Protein

MCA_01889_1

Length
497 amino acids

Gene name: NFS1

Description: Cysteine desulfurase, mitochondrial

Browser: contigA:5785493-5786987-

RNA-seq: read pairs 7085, FPKM 175.8, percentile rank 86.6% (100% = highest expression)

Protein function

Annotation:NFS1Cysteine desulfurase, mitochondrial
KEGG:K04487iscS cysteine desulfurase [EC:2.8.1.7]
EGGNOG:0PFTCNFS1cysteine desulfurase
SGD closest match:S000000522NFS1Cysteine desulfurase, mitochondrial
CGD closest match:CAL0000182012NFS1Cysteine desulfurase, mitochondrial

Protein alignments

%idAln lengthE-value
MIA_00558_175.50%5020.0MIA_00558_1
A0A0J9X3X1_GEOCN85.99%4210.0Similar to Saccharomyces cerevisiae YCL017C NFS1 Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs OS=Geotrichum candidum GN=BN980_GECA02s01286g PE=3 SV=1
A0A060TGZ3_BLAAD82.65%4150.0ARAD1D34738p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D34738g PE=3 SV=1
Q6CBG6_YARLI81.06%4170.0YALI0C19041p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C19041g PE=3 SV=1
A0A161HK31_9ASCO78.86%4210.0Nfs1p OS=Sugiyamaella lignohabitans GN=NFS1 PE=3 SV=1
A0A1E3PNY8_9ASCO81.00%4000.0Cysteine desulfurase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81719 PE=3 SV=1
UniRef50_P0DN3178.91%4030.0Cysteine desulfurase, mitochondrial n=17 Tax=Opisthokonta TaxID=33154 RepID=NFS1_ARTBC
A0A1E4TF79_9ASCO77.72%4130.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31366 PE=3 SV=1
NFS1_YEAST78.38%4070.0Cysteine desulfurase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NFS1 PE=1 SV=2
NFS1_CANAL74.05%4200.0Cysteine desulfurase, mitochondrial OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=NFS1 PE=2 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9990
Predicted cleavage: 45

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 450 497

Detailed signature matches

  1. Family IPR010240
    Cysteine desulfurase IscS
    1. MF_00331 (Cys_desul...)
    2. TIGR02006
  2. Domain IPR015421
    Pyridoxal phosphate-dependent transferase, major region, subdomain 1
    1. G3DSA:3.40.64...
  3. Domain IPR015424
    Pyridoxal phosphate-dependent transferase
    1. SSF53383 (PLP-depen...)
  4. Domain IPR000192
    Aminotransferase class V domain
    1. PF00266 (Aminotran_5)
  5. Domain IPR015422
    Pyridoxal phosphate-dependent transferase, subdomain 2
    1. G3DSA:3.90.11...
  6. SITE IPR020578
    Aminotransferase class-V, pyridoxal-phosphate binding site
    1. PS00595 (AA_TRANSFE...)

Protein sequence

>MCA_01889_1
MFRSTARNLIASSKRSVITTNPTFKSVTRNQFAFRCLSGSQSPLKASIIDEKTIVDTKHQPTATSSNIASSASIPNDSHM
VSSIQDAQVVETKGASDRPIYLDMQATTPTDPRVLDVMLKFYTEYYGNPHSRTHAYGWETDTAVEEARAHVASLIGADPK
EIIFTSGATESNNTAIKGVSRFYKSRKKHIITTQTEHKCVLNACRSLQDEGFEVTYLPVQSNGLIDLEQLKAEIRPDTAM
VSVMFVNNEIGVIQPIEEIGKICRARKVYFHTDAAQATGKVPIDVNKMNIDLLSISGHKIYGPMGIGALYVRRRPRVRLE
PLISGGGQERGLRSGTLAAPLVAGFGEACRIAKEEMAYDSEHIKRLSDKLKDGILKLEHTVLNGDPERHYPGCVNISFAY
VEGESLLMALKDIALSSGSACTSSSLEPSYVLRALGADDALAHSSIRFGIGRFTTEAEIDYVLKAVQDRVNFLRELSPLW
EMVQEGIDLDSIEWSQH

GO term prediction

Biological Process

GO:0044571 [2Fe-2S] cluster assembly

Molecular Function

GO:0003824 catalytic activity
GO:0030170 pyridoxal phosphate binding
GO:0031071 cysteine desulfurase activity

Cellular Component

None predicted.