Protein

MCA_01843_1

Length
938 amino acids

Gene name: CLA4

Description: Serine/threonine-protein kinase Cla4; Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family

Browser: contigA:5647379-5650340-

RNA-seq: read pairs 1086, FPKM 14.3, percentile rank 32.9% (100% = highest expression)

Protein function

Annotation:CLA4Serine/threonine-protein kinase Cla4; Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family
KEGG:K19833CLA4 serine/threonine-protein kinase CLA4 [EC:2.7.11.1]
EGGNOG:0PFNTCLA4serine threonine-protein kinase
SGD closest match:S000005242CLA4Serine/threonine-protein kinase CLA4
CGD closest match:CAL0000192143CLA4Serine/threonine-protein kinase CLA4

Protein alignments

%idAln lengthE-value
A0A0J9XDZ3_GEOCN84.42%3080.0Similar to Saccharomyces cerevisiae YHL007C STE20 Cdc42p-activated signal transducing kinase of the PAK (P21-activated kinase) family OS=Geotrichum candidum GN=BN980_GECA11s02155g PE=4 SV=1
UniRef50_A0A0J9XDZ384.42%3080.0Similar to Saccharomyces cerevisiae YHL007C STE20 Cdc42p-activated signal transducing kinase of the PAK (P21-activated kinase) family n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XDZ3_GEOCN
MIA_00550_182.64%3112e-176MIA_00550_1
A0A060T7W0_BLAAD82.47%3082e-178ARAD1C31130p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C31130g PE=4 SV=1
F2Z617_YARLI81.19%3035e-169YALI0C22770p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C22770g PE=4 SV=1
A0A161HN42_9ASCO81.11%3071e-171Serine/threonine protein kinase CLA4 OS=Sugiyamaella lignohabitans GN=CLA4 PE=4 SV=1
A0A1E3PMJ3_9ASCO75.48%3102e-160Pkinase-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_77924 PE=4 SV=1
A0A1E4T9A5_9ASCO70.07%2943e-140Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_58661 PE=4 SV=1
CLA4_CANAL66.45%3079e-135Serine/threonine-protein kinase CLA4 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CLA4 PE=1 SV=1
CLA4_YEAST62.50%3203e-127Serine/threonine-protein kinase CLA4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CLA4 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0558

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 800 938

Detailed signature matches

  1. Domain IPR011993
    PH domain-like
    1. G3DSA:2.30.29.30
    2. SSF50729 (PH domain...)
  2. Domain IPR001849
    Pleckstrin homology domain
    1. SM00233 (PH_update)
    2. PS50003 (PH_DOMAIN)
    3. PF00169 (PH)
  3. Domain IPR000095
    CRIB domain
    1. G3DSA:3.90.81...
    2. PF00786 (PBD)
    3. SM00285 (PBD_5)
    4. PS50108 (CRIB)
  4. Domain IPR033923
    p21 activated kinase binding domain
    1. cd01093 (CRIB_PAK_like)
  5. Domain IPR011598
    Myc-type, basic helix-loop-helix (bHLH) domain
    1. G3DSA:4.10.28...
  6. Domain IPR011009
    Protein kinase-like domain
    1. SSF56112 (Protein k...)
  7. Domain IPR000719
    Protein kinase domain
    1. PS50011 (PROTEIN_KI...)
    2. SM00220 (serkin_6)
    3. PF00069 (Pkinase)
  8. SITE IPR017441
    Protein kinase, ATP binding site
    1. PS00107 (PROTEIN_KI...)
  9. SITE IPR008271
    Serine/threonine-protein kinase, active site
    1. PS00108 (PROTEIN_KI...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.10.51...
  3. G3DSA:3.30.20...
  4. cd06614 (STKc_PAK)
  5. cd13279 (PH_Cla4_Ste20)
  6. mobidb-lite (disord...)

Residue annotation

  1. GTPase interaction...
  2. ATP binding site c...
  3. active site cd06614
  4. polypeptide substr...
  5. activation loop (A...

Protein sequence

>MCA_01843_1
MSFSTTASVFSPNAFLNPGPAPTPPSHSNNNNNNQPNKLYFNDSSGSFSHSPSGSDSSSHLDSNNSSPPSSSANSPTTTN
TTSPQKDDNRGRFIKHGWTSVKEDGSLRSFMWTKKYLVLRDTCLEFYRNEVLSPGLATPSLSIPLYTVSSVTRVDVKPYC
FEIIRSASYKSVFIACKNDAELYSWIDEIYTKCPLTGVSSPTNFTHKVHIGFDPVSGGFTGLPDNWSKLLNASAITKEDY
AKNPQAVIEVLEFYSEQQKEEEEVSYIYDNFKNDSEPNTPSDLSSNNLKSPLERIPSKPQLAPSNSYSNNNNNNNYNINN
NNNNNNNIQRQFNNTANNNNNNFQGMRANNNNNNNYANITPRRQAPRPPQAQQRPPPANVTPIQVPPAQQFRSNIQVASP
LNRHPPPHPHEFNRERLEHEKMRQLNNNTNNINNNNNNNNGRSQDNLRMAPSPQTPLFSPTTGGNNNRPPPQNNMYIPNN
TSVTAGTNTPLQVYPPAFKQNGMNNVYNGNHQNNSAPMLSTMEKYDTPVQPLKPKPKASMNNLKQQQQQQQQQQQQQQQQ
QQQQQQQKAQLDQAPPQSMARPDQGHIAMPTRPKESPSSAPKVGLPATPSTPATPTNQISSSVGQKPVRARQAERRISTM
TDTQIMQKLRSVVDGSDPEANYQKLKKIGQGASGLVFVARPIRGPMTVHKRVAVKQIDLQAQPRKELIVNEITVMKESQH
PNIVNFLEAYLRGRYDLWVVMEYMEGGPLTDIIENNTLTEEQIATICYETCKGLQHLHSKNIIHRDIKSDNMLLDSQGHV
KITDFGFCAKLTETKNKRATMVGTPYWMAPEVVKQKEYGAKVDVWSLGIMAIEMIESEPPYLNEEPIKALYMIATNGTPK
LKHPEQLSKEIKSFLSVCLCVDVKYRASTTELLQHEFLKKGCSLQSLASLLAYKQQHN

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0046983 protein dimerization activity

Cellular Component

None predicted.