MIA_00531_1

Protein

Length

443 amino acids

Browser: contig01:1540710-1542042+

Protein function

EGGNOG:	0PIEF	FG00903.1	cysteine synthase
SGD closest match:	S000003244	YGR012W	Putative cysteine synthase
CGD closest match:	CAL0000195320	orf19.5574	Putative cysteine synthase

Protein alignments

	%id	Aln length	E-value
A0A0J9X3Z3_GEOCN	73.529%	374	0.0	Similar to Saccharomyces cerevisiae YGR012W Putative cysteine synthase OS=Geotrichum candidum GN=BN980_GECA02s02870g PE=4 SV=1
MCA_00438_1	64.578%	415	7.56e-173	MCA_00438_1
A0A161HFX7_9ASCO	64.567%	381	1.83e-158	Putative cysteine synthase OS=Sugiyamaella lignohabitans GN=AWJ20_2137 PE=4 SV=1
A0A060T7X3_BLAAD	66.476%	349	6.36e-156	ARAD1C31504p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C31504g PE=4 SV=1
A0A1E3PL92_9ASCO	59.894%	379	9.97e-149	PALP-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82960 PE=4 SV=1
Q6C6L3_YARLI	60.647%	371	9.69e-144	YALI0E08536p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E08536g PE=4 SV=1
A0A1D8PQ13_CANAL	57.895%	380	1.31e-140	Putative cysteine synthase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.5574 PE=4 SV=1
A0A1E4TE82_9ASCO	62.029%	345	2.69e-140	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1803 PE=4 SV=1
UniRef50_A3LRL7	58.311%	379	2.39e-136	Cysteine synthase (O-acetylserine sulfhydrylase) (O-acetylserine (Thiol)-lyase) (CSase) n=27 Tax=Fungi TaxID=4751 RepID=A3LRL7_PICST
CYSKL_YEAST	61.096%	365	1.39e-139	Putative cysteine synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YGR012W PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0150

Protein family membership

None predicted.

Domains and repeats

Domain
72 - 429
Tryptophan synthase beta subunit-like PLP-dependent enzyme (IPR001926)

1 50 100 150 200 250 300 350 400 443

Detailed signature matches

IPR001926

Tryptophan synthase beta subunit-like PLP-dependent enzyme
1. SSF53686 (Tryptopha...)
  
  72 - 429
  
  SUPERFAMILY
  SSF53686 (Tryptophan synthase beta subunit-like PLP-dependent enzymes)
2. PF00291 (PALP)
  
  86 - 418
  
  Pfam
  PF00291 (PALP)
IPR001216

Cysteine synthase/cystathionine beta-synthase, pyridoxal-phosphate attachment site
1. PS00901 (CYS_SYNTHASE)
  
  111 - 129
  
  PROSITE patterns
  PS00901 (CYS_SYNTHASE)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

35 - 443

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:3.40.50...

244 - 432

GENE3D
G3DSA:3.40.50.1100 (G3DSA:3.40.50.1100)

116 - 243

GENE3D
G3DSA:3.40.50.1100 (G3DSA:3.40.50.1100)
NON_CYTOPLASM... (N...)

1 - 11

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TMhelix

15 - 34

TMHMM
TMhelix (TMhelix)
TRANSMEMBRANE (Tran...)

12 - 34

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
cd01561 (CBS_like)

90 - 425

CDD
cd01561 (CBS_like)
mobidb-lite (disord...)

41 - 61

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

dimer interface cd...

94M

dimer interface
94M, 95V, 96E, 109L, 115A, 117P, 161M, 164R, 180T, 181E, 184Q, 185L, 188T, 189L, 263S, 264Q, 381V, 382S, 383H, 385G, 386I, 387F, 411T, 421S, 424L
CDD
cd01561 (CBS_like)

95V

dimer interface
94M, 95V, 96E, 109L, 115A, 117P, 161M, 164R, 180T, 181E, 184Q, 185L, 188T, 189L, 263S, 264Q, 381V, 382S, 383H, 385G, 386I, 387F, 411T, 421S, 424L
CDD
cd01561 (CBS_like)

96E

dimer interface
94M, 95V, 96E, 109L, 115A, 117P, 161M, 164R, 180T, 181E, 184Q, 185L, 188T, 189L, 263S, 264Q, 381V, 382S, 383H, 385G, 386I, 387F, 411T, 421S, 424L
CDD
cd01561 (CBS_like)

109L

dimer interface
94M, 95V, 96E, 109L, 115A, 117P, 161M, 164R, 180T, 181E, 184Q, 185L, 188T, 189L, 263S, 264Q, 381V, 382S, 383H, 385G, 386I, 387F, 411T, 421S, 424L
CDD
cd01561 (CBS_like)

115A

dimer interface
94M, 95V, 96E, 109L, 115A, 117P, 161M, 164R, 180T, 181E, 184Q, 185L, 188T, 189L, 263S, 264Q, 381V, 382S, 383H, 385G, 386I, 387F, 411T, 421S, 424L
CDD
cd01561 (CBS_like)

117P

dimer interface
94M, 95V, 96E, 109L, 115A, 117P, 161M, 164R, 180T, 181E, 184Q, 185L, 188T, 189L, 263S, 264Q, 381V, 382S, 383H, 385G, 386I, 387F, 411T, 421S, 424L
CDD
cd01561 (CBS_like)

161M

dimer interface
94M, 95V, 96E, 109L, 115A, 117P, 161M, 164R, 180T, 181E, 184Q, 185L, 188T, 189L, 263S, 264Q, 381V, 382S, 383H, 385G, 386I, 387F, 411T, 421S, 424L
CDD
cd01561 (CBS_like)

164R

dimer interface
94M, 95V, 96E, 109L, 115A, 117P, 161M, 164R, 180T, 181E, 184Q, 185L, 188T, 189L, 263S, 264Q, 381V, 382S, 383H, 385G, 386I, 387F, 411T, 421S, 424L
CDD
cd01561 (CBS_like)

180T

dimer interface
94M, 95V, 96E, 109L, 115A, 117P, 161M, 164R, 180T, 181E, 184Q, 185L, 188T, 189L, 263S, 264Q, 381V, 382S, 383H, 385G, 386I, 387F, 411T, 421S, 424L
CDD
cd01561 (CBS_like)

181E

dimer interface
94M, 95V, 96E, 109L, 115A, 117P, 161M, 164R, 180T, 181E, 184Q, 185L, 188T, 189L, 263S, 264Q, 381V, 382S, 383H, 385G, 386I, 387F, 411T, 421S, 424L
CDD
cd01561 (CBS_like)

184Q

dimer interface
94M, 95V, 96E, 109L, 115A, 117P, 161M, 164R, 180T, 181E, 184Q, 185L, 188T, 189L, 263S, 264Q, 381V, 382S, 383H, 385G, 386I, 387F, 411T, 421S, 424L
CDD
cd01561 (CBS_like)

185L

dimer interface
94M, 95V, 96E, 109L, 115A, 117P, 161M, 164R, 180T, 181E, 184Q, 185L, 188T, 189L, 263S, 264Q, 381V, 382S, 383H, 385G, 386I, 387F, 411T, 421S, 424L
CDD
cd01561 (CBS_like)

188T

dimer interface
94M, 95V, 96E, 109L, 115A, 117P, 161M, 164R, 180T, 181E, 184Q, 185L, 188T, 189L, 263S, 264Q, 381V, 382S, 383H, 385G, 386I, 387F, 411T, 421S, 424L
CDD
cd01561 (CBS_like)

189L

dimer interface
94M, 95V, 96E, 109L, 115A, 117P, 161M, 164R, 180T, 181E, 184Q, 185L, 188T, 189L, 263S, 264Q, 381V, 382S, 383H, 385G, 386I, 387F, 411T, 421S, 424L
CDD
cd01561 (CBS_like)

263S

dimer interface
94M, 95V, 96E, 109L, 115A, 117P, 161M, 164R, 180T, 181E, 184Q, 185L, 188T, 189L, 263S, 264Q, 381V, 382S, 383H, 385G, 386I, 387F, 411T, 421S, 424L
CDD
cd01561 (CBS_like)

264Q

dimer interface
94M, 95V, 96E, 109L, 115A, 117P, 161M, 164R, 180T, 181E, 184Q, 185L, 188T, 189L, 263S, 264Q, 381V, 382S, 383H, 385G, 386I, 387F, 411T, 421S, 424L
CDD
cd01561 (CBS_like)

381V

dimer interface
94M, 95V, 96E, 109L, 115A, 117P, 161M, 164R, 180T, 181E, 184Q, 185L, 188T, 189L, 263S, 264Q, 381V, 382S, 383H, 385G, 386I, 387F, 411T, 421S, 424L
CDD
cd01561 (CBS_like)

382S

dimer interface
94M, 95V, 96E, 109L, 115A, 117P, 161M, 164R, 180T, 181E, 184Q, 185L, 188T, 189L, 263S, 264Q, 381V, 382S, 383H, 385G, 386I, 387F, 411T, 421S, 424L
CDD
cd01561 (CBS_like)

383H

dimer interface
94M, 95V, 96E, 109L, 115A, 117P, 161M, 164R, 180T, 181E, 184Q, 185L, 188T, 189L, 263S, 264Q, 381V, 382S, 383H, 385G, 386I, 387F, 411T, 421S, 424L
CDD
cd01561 (CBS_like)

385G

dimer interface
94M, 95V, 96E, 109L, 115A, 117P, 161M, 164R, 180T, 181E, 184Q, 185L, 188T, 189L, 263S, 264Q, 381V, 382S, 383H, 385G, 386I, 387F, 411T, 421S, 424L
CDD
cd01561 (CBS_like)

386I

dimer interface
94M, 95V, 96E, 109L, 115A, 117P, 161M, 164R, 180T, 181E, 184Q, 185L, 188T, 189L, 263S, 264Q, 381V, 382S, 383H, 385G, 386I, 387F, 411T, 421S, 424L
CDD
cd01561 (CBS_like)

387F

dimer interface
94M, 95V, 96E, 109L, 115A, 117P, 161M, 164R, 180T, 181E, 184Q, 185L, 188T, 189L, 263S, 264Q, 381V, 382S, 383H, 385G, 386I, 387F, 411T, 421S, 424L
CDD
cd01561 (CBS_like)

411T

dimer interface
94M, 95V, 96E, 109L, 115A, 117P, 161M, 164R, 180T, 181E, 184Q, 185L, 188T, 189L, 263S, 264Q, 381V, 382S, 383H, 385G, 386I, 387F, 411T, 421S, 424L
CDD
cd01561 (CBS_like)

421S

dimer interface
94M, 95V, 96E, 109L, 115A, 117P, 161M, 164R, 180T, 181E, 184Q, 185L, 188T, 189L, 263S, 264Q, 381V, 382S, 383H, 385G, 386I, 387F, 411T, 421S, 424L
CDD
cd01561 (CBS_like)

424L

dimer interface
94M, 95V, 96E, 109L, 115A, 117P, 161M, 164R, 180T, 181E, 184Q, 185L, 188T, 189L, 263S, 264Q, 381V, 382S, 383H, 385G, 386I, 387F, 411T, 421S, 424L
CDD
cd01561 (CBS_like)
catalytic residue ...

122K

catalytic residue
122K
CDD
cd01561 (CBS_like)
pyridoxal 5'-phosp...

122K

pyridoxal 5'-phosphate binding site
122K, 154S, 277A, 278G, 279T, 280G, 281G, 282T, 345G, 391S, 417C, 418D
CDD
cd01561 (CBS_like)

154S

pyridoxal 5'-phosphate binding site
122K, 154S, 277A, 278G, 279T, 280G, 281G, 282T, 345G, 391S, 417C, 418D
CDD
cd01561 (CBS_like)

277A

pyridoxal 5'-phosphate binding site
122K, 154S, 277A, 278G, 279T, 280G, 281G, 282T, 345G, 391S, 417C, 418D
CDD
cd01561 (CBS_like)

278G

pyridoxal 5'-phosphate binding site
122K, 154S, 277A, 278G, 279T, 280G, 281G, 282T, 345G, 391S, 417C, 418D
CDD
cd01561 (CBS_like)

279T

pyridoxal 5'-phosphate binding site
122K, 154S, 277A, 278G, 279T, 280G, 281G, 282T, 345G, 391S, 417C, 418D
CDD
cd01561 (CBS_like)

280G

pyridoxal 5'-phosphate binding site
122K, 154S, 277A, 278G, 279T, 280G, 281G, 282T, 345G, 391S, 417C, 418D
CDD
cd01561 (CBS_like)

281G

pyridoxal 5'-phosphate binding site
122K, 154S, 277A, 278G, 279T, 280G, 281G, 282T, 345G, 391S, 417C, 418D
CDD
cd01561 (CBS_like)

282T

pyridoxal 5'-phosphate binding site
122K, 154S, 277A, 278G, 279T, 280G, 281G, 282T, 345G, 391S, 417C, 418D
CDD
cd01561 (CBS_like)

345G

pyridoxal 5'-phosphate binding site
122K, 154S, 277A, 278G, 279T, 280G, 281G, 282T, 345G, 391S, 417C, 418D
CDD
cd01561 (CBS_like)

391S

pyridoxal 5'-phosphate binding site
122K, 154S, 277A, 278G, 279T, 280G, 281G, 282T, 345G, 391S, 417C, 418D
CDD
cd01561 (CBS_like)

417C

pyridoxal 5'-phosphate binding site
122K, 154S, 277A, 278G, 279T, 280G, 281G, 282T, 345G, 391S, 417C, 418D
CDD
cd01561 (CBS_like)

418D

pyridoxal 5'-phosphate binding site
122K, 154S, 277A, 278G, 279T, 280G, 281G, 282T, 345G, 391S, 417C, 418D
CDD
cd01561 (CBS_like)

Protein sequence

>MIA_00531_1
MPAFLSLHSDAVPTALLLAISSALLGAYSAYLVIDARDSHRHSQSSTTNSPPSSPSSHSIELTDLTSSKLPTIPLAPLQP
VRAGVEELIGNTPMVELRSLSAATGCRILAKLELANPGGSAKDRVALAIIEAAEAAGQISPHSGDAVFEGTSGSTGISLA
MLARAKGYTAHIALPDDTSTEKVQLLETLGAVVYKVRPASIVDSNQYVNFARRKTNKINAAADAAAAENPTGPRLPRAVF
ADQFENEANWRTHYKHTGPEIFSQTDGGKLDAFITSAGTGGTISGVARFLKSNIKRSPGSAPFRVILADPQGSGFYNRIK
YGVMYAPTEQEGTRRRHQVDTIVEGVGLNRITANFQAGEQYIDDAVRVSDKEALQMAKWLVSHDGIFVGSSSAINCVATY
RTAKALGPGHTIVTILCDSGSRHLSKFWKEAQSVESLETLDNL

GO term prediction

Biological Process

GO:0006535 cysteine biosynthetic process from serine

Molecular Function

None predicted.

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

MIA_00531_1

Protein function

Protein alignments

Mitochondrial localization by mitoprotII

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

Protein sequence

GO term prediction

Biological Process

Molecular Function

Cellular Component