Protein

MIA_00552_1

Length
421 amino acids

Browser: contig01:1594580-1595846+

Protein function

EGGNOG:0PFG5FG10374.1dihydroceramide delta(4)-desaturase
CGD closest match:CAL0000198792DES1Sphingolipid delta(4)-desaturase

Protein alignments

%idAln lengthE-value
MCA_01845_168.564%4040.0MCA_01845_1
A0A0J9XIK7_GEOCN68.079%3545.77e-175Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA21s00571g PE=4 SV=1
A0A1E3PJT9_9ASCO61.394%3734.02e-157Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46359 PE=4 SV=1
Q6CA36_YARLI60.795%3521.08e-148YALI0D06237p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D06237g PE=4 SV=1
A0A1E4TE26_9ASCO60.000%3451.64e-148Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1731 PE=4 SV=1
A0A060SYC7_BLAAD60.845%3555.87e-148ARAD1A11418p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A11418g PE=4 SV=1
A0A167E5R9_9ASCO57.550%3513.06e-142Sphingolipid delta-4 desaturase OS=Sugiyamaella lignohabitans GN=DES1 PE=4 SV=1
UniRef50_A0A1V2L9K255.652%3451.33e-130Dihydroceramide delta(4)-desaturase (Fragment) n=1 Tax=Pichia kudriavzevii TaxID=4909 RepID=A0A1V2L9K2_PICKU
DEGS_CANAL52.055%3659.36e-127Sphingolipid delta(4)-desaturase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=DES1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1917

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 421

Detailed signature matches

  1. Family IPR011388
    Sphingolipid delta4-desaturase
    1. cd03508 (Delta4-sph...)
    2. PIRSF017228 (Sphngl...)
  2. Domain IPR013866
    Sphingolipid delta4-desaturase, N-terminal
    1. PF08557 (Lipid_DES)
    2. SM01269 (Lipid_DES_2)
  3. Domain IPR005804
    Fatty acid desaturase domain
    1. PF00487 (FA_desaturase)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. NON_CYTOPLASM... (N...)
  3. TMhelix
  4. TRANSMEMBRANE (Tran...)
  5. mobidb-lite (disord...)

Residue annotation

  1. putative di-iron l...

Protein sequence

>MIA_00552_1
MSSTSIEPINSPADSTLPPDSLPEVASSIVDDETAALGPNAGSSAFFWTYQEEPHRSRRKAIIKAHPQVTKLCGPEPLTK
WVVLGVMLTQFTIAYYLTASKTSFFSFKFWALAYVIGATCSQNLFLAIHEMAHGLGFKARIHNQLFAVVSNLPIGIPYAA
GFGPYHLLHHKYLGDSQYDTDLPTVLEALVLNSVAGKAFFATFQIFFYAIRPICVMAIPFSKIHFINLITQFVWDYIVVH
NFGWTPLVYFLLSDFLAGSLHPLAGHFIAEHYVLDPPASEENATSPQDPPQKGTQPEQFSKIAPPETYSYYGPLNIFVYN
AGYHNEHHDFPYVAWTKLPELNRIAKEFYDPLPCHHSWSKVIVDFVFDKRVSLWCRVKRSKEQVDPDDYEHPENSIESTS
TTTGAKIISPAAALAARANVK

GO term prediction

Biological Process

GO:0006629 lipid metabolic process
GO:0030148 sphingolipid biosynthetic process

Molecular Function

GO:0042284 sphingolipid delta-4 desaturase activity

Cellular Component

GO:0016021 integral component of membrane