Protein

MCA_01845_1

Length
396 amino acids

Browser: contigA:5658914-5660105+

RNA-seq: read pairs 2300, FPKM 71.6, percentile rank 73.2% (100% = highest expression)

Protein function

KEGG:K04712DEGS sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5]
EGGNOG:0PFG5FG10374.1dihydroceramide delta(4)-desaturase
CGD closest match:CAL0000198792DES1Sphingolipid delta(4)-desaturase

Protein alignments

%idAln lengthE-value
MIA_00552_168.66%4020.0MIA_00552_1
A0A0J9XIK7_GEOCN67.05%3523e-171Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA21s00571g PE=4 SV=1
A0A1E3PJT9_9ASCO67.05%3462e-167Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46359 PE=4 SV=1
Q6CA36_YARLI62.57%3501e-155YALI0D06237p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D06237g PE=4 SV=1
A0A060SYC7_BLAAD62.09%3643e-152ARAD1A11418p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A11418g PE=4 SV=1
A0A1E4TE26_9ASCO57.14%3573e-146Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1731 PE=4 SV=1
UniRef50_A0A0L1HQ1655.89%3656e-138Dihydroceramide delta-desaturase n=1 Tax=Stemphylium lycopersici TaxID=183478 RepID=A0A0L1HQ16_9PLEO
A0A167E5R9_9ASCO55.99%3591e-141Sphingolipid delta-4 desaturase OS=Sugiyamaella lignohabitans GN=DES1 PE=4 SV=1
DEGS_CANAL53.94%3433e-129Sphingolipid delta(4)-desaturase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=DES1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.5397

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 396

Detailed signature matches

  1. Family IPR011388
    Sphingolipid delta4-desaturase
    1. cd03508 (Delta4-sph...)
    2. PIRSF017228 (Sphngl...)
  2. Domain IPR013866
    Sphingolipid delta4-desaturase, N-terminal
    1. PF08557 (Lipid_DES)
    2. SM01269 (Lipid_DES_2)
  3. Domain IPR005804
    Fatty acid desaturase domain
    1. PF00487 (FA_desaturase)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. NON_CYTOPLASM... (N...)
  3. TMhelix
  4. TRANSMEMBRANE (Tran...)
  5. mobidb-lite (disord...)

Residue annotation

  1. putative di-iron l...

Protein sequence

>MCA_01845_1
MTTDTEIEPPSFRPVEKLPNGKVSHTFNNIDPHSGQDDFYWTYQEEPHRSRRREIIKAHPEVTKLCGPEPLTKYVIMTVM
TIQLTAAYLLRNTPFFSWQVWLTAYIVGATCSQNLFLAIHEMCHGLCFKNRYLNKLFAVFTNLPIGIPYSAGFTPYHLLH
HKYLGDTKYDTDLPTTIEAFVLQTVAGKAFFATFQIFFYAIRPICVMQLPFSDIHFINLVAQFTFDYIVIHFFGWNFFFY
LLLSDFLAGSLHPLAGHFIAEHYVLDPPESTESPSTDPKAEAVAKSPLGNAVISKIAPPETYSYYGPLNIFVYNAGYHNE
HHDFPYVPWTRLPELNRLAKEFYDPLPHHTSWSKVIVDFVFDKRVNLWCRVKRTKEEKDPDDYDHPEVQVEANSAN

GO term prediction

Biological Process

GO:0006629 lipid metabolic process
GO:0030148 sphingolipid biosynthetic process

Molecular Function

GO:0042284 sphingolipid delta-4 desaturase activity

Cellular Component

GO:0016021 integral component of membrane