKSDVDISGVRTLDKSTNIGTGVATILVDGESGQNRILVYPGANSQVSKEDVLKAIIDSEKNIFVTDSLILQNEIPVS
LVQEIIKTTIDSRYGDKPFIIYNPSPIDASFDNSLYKYIDCLIVNSTEAKAIVPENVGSLLVDDDNAEQALQAAVPIFQA
LNLPKYLIITLGAAGCVYVDGTVLLEARHIPAVKPPKPIIDTTGAGDTFLGAIASQLTEGNELKQALHVALTASSIAITR
MGAGDGIPEFRELVL

GO term prediction

Biological Process

GO:0006014 D-ribose metabolic process

Molecular Function

GO:0004747 ribokinase activity
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor

Cellular Component

None predicted.

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Entry type

Status

Per-residue features