Protein

MIA_00550_1

Length
1,167 amino acids

Browser: contig01:1584840-1588581-

Protein function

EGGNOG:0PFNTCLA4serine threonine-protein kinase
SGD closest match:S000005242CLA4Serine/threonine-protein kinase CLA4
CGD closest match:CAL0000192143CLA4Serine/threonine-protein kinase CLA4

Protein alignments

%idAln lengthE-value
MCA_01843_182.637%3111.05e-177MCA_01843_1
A0A0J9XDZ3_GEOCN80.062%3211.02e-178Similar to Saccharomyces cerevisiae YHL007C STE20 Cdc42p-activated signal transducing kinase of the PAK (P21-activated kinase) family OS=Geotrichum candidum GN=BN980_GECA11s02155g PE=4 SV=1
UniRef50_A0A0J9XDZ380.062%3212.09e-175Similar to Saccharomyces cerevisiae YHL007C STE20 Cdc42p-activated signal transducing kinase of the PAK (P21-activated kinase) family n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XDZ3_GEOCN
A0A060T7W0_BLAAD81.169%3084.77e-176ARAD1C31130p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C31130g PE=4 SV=1
A0A161HN42_9ASCO75.926%3246.09e-169Serine/threonine protein kinase CLA4 OS=Sugiyamaella lignohabitans GN=CLA4 PE=4 SV=1
F2Z617_YARLI77.170%3111.63e-165YALI0C22770p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C22770g PE=4 SV=1
A0A1E3PMJ3_9ASCO72.561%3289.62e-162Pkinase-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_77924 PE=4 SV=1
A0A1E4T9A5_9ASCO70.068%2941.42e-142Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_58661 PE=4 SV=1
CLA4_CANAL67.085%3191.34e-138Serine/threonine-protein kinase CLA4 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CLA4 PE=1 SV=1
CLA4_YEAST63.323%3198.07e-129Serine/threonine-protein kinase CLA4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CLA4 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0243
Predicted cleavage: 30

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 200 400 600 800 1000 1167

Detailed signature matches

  1. Domain IPR011993
    PH domain-like
    1. G3DSA:2.30.29.30
    2. SSF50729 (PH domain...)
  2. Domain IPR001849
    Pleckstrin homology domain
    1. SM00233 (PH_update)
    2. PS50003 (PH_DOMAIN)
    3. PF00169 (PH)
  3. Domain IPR000095
    CRIB domain
    1. G3DSA:3.90.81...
    2. PF00786 (PBD)
    3. SM00285 (PBD_5)
    4. PS50108 (CRIB)
  4. Domain IPR033923
    p21 activated kinase binding domain
    1. cd01093 (CRIB_PAK_like)
  5. Domain IPR011009
    Protein kinase-like domain
    1. SSF56112 (Protein k...)
  6. Domain IPR000719
    Protein kinase domain
    1. PS50011 (PROTEIN_KI...)
    2. PF00069 (Pkinase)
    3. SM00220 (serkin_6)
  7. SITE IPR017441
    Protein kinase, ATP binding site
    1. PS00107 (PROTEIN_KI...)
  8. SITE IPR008271
    Serine/threonine-protein kinase, active site
    1. PS00108 (PROTEIN_KI...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.10.51...
  3. G3DSA:3.30.20...
  4. NON_CYTOPLASM... (N...)
  5. PIRSF000615 (TyrPK_...)
  6. SIGNAL_PEPTIDE (Sig...)
  7. SIGNAL_PEPTID... (S...)
  8. SIGNAL_PEPTID... (S...)
  9. SIGNAL_PEPTID... (S...)
  10. cd06614 (STKc_PAK)
  11. cd13279 (PH_Cla4_Ste20)
  12. mobidb-lite (disord...)

Residue annotation

  1. GTPase interaction...
  2. ATP binding site c...
  3. active site cd06614
  4. polypeptide substr...
  5. activation loop (A...

Protein sequence

>MIA_00550_1
MSFSSTAAVFSHNAFLNPGPAPAPPNARANPSATSTSGKASNNAQGSAPQSNVHPKQQGATSSTSSTSSTSSASSALSSA
SSSASSMSSFPDSPLSIGNPILMTSTSPYHHLHNKIHTSNDSSVSLSSQQQQQQQQQQYSSLSSPFYTHSPSSSDSSTHS
TTSAISAHSTASMSTSSSNGFNSNSMRIYNASIDSDSTPTASTNNLAYTISPQVTSSSFSTATSSSSPPSKQSKDEPTKG
RFIKQGWTSVKEDGSLRSFMWTKKFLVLRDNTLEFYRNEVSYPSSASPSLSIPLYSVSNVTRVDLKPYCFEIIRSSSNKS
VFVSCKNDPELYSWIDEIYNKCPRSGVSSPTNFTHKVHVGFDPVSRDFTGLPDAWSKLLSASAITKEDFAKNPQAVIEVL
EFYSEQQKEEQNDLLAAEEFRKKAQQAQRAIREAAAGERPTLQATLRKQKSSAQLNAGQGMHPPPPPQPFYKSMAHSNSS
SALNDKFQEWTKTPTSKPSFSHTSSSSSGPQSKTLDHPVISHPKPLHNVATTNNTTTSAAAAATAAIASSSMGINAQATS
SASRINNTSHLAHIAPLRQAPRAPHRPAPPPPSQSPITSNQQQQDLPNMAKLNISAPQHDYHPNNGRSRLDSTSGPSSSA
AAITAAAAASSSSYNKSLNNDRERLERERERVANNSNNALGANIHNGANSSSTSLHKQPLQVYPNAASKPLHHPQPQLAT
AAAKLANLSSTSLTSPSTSSPSEPSALERYGTPVQPLNTKPKALQQHQTVATPPPSNHNSPTSTAPPPPQAPPAIEEPSK
IRKLAASAPSAAPAKQPQQTAQTLTVPGSAGSASSARDAAAAALEGSTPMSSAAKSRLREAEKRISTMTDVQIMEKLRSV
VSSADPETIYQRLKKIGQGASGSVYLAQPIKGSMLSYHRVAIKQIDLLLQPRKELIVNEITVMKESQHPNIVNFLEAYLR
HENELWVVMEYMEGGSLTDIIENNQLNEAQIATICYETCKGLQHLHHKNIIHRDIKSDNMLLDAQGHVKITDFGFCAKLT
EHKNKRATMVGTPYWMAPEVVKQKEYGAKVDVWSLGIMAIEMIESEPPYLNEEPLKALYLIATNGTPQLKHPQQLSREIK
SFLSVCLCVNVTYRASTDELVEHPFLKKGCPREQLASLLTYKNNQRH

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding

Cellular Component

None predicted.