Protein
MIA_00505_1
Length
400 amino acids
Browser: contig01:1453284-1454549+
Protein function
| EGGNOG: | 0PKRD | PPM1 | Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues |
|---|---|---|---|
| SGD closest match: | S000002843 | PPM1 | Leucine carboxyl methyltransferase 1 |
| CGD closest match: | CAL0000196930 | PPM1 | Leucine carboxyl methyltransferase 1 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MCA_00157_1 | 60.784% | 357 | 4.64e-158 | MCA_00157_1 |
| A0A0J9XAX2_GEOCN | 52.547% | 373 | 1.61e-119 | Similar to Saccharomyces cerevisiae YDR435C PPM1 Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p) OS=Geotrichum candidum GN=BN980_GECA07s03002g PE=4 SV=1 |
| UniRef50_A0A0J9XAX2 | 52.547% | 373 | 3.30e-116 | Similar to Saccharomyces cerevisiae YDR435C PPM1 Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p) n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XAX2_GEOCN |
| A0A060SYK3_BLAAD | 44.068% | 354 | 6.02e-98 | ARAD1A12980p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A12980g PE=4 SV=1 |
| LCMT1_YARLI | 44.083% | 338 | 8.09e-85 | Leucine carboxyl methyltransferase 1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=PPM1 PE=3 SV=1 |
| A0A1E3PKK5_9ASCO | 40.822% | 365 | 1.52e-80 | Leucine carboxyl methyltransferase (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_11095 PE=4 SV=1 |
| A0A167CFC1_9ASCO | 45.583% | 283 | 5.06e-75 | Ppm1p OS=Sugiyamaella lignohabitans GN=PPM1 PE=4 SV=1 |
| LCMT1_CANAL | 35.955% | 356 | 9.71e-65 | Leucine carboxyl methyltransferase 1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PPM1 PE=3 SV=1 |
| A0A1E4TF98_9ASCO | 35.593% | 354 | 1.38e-60 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_105161 PE=4 SV=1 |
| LCMT1_YEAST | 31.143% | 350 | 3.31e-42 | Leucine carboxyl methyltransferase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PPM1 PE=1 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.3458
Predicted cleavage: 45
Protein family membership
- Methyltransferase Ppm1/Ppm2/Tcmp (IPR007213)
- Leucine carboxyl methyltransferase 1, LCMT1 (IPR016651)
Domains and repeats
-
Domain
1
50
100
150
200
250
300
350
400
400
Detailed signature matches
-
-
PF04072 (LCM)
-
-
-
PIRSF016305 (LCMT)
-
-
-
SSF53335 (S-adenosy...)
-
no IPR
Unintegrated signatures
-
-
mobidb-lite (disord...)
Protein sequence
>MIA_00505_1 MAGRQNPAQGFQLNDSLPHSQHKPHTSFGASANRVTPGLLAGRRGPFVSRQDRIIQSTDIDALSSKYSAFLKGYIQDPYL EAIVNGQKNFSRPRDNVTSSFITKFPIINIGSYIRNYALNLIVDQMIAAVLPTNSKCQIISLGAGSDTRAFNLFAQNGTD KIVYHEIDFSVTTAKKVATIMATPELQKIVWPSLPHNELPTLSSSGTEPNDEIHTPHYHLHAKDLREIISSSDLLQGMDP TFPTLVLSECCLCYLQPDKTDHVLEWLSSHFTSGLGIAVYEPIGGNDSFGKVMIENLASRGISLPTLKKFPTLESQVQRL VDHKFAVNGGLAAANDIWSIYEDWIPETEKTRISKLEVLDELEELRILFQHYCISWAVTDGSSDSPWVMNFSKFAYKTRN
GO term prediction
Biological Process
GO:0032259 methylation
Molecular Function
GO:0008168 methyltransferase activity
Cellular Component
None predicted.