Protein

MIA_00558_1

Length
487 amino acids

Browser: contig01:1608089-1609553+

Protein function

EGGNOG:0PFTCNFS1cysteine desulfurase
SGD closest match:S000000522NFS1Cysteine desulfurase, mitochondrial
CGD closest match:CAL0000182012NFS1Cysteine desulfurase, mitochondrial

Protein alignments

%idAln lengthE-value
MCA_01889_184.634%4230.0MCA_01889_1
A0A0J9X3X1_GEOCN82.898%4210.0Similar to Saccharomyces cerevisiae YCL017C NFS1 Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs OS=Geotrichum candidum GN=BN980_GECA02s01286g PE=3 SV=1
UniRef50_P0DN3180.241%4150.0Cysteine desulfurase, mitochondrial n=17 Tax=Opisthokonta TaxID=33154 RepID=NFS1_ARTBC
A0A060TGZ3_BLAAD80.723%4150.0ARAD1D34738p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D34738g PE=3 SV=1
A0A161HK31_9ASCO78.774%4240.0Nfs1p OS=Sugiyamaella lignohabitans GN=NFS1 PE=3 SV=1
Q6CBG6_YARLI79.952%4140.0YALI0C19041p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C19041g PE=3 SV=1
A0A1E3PNY8_9ASCO82.000%4000.0Cysteine desulfurase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81719 PE=3 SV=1
NFS1_YEAST78.750%4000.0Cysteine desulfurase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NFS1 PE=1 SV=2
A0A1E4TF79_9ASCO74.825%4290.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31366 PE=3 SV=1
NFS1_CANAL74.359%4290.0Cysteine desulfurase, mitochondrial OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=NFS1 PE=2 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9993
Predicted cleavage: 41

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 450 487

Detailed signature matches

  1. Family IPR010240
    Cysteine desulfurase IscS
    1. MF_00331 (Cys_desul...)
    2. TIGR02006
  2. Domain IPR015421
    Pyridoxal phosphate-dependent transferase, major region, subdomain 1
    1. G3DSA:3.40.64...
  3. Domain IPR015424
    Pyridoxal phosphate-dependent transferase
    1. SSF53383 (PLP-depen...)
  4. Domain IPR000192
    Aminotransferase class V domain
    1. PF00266 (Aminotran_5)
  5. Domain IPR015422
    Pyridoxal phosphate-dependent transferase, subdomain 2
    1. G3DSA:3.90.11...
  6. SITE IPR020578
    Aminotransferase class-V, pyridoxal-phosphate binding site
    1. PS00595 (AA_TRANSFE...)

Protein sequence

>MIA_00558_1
MFRLTCRNIANRASLSSARLSARSANPTLTRFISNSNAPLSATATTATTEADLLNAAGSAVSKQPPADSHMFNSVKEAEI
VRSKDAERPIYLDMQATTPTDPRVLDVMLKFYTGLYGNPHSSTHAYGWETDTAIEEARAHIANLIGADPKEIIFTSGATE
SNNLSIKGVARFYKNKKKHIITTQTEHKCVLNACRSLQDDGFEVTYLPVQNNGLVDLKLLEAEIRPETALVSIMSVNNEI
GVIQPIEEIGRLCRSRKVFFHTDAAQATGKIPIDVNKLNVDLMSISGHKIYGPKGIGALYVRRRPRVRLDPLISGGGQER
GLRSGTLAPPLVAGFGEACRIAKEEMAYDSAHIKRLSDRLKKELLSLDHTILNGDPDAHYPGCINISFAYIEGESLLMAL
KDIALSSGSACTSASLEPSYVLHALGADDALAHSSIRFGIGRFTTDAEIDYVIKAVKERVNFLRELSPLWEMVQEGIDLN
SIEWSGH

GO term prediction

Biological Process

GO:0044571 [2Fe-2S] cluster assembly

Molecular Function

GO:0003824 catalytic activity
GO:0030170 pyridoxal phosphate binding
GO:0031071 cysteine desulfurase activity

Cellular Component

None predicted.