MCA_06364_1

Protein

Length

337 amino acids

RNA-seq: read pairs 598, FPKM 21.9, percentile rank 43.8% (100% = highest expression)

Protein function

KEGG:	K00852	rbsK	ribokinase [EC:2.7.1.15]
EGGNOG:	0PI1D	PGUG_02769	ribokinase
SGD closest match:	S000000632	RBK1	Ribokinase
CGD closest match:	CAL0000181468	RBK1	Ribokinase

Protein alignments

	%id	Aln length	E-value
MIA_00562_1	62.43%	338	1e-145	MIA_00562_1
A0A0J9X8W9_GEOCN	52.65%	340	2e-117	Ribokinase OS=Geotrichum candidum GN=RBK1 PE=3 SV=1
UniRef50_A0A0J9X8W9	52.65%	340	4e-114	Ribokinase n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X8W9_GEOCN
Q6CEK6_YARLI	44.05%	336	3e-83	Ribokinase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=RBK1 PE=3 SV=1
A0A060TEX7_BLAAD	43.03%	337	3e-76	Ribokinase OS=Blastobotrys adeninivorans GN=RBK1 PE=3 SV=1
A0A167DCQ4_9ASCO	43.15%	343	3e-70	Ribokinase OS=Sugiyamaella lignohabitans GN=RBK1 PE=3 SV=1
A0A1E3PJG2_9ASCO	41.23%	342	4e-70	Ribokinase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=RBK1 PE=3 SV=1
RBSK_YEAST	39.37%	348	3e-62	Ribokinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RBK1 PE=1 SV=2
A0A1E4TE04_9ASCO	39.59%	341	8e-60	Ribokinase OS=Tortispora caseinolytica NRRL Y-17796 GN=RBK1 PE=3 SV=1
A0A1D8PFI3_CANAL	32.42%	401	2e-49	Ribokinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=RBK1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0281

Protein family membership

Ribokinase/fructokinase (IPR002139)
- Ribokinase (IPR011877)

Domains and repeats

Domain
1 - 337
Ribokinase-like (IPR029056)
Carbohydrate kinase PfkB (IPR011611)

1 50 100 150 200 250 300 337

Detailed signature matches

IPR002139

Ribokinase/fructokinase
1. PR00990 (RIBOKINASE)
  
  33 - 52
  
  PRINTS
  PR00990 (RIBOKINASE)
  
  6 - 27
  
  PRINTS
  PR00990 (RIBOKINASE)
  
  251 - 262
  
  PRINTS
  PR00990 (RIBOKINASE)
  
  116 - 129
  
  PRINTS
  PR00990 (RIBOKINASE)
IPR011877

Ribokinase
1. MF_01987 (Ribokinase)
  
  2 - 337
  
  HAMAP
  MF_01987 (Ribokinase)
2. cd01174 (ribokinase)
  
  4 - 332
  
  CDD
  cd01174 (ribokinase)
IPR029056

Ribokinase-like
1. G3DSA:3.40.11...
  
  1 - 337
  
  GENE3D
  G3DSA:3.40.1190.20 (G3DSA:3.40.1190.20)
2. SSF53613 (Ribokinas...)
  
  4 - 336
  
  SUPERFAMILY
  SSF53613 (Ribokinase-like)
IPR011611

Carbohydrate kinase PfkB
1. PF00294 (PfkB)
  
  1 - 332
  
  Pfam
  PF00294 (PfkB)
IPR002173

Carbohydrate/puine kinase, PfkB, conserved site
1. PS00584 (PFKB_KINAS...)
  
  285 - 298
  
  PROSITE patterns
  PS00584 (PFKB_KINASES_2)

Residue annotation

substrate binding ...

11N

substrate binding site
11N, 13D, 38G, 39G, 40K, 43N, 105A, 107I, 118I, 120V, 157E, 287T, 288G, 291D, 327A
CDD
cd01174 (ribokinase)

13D

substrate binding site
11N, 13D, 38G, 39G, 40K, 43N, 105A, 107I, 118I, 120V, 157E, 287T, 288G, 291D, 327A
CDD
cd01174 (ribokinase)

38G

substrate binding site
11N, 13D, 38G, 39G, 40K, 43N, 105A, 107I, 118I, 120V, 157E, 287T, 288G, 291D, 327A
CDD
cd01174 (ribokinase)

39G

substrate binding site
11N, 13D, 38G, 39G, 40K, 43N, 105A, 107I, 118I, 120V, 157E, 287T, 288G, 291D, 327A
CDD
cd01174 (ribokinase)

40K

substrate binding site
11N, 13D, 38G, 39G, 40K, 43N, 105A, 107I, 118I, 120V, 157E, 287T, 288G, 291D, 327A
CDD
cd01174 (ribokinase)

43N

substrate binding site
11N, 13D, 38G, 39G, 40K, 43N, 105A, 107I, 118I, 120V, 157E, 287T, 288G, 291D, 327A
CDD
cd01174 (ribokinase)

105A

substrate binding site
11N, 13D, 38G, 39G, 40K, 43N, 105A, 107I, 118I, 120V, 157E, 287T, 288G, 291D, 327A
CDD
cd01174 (ribokinase)

107I

substrate binding site
11N, 13D, 38G, 39G, 40K, 43N, 105A, 107I, 118I, 120V, 157E, 287T, 288G, 291D, 327A
CDD
cd01174 (ribokinase)

118I

substrate binding site
11N, 13D, 38G, 39G, 40K, 43N, 105A, 107I, 118I, 120V, 157E, 287T, 288G, 291D, 327A
CDD
cd01174 (ribokinase)

120V

substrate binding site
11N, 13D, 38G, 39G, 40K, 43N, 105A, 107I, 118I, 120V, 157E, 287T, 288G, 291D, 327A
CDD
cd01174 (ribokinase)

157E

substrate binding site
11N, 13D, 38G, 39G, 40K, 43N, 105A, 107I, 118I, 120V, 157E, 287T, 288G, 291D, 327A
CDD
cd01174 (ribokinase)

287T

substrate binding site
11N, 13D, 38G, 39G, 40K, 43N, 105A, 107I, 118I, 120V, 157E, 287T, 288G, 291D, 327A
CDD
cd01174 (ribokinase)

288G

substrate binding site
11N, 13D, 38G, 39G, 40K, 43N, 105A, 107I, 118I, 120V, 157E, 287T, 288G, 291D, 327A
CDD
cd01174 (ribokinase)

291D

substrate binding site
11N, 13D, 38G, 39G, 40K, 43N, 105A, 107I, 118I, 120V, 157E, 287T, 288G, 291D, 327A
CDD
cd01174 (ribokinase)

327A

substrate binding site
11N, 13D, 38G, 39G, 40K, 43N, 105A, 107I, 118I, 120V, 157E, 287T, 288G, 291D, 327A
CDD
cd01174 (ribokinase)
dimer interface cd...

14L

dimer interface
14L, 16T, 21F, 22P, 23E, 24A, 25G, 26E, 27T, 40K, 104V, 106T, 107I, 108L, 115Q, 116N, 117R, 118I, 119L, 120V, 121Y, 122P, 190P
CDD
cd01174 (ribokinase)

16T

dimer interface
14L, 16T, 21F, 22P, 23E, 24A, 25G, 26E, 27T, 40K, 104V, 106T, 107I, 108L, 115Q, 116N, 117R, 118I, 119L, 120V, 121Y, 122P, 190P
CDD
cd01174 (ribokinase)

21F

dimer interface
14L, 16T, 21F, 22P, 23E, 24A, 25G, 26E, 27T, 40K, 104V, 106T, 107I, 108L, 115Q, 116N, 117R, 118I, 119L, 120V, 121Y, 122P, 190P
CDD
cd01174 (ribokinase)

22P

dimer interface
14L, 16T, 21F, 22P, 23E, 24A, 25G, 26E, 27T, 40K, 104V, 106T, 107I, 108L, 115Q, 116N, 117R, 118I, 119L, 120V, 121Y, 122P, 190P
CDD
cd01174 (ribokinase)

23E

dimer interface
14L, 16T, 21F, 22P, 23E, 24A, 25G, 26E, 27T, 40K, 104V, 106T, 107I, 108L, 115Q, 116N, 117R, 118I, 119L, 120V, 121Y, 122P, 190P
CDD
cd01174 (ribokinase)

24A

dimer interface
14L, 16T, 21F, 22P, 23E, 24A, 25G, 26E, 27T, 40K, 104V, 106T, 107I, 108L, 115Q, 116N, 117R, 118I, 119L, 120V, 121Y, 122P, 190P
CDD
cd01174 (ribokinase)

25G

dimer interface
14L, 16T, 21F, 22P, 23E, 24A, 25G, 26E, 27T, 40K, 104V, 106T, 107I, 108L, 115Q, 116N, 117R, 118I, 119L, 120V, 121Y, 122P, 190P
CDD
cd01174 (ribokinase)

26E

dimer interface
14L, 16T, 21F, 22P, 23E, 24A, 25G, 26E, 27T, 40K, 104V, 106T, 107I, 108L, 115Q, 116N, 117R, 118I, 119L, 120V, 121Y, 122P, 190P
CDD
cd01174 (ribokinase)

27T

dimer interface
14L, 16T, 21F, 22P, 23E, 24A, 25G, 26E, 27T, 40K, 104V, 106T, 107I, 108L, 115Q, 116N, 117R, 118I, 119L, 120V, 121Y, 122P, 190P
CDD
cd01174 (ribokinase)

40K

dimer interface
14L, 16T, 21F, 22P, 23E, 24A, 25G, 26E, 27T, 40K, 104V, 106T, 107I, 108L, 115Q, 116N, 117R, 118I, 119L, 120V, 121Y, 122P, 190P
CDD
cd01174 (ribokinase)

104V

dimer interface
14L, 16T, 21F, 22P, 23E, 24A, 25G, 26E, 27T, 40K, 104V, 106T, 107I, 108L, 115Q, 116N, 117R, 118I, 119L, 120V, 121Y, 122P, 190P
CDD
cd01174 (ribokinase)

106T

dimer interface
14L, 16T, 21F, 22P, 23E, 24A, 25G, 26E, 27T, 40K, 104V, 106T, 107I, 108L, 115Q, 116N, 117R, 118I, 119L, 120V, 121Y, 122P, 190P
CDD
cd01174 (ribokinase)

107I

dimer interface
14L, 16T, 21F, 22P, 23E, 24A, 25G, 26E, 27T, 40K, 104V, 106T, 107I, 108L, 115Q, 116N, 117R, 118I, 119L, 120V, 121Y, 122P, 190P
CDD
cd01174 (ribokinase)

108L

dimer interface
14L, 16T, 21F, 22P, 23E, 24A, 25G, 26E, 27T, 40K, 104V, 106T, 107I, 108L, 115Q, 116N, 117R, 118I, 119L, 120V, 121Y, 122P, 190P
CDD
cd01174 (ribokinase)

115Q

dimer interface
14L, 16T, 21F, 22P, 23E, 24A, 25G, 26E, 27T, 40K, 104V, 106T, 107I, 108L, 115Q, 116N, 117R, 118I, 119L, 120V, 121Y, 122P, 190P
CDD
cd01174 (ribokinase)

116N

dimer interface
14L, 16T, 21F, 22P, 23E, 24A, 25G, 26E, 27T, 40K, 104V, 106T, 107I, 108L, 115Q, 116N, 117R, 118I, 119L, 120V, 121Y, 122P, 190P
CDD
cd01174 (ribokinase)

117R

dimer interface
14L, 16T, 21F, 22P, 23E, 24A, 25G, 26E, 27T, 40K, 104V, 106T, 107I, 108L, 115Q, 116N, 117R, 118I, 119L, 120V, 121Y, 122P, 190P
CDD
cd01174 (ribokinase)

118I

dimer interface
14L, 16T, 21F, 22P, 23E, 24A, 25G, 26E, 27T, 40K, 104V, 106T, 107I, 108L, 115Q, 116N, 117R, 118I, 119L, 120V, 121Y, 122P, 190P
CDD
cd01174 (ribokinase)

119L

dimer interface
14L, 16T, 21F, 22P, 23E, 24A, 25G, 26E, 27T, 40K, 104V, 106T, 107I, 108L, 115Q, 116N, 117R, 118I, 119L, 120V, 121Y, 122P, 190P
CDD
cd01174 (ribokinase)

120V

dimer interface
14L, 16T, 21F, 22P, 23E, 24A, 25G, 26E, 27T, 40K, 104V, 106T, 107I, 108L, 115Q, 116N, 117R, 118I, 119L, 120V, 121Y, 122P, 190P
CDD
cd01174 (ribokinase)

121Y

dimer interface
14L, 16T, 21F, 22P, 23E, 24A, 25G, 26E, 27T, 40K, 104V, 106T, 107I, 108L, 115Q, 116N, 117R, 118I, 119L, 120V, 121Y, 122P, 190P
CDD
cd01174 (ribokinase)

122P

dimer interface
14L, 16T, 21F, 22P, 23E, 24A, 25G, 26E, 27T, 40K, 104V, 106T, 107I, 108L, 115Q, 116N, 117R, 118I, 119L, 120V, 121Y, 122P, 190P
CDD
cd01174 (ribokinase)

190P

dimer interface
14L, 16T, 21F, 22P, 23E, 24A, 25G, 26E, 27T, 40K, 104V, 106T, 107I, 108L, 115Q, 116N, 117R, 118I, 119L, 120V, 121Y, 122P, 190P
CDD
cd01174 (ribokinase)
ATP binding site c...

209N

ATP binding site
209N, 254T, 255L, 256G, 259G, 275P, 283V, 286T, 289A, 290G, 293F, 315L, 318S, 319S, 322V
CDD
cd01174 (ribokinase)

254T

ATP binding site
209N, 254T, 255L, 256G, 259G, 275P, 283V, 286T, 289A, 290G, 293F, 315L, 318S, 319S, 322V
CDD
cd01174 (ribokinase)

255L

ATP binding site
209N, 254T, 255L, 256G, 259G, 275P, 283V, 286T, 289A, 290G, 293F, 315L, 318S, 319S, 322V
CDD
cd01174 (ribokinase)

256G

ATP binding site
209N, 254T, 255L, 256G, 259G, 275P, 283V, 286T, 289A, 290G, 293F, 315L, 318S, 319S, 322V
CDD
cd01174 (ribokinase)

259G

ATP binding site
209N, 254T, 255L, 256G, 259G, 275P, 283V, 286T, 289A, 290G, 293F, 315L, 318S, 319S, 322V
CDD
cd01174 (ribokinase)

275P

ATP binding site
209N, 254T, 255L, 256G, 259G, 275P, 283V, 286T, 289A, 290G, 293F, 315L, 318S, 319S, 322V
CDD
cd01174 (ribokinase)

283V

ATP binding site
209N, 254T, 255L, 256G, 259G, 275P, 283V, 286T, 289A, 290G, 293F, 315L, 318S, 319S, 322V
CDD
cd01174 (ribokinase)

286T

ATP binding site
209N, 254T, 255L, 256G, 259G, 275P, 283V, 286T, 289A, 290G, 293F, 315L, 318S, 319S, 322V
CDD
cd01174 (ribokinase)

289A

ATP binding site
209N, 254T, 255L, 256G, 259G, 275P, 283V, 286T, 289A, 290G, 293F, 315L, 318S, 319S, 322V
CDD
cd01174 (ribokinase)

290G

ATP binding site
209N, 254T, 255L, 256G, 259G, 275P, 283V, 286T, 289A, 290G, 293F, 315L, 318S, 319S, 322V
CDD
cd01174 (ribokinase)

293F

ATP binding site
209N, 254T, 255L, 256G, 259G, 275P, 283V, 286T, 289A, 290G, 293F, 315L, 318S, 319S, 322V
CDD
cd01174 (ribokinase)

315L

ATP binding site
209N, 254T, 255L, 256G, 259G, 275P, 283V, 286T, 289A, 290G, 293F, 315L, 318S, 319S, 322V
CDD
cd01174 (ribokinase)

318S

ATP binding site
209N, 254T, 255L, 256G, 259G, 275P, 283V, 286T, 289A, 290G, 293F, 315L, 318S, 319S, 322V
CDD
cd01174 (ribokinase)

319S

ATP binding site
209N, 254T, 255L, 256G, 259G, 275P, 283V, 286T, 289A, 290G, 293F, 315L, 318S, 319S, 322V
CDD
cd01174 (ribokinase)

322V

ATP binding site
209N, 254T, 255L, 256G, 259G, 275P, 283V, 286T, 289A, 290G, 293F, 315L, 318S, 319S, 322V
CDD
cd01174 (ribokinase)

Protein sequence

>MCA_06364_1
MPTITVVGSLNYDLVTINDRFPEAGETISAQQFETHCGGKGSNQALACCRLRSTDSIGNIKIKMIGCVGPDSFGEELKSA
LEEAGADISAIMTIPAEKGIQTGVATILVDSTNGQNRILVYPGANACLTEEQVLDQLIDKNNDTTPFKTDAVVLQNEIPV
SIVRKVIQTLQDVAVSSKTTKPFIMYNPSPIDASFGTDLYQYVDCLIVNSTEAKAIVPEEVSKILTDDDNAEQALQAAEP
IAKTLNLPKYLVITLGAAGCVYYINKENGKPIHLPACKPPKPVIDTTGAGDTFLGGLTAQLTEGKTIEEALAVALKASSI
AVTRKGAGSGIPLFKEL

GO term prediction

Biological Process

GO:0006014 D-ribose metabolic process

Molecular Function

GO:0004747 ribokinase activity
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features